Publications by authors named "Reger R Mikaeel"
Background: The incidence rate of colorectal cancer (CRC) in young adults is rising in parallel with type 2 diabetes (T2D). The majority of CRC develop through two main subtypes of precursor lesions; adenomas and serrated lesions. The associations between age and T2D on development of precursor lesions remain uncertain.
View Article and Find Full Text PDFSurvey of germline variants in cancer-associated genes in young adults with colorectal cancer.
Genes Chromosomes Cancer
February 2022
Colorectal cancer (CRC) incidence in young adults is rising. Identifying genetic risk factors is fundamental for the clinical management of patients and their families. This study aimed to identify clinically significant germline variants among young adults with CRC.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of the RNF43 gene in causing an inherited risk for colorectal cancer (CRC), revealing that two family members with CRC share a likely-pathogenic variant.
- Both individuals were diagnosed with CRC at ages 50 and 65, and both tumors had specific genetic characteristics, including mutations in BRAF.
- The identified RNF43 variant leads to an altered RNA and a nonfunctional protein, reinforcing the idea that RNF43 acts as a tumor suppressor in CRC development and should be considered in hereditary cancer predisposition studies.
Immunohistochemistry features and molecular pathology of appendiceal neoplasms.
Crit Rev Clin Lab Sci
September 2021
Primary appendiceal neoplasms (ANs) comprise a heterogeneous group of tumors. The pathology and classification of ANs have been controversial, and thus, a new classification of these neoplasms was published in the World Health Organization (WHO) classification of tumors (5th edition, 2019). However, immunohistochemistry (IHC) features of epithelial ANs are not explained in this edition and the limited data on the molecular pathology of these tumors shows inconsistent findings in various studies.
View Article and Find Full Text PDFAppendiceal neoplasm incidence and mortality rates are on the rise in Australia.
Expert Rev Gastroenterol Hepatol
February 2021
Objectives: The study aimed to examine the incidence and mortality rates of appendiceal neoplasms (ANs) in Australia.
Methods: A retrospective analysis was performed on national data obtained from the Australian Institute of Health and Welfare (AIHW) from 1982 to 2013. Changes to the incidence, and the cancer-specific mortality following the diagnosis of ANs were analyzed over this time period, with stratification performed for histological subtype, gender, and age groups (<50y and ≥50y).
Young-onset colorectal cancer is associated with a personal history of type 2 diabetes.
Asia Pac J Clin Oncol
February 2021
Background: Colorectal cancer (CRC) is rising in incidence in young adults, and this observation is currently unexplained. We investigated whether having a personal history of type 2 diabetes mellitus (T2D) was a potential risk factor for young-onset colorectal cancer (YOCRC).
Methods: The South Australian Young Onset (SAYO) CRC study is a series of young adults with CRC below age 55.