Persistent cortical excitatory neuron dysregulation in adult haploinsufficient mice.

mutations cause autism spectrum disorder, cognitive deficits, and macrocephaly. mouse models exhibit macrocephaly and transcriptional pathology, with inconsistent findings regarding neurogenesis, neuron function, and behavior. Via stereology and single nucleus transcriptomics (snRNA-seq), we found increased cortical volume was not explained by increase in neuron number.

A prospective study to determine the safety and feasibility of opioid-free discharge after percutaneous nephrolithotomy.

Background: The American opioid epidemic continues and further efforts are needed to reduce unnecessary opioid prescriptions after urologic surgery. This is a pragmatic feasibility study to evaluate the safety and feasibility of opioid-free discharge after percutaneous nephrolithotomy (PCNL) utilizing a nonopioid protocol consisting of preoperative counseling, multimodal analgesics, and detailed postoperative instructions.

Methods: A prospective feasibility study (Clinicaltrials.

Persistent cortical excitatory neuron dysregulation in adult haploinsufficient mice.

mutations cause autism spectrum disorder, cognitive deficits, and macrocephaly. mouse models exhibit macrocephaly and transcriptional pathology, with inconsistent findings regarding neurogenesis, neuron function, and behavior. Via stereology and single nucleus transcriptomics (snRNA-seq), we found increased cortical volume was not explained by increase in neuron number.

Effectiveness of a Regionalized Care Model in Treating Fournier's Gangrene.

ObjectivesTo evaluate the impact of transferring patients with Fournier's gangrene (FG) to a tertiary referral hospital (TRH) on survival and outcomes.MethodsWe conducted a retrospective analysis of FG cases treated at our TRH from January 2015 to January 2022. Clinicodemographic, laboratory, perioperative, and mortality data were collected.

Assessment of mechanical bowel preparation prior to nephrectomy in the minimally invasive surgery era: insights from a national database analysis in the United States.

Purpose: This study was performed to evaluate the association between mechanical bowel preparation (MBP) and perioperative outcomes following nephrectomy in the minimally invasive surgery (MIS) era.

Methods: All partial and radical nephrectomies between 2019 and 2021 from the National Surgical Quality Improvement Program database were evaluated. Thirty-day perioperative outcomes were compared between groups where MBP was performed vs.

Timing Considerations for Artificial Urinary Sphincter Implantation Postpelvic Radiotherapy.

Objective: To explore the optimal timing for placing an artificial urinary sphincter (AUS) postradiation therapy (RT).

Methods: A bi-institutional retrospective review of all patients who underwent their first (virgin) AUS placement after pelvic RT between January 1, 2011 and July 1, 2023. To determine the optimal timeline for device implantation 2-5years post-RT, we compared hazard ratios for device revision/explantation (Rev/Exp) using Kaplan-Meier curves for each year (earlier vs later than 2/3/4/5 years post-RT).

Comparing the lifespan of virgin artificial urinary sphincters in radiated patients: transcorporal vs. standard placement.

Purpose: To compare the lifespan of first transcorporal cuff (TC) placement of an artificial urinary sphincter (AUS) versus standard placement (SP) in patients with prior radiotherapy (RT) for prostate cancer (PCa).

Methods: We reviewed first (virgin) AUS placements from two high-volume care centers between 1/2011 and 1/2021, including PCa patients with RT history. AUS lifespan was assessed via the hazard ratio of device explantation and/or revision within a ten-year timeframe for the TC vs.

Consistent predictive ability of prostate-specific antigen density prediction model for clinically significant prostate cancer across age strata.

Background: Prebiopsy prostate-specific antigen density (PSAD) is a well-known predictor of clinically significant prostate cancer (csPCa). Since prostate-specific antigen (PSA) and prostate volume (PV) increase normally with aging, PSAD thresholds may vary. The purpose of the study was to determine if PSAD was predictive of csPCa in different age strata.

Less qualitative multiparametric magnetic resonance imaging in prostate cancer can underestimate extraprostatic extension in higher grade tumors.

Background: Multiparametric magnetic resonance imaging (mpMRI) is increasingly used for risk stratification and preoperative staging of prostate cancer. It remains unclear how Grade Group (GG) interacts with the ability of mpMRI to determine the presence of extraprostatic extension (EPE) on surgical pathology.

Methods: A retrospective review of a robotic assisted laparoscopic radical prostatectomy (RALP) database from 2016-2020 was performed.

Recommending HPV vaccination at age 9 to reduce health disparities: Communication challenges and opportunities.

The HPV vaccine is approved for children as young as age nine and recommended by the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices routinely for ages 11-12. However, many U.S.

Direct Oral Anticoagulants for Venous Thromboembolism Prophylaxis Following Robot-assisted Radical Cystectomy: A Retrospective Feasibility Study at a Single Academic Medical Center.

Objectives: To evaluate the use of direct oral anticoagulants following radical cystectomy for venous thromboembolism prophylaxis. We compared the experience of those who received venous thromboembolism prophylaxis following a robot-assisted radical cystectomy with either a direct oral anticoagulant or enoxaparin.

Methods: Medical records of 66 patients who underwent robot-assisted radical cystectomy between July 2017 and May 2020 at a single academic institution were reviewed retrospectively.

A Social Identity Threat Perspective on Why Partisans May Engage in Greater Victim Blaming and Sexual Assault Myth Acceptance in the #MeToo Era.

This study examined how U.S. partisans ( = 1,154) may engage in greater victim blaming and sexual assault myth acceptance to defend their political identities in the #MeToo era.

The evolving landscape of menstrual product advertisements in the United States: 2008-2018.

As menstrual product advertising evolves within the United States, it is important to understand how advertising messages, which have been shown to impact self-esteem and feelings of shame, may be influencing young people today. We analyzed menstrual product advertising over ten years (2008-2018) through a survey ( = 198) and focus groups ( = 21) with college and graduate student-aged adults. Three themes emerged: an emphasis on femininity and shame; the presence and role of men in the menstrual process; and racial, gender and body type inclusivity.

Explicit, Voluntary, and Conscious: Assessment of the Importance of Adopting an Affirmative Consent Definition for Sexual Assault Prevention Programming on College Campuses.

Sexual assault is a major concern on college campuses. Some colleges and universities adopt and educate their students using an affirmative consent standard, such that for a sexual encounter to be considered consensual (and thus not an act of sexual assault), it must include explicit, voluntary, and conscious agreement to engage in sexual activity by all parties involved. The current study sought to examine the extent to which accurate knowledge and understanding of affirmative sexual consent may explain college students' intentions to engage in affirmative sexual consent communication, alongside other influential predictors, as proposed by the Integrated Behavioral Model.

A systematic literature review to examine the potential for social media to impact HPV vaccine uptake and awareness, knowledge, and attitudes about HPV and HPV vaccination.

This article summarizes the findings from a systematic literature review to examine how social media may impact HPV vaccine uptake and HPV and HPV vaccine related awareness, knowledge, and attitudes. Study inclusion criteria was original data collection of at least one data point about social media and HPV and/or HPV vaccination, such that the study provided insight into how social media content may influence HPV and HPV vaccine related knowledge, attitudes, and/or behaviors. A total of 44 relevant articles were identified using the following databases: PubMed, PsycINFO, Communication Source, Sociological Abstracts, Business Source Elite, and the Educational Resources Information Center (ERIC).

Development and Evaluation of a Social Media Health Intervention to Improve Adolescents' Knowledge About and Vaccination Against the Human Papillomavirus.

This study describes the formative research, execution, and evaluation of a social media health intervention to improve adolescents' knowledge about and vaccination against human papillomavirus (HPV). Based on the results from formative focus groups with adolescents (N = 38) to determine intervention feasibility, parameters, and message preferences, we developed and conducted a pretest/posttest evaluation of a 3-month social media health intervention for adolescents who had not completed the HPV vaccine series (N = 108). Results revealed that adolescents who fully engaged with the intervention improved in their knowledge compared with a control group, and many were also likely to have interpersonal discussions with others about what they learned.