Optimized formulation of a three-component extract mixture from Moroccan Crocus sativus L. (Stigmas, leaves, and Tepals) for enhanced antioxidant activity.

This study evaluated the antioxidant potential of a three-component mixture derived from Crocus sativus L. stigmas, leaves, and tepals, aiming to valorize these underutilized by-products. Hydroethanolic extracts were chemically profiled using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD), identifying major bioactive compounds including crocin (11.

Phytochemical Profile, Genotoxicity, and In Silico Toxicity Assessment, Antioxidant, and Neuroprotective Effects of Clinopodium nepeta Essential Oil: Inhibition of Acetylcholinesterase, Butyrylcholinesterase, and Monoamine Oxidase.

The aim of this study was to evaluate the chemical composition, genotoxicity, in silico predicted toxicity, antioxidant activity, and neuroprotective potential of essential oil (EO) extracted from the aromatic and medicinal plant Clinopodium nepeta, native to eastern Morocco. Chemical composition was assessed by gas chromatography-mass spectrometry, revealing the presence of 19 compounds, the main ones being neoisomenthol (29.66%), dihydrocarvone (11.

Phytochemical Profiling, Antioxidant Capacity, and the Antidiabetic Potential of Extracts: UHPLC-MS/MS Analysis, In Vitro Enzyme Inhibition Assays, and Molecular Docking Studies.

(L.) is known to be characterized by numerous pharmacological prospects comprising antioxidant, anticancer, antibacterial, and antidiabetic properties. The core objective of the present study is to harness the chemical composition of aqueous extract (EA), hydroethanolic extract (EHA), and ethanolic extract (EE), followed by the investigation of the antidiabetic potential of extracts on two important targets, porcine proteins (α-amylase and hemoglobin).

The Polysulfide Containing Medicinal Plant Parkia speciosa Hassk. has Both Antioxidant and Cardioprotective Activity.

The aim was to investigate any cardioprotective potential of hydrogen sulfide (HS) released by oil extracted from Parkia speciosa Hassk. seeds (PsH). To achieve this, an in vivo heart failure model in Wistar rats was induced by daily administration of isoproterenol (ISO, 5 mg/kg) for a week.

Evaluation of the Dermatoprotective Properties of Clinopodium nepeta and Thymus vulgaris Essential Oils: Phytochemical Analysis, Anti-Elastase, Anti-Tyrosinase, Photoprotective Activities, and Antimicrobial Potential Against Dermatopathogenic Strains.

Background: The growing demand on natural ingredients in cosmetics has immensely contributed to a renewed interest in cosmetic industry in plant derivatives, especially essential oils. The aim of this study is to examine the dermatoprotective and antifungal properties of Clinopodium nepeta (CNEO) and Thymus vulgaris (TVEO) essential oils.

Materials And Methods: Gas chromatography-mass spectrometry (GC-MS) analysis was performed to identify the chemical composition of the essential oils.

Investigation into the role of layered nanoporous modified clays for adsorption/desorption of rosemary essential oil in the gas phase and the ability of this system as an antioxidant and preservation agent in food applications.

A new green composite material with antioxidant properties and specific-targeting capabilities was developed using Montmorillonite Clay in modified forms for rosemary essential oil gaseous adsorption without harmful chemicals or excessive heat. The modified clays were tested for their adsorption capabilities, with the sodic clay showing the highest affinity for the essential oil. The study also found that the adsorbed essential oil on sodic clay had the highest antioxidant activity compared to the organic and pillared clays.

Nutritional value antioxidant strength and antimicrobial efficacy of fig pastes from eastern morocco.

Figs are delectable, beneficial, nutritious, and seasonal; nevertheless, they deteriorate quickly, making processing the optimal method for preservation. Drying figs is the most practical and efficient way to preserve them. Paste is another possibility.

Elicitor-driven enhancement of phenolic compounds in geranium callus cultures: phytochemical profiling via LC-MS/MS and biological activities.

This research explores the effects of chitosan (CHT) and salicylic acid (SA) as elicitors on the production of phenolic and flavonoid compounds in Hort. Callus cultures on solid media, aiming to enhance antioxidant, anti-tyrosinase, and anti-elastase properties. Calli were treated with various concentrations of CHT (25, 50, 75, and 100 mg/mL) and SA (25, 50, 75, and 100 µM), and their phytochemical profiles were examined through LC-MS/MS analysis.

A Traditional Gum Exudate From Ameliorates Etha-Nol-Mediated Gastric Ulcer in Rats: Possible Molecular Mechanisms.

(Bene) is a native Mediterranean plant that exudates a resinous therapeutic oleoresin gum used for many inflammatory-related diseases. Therefore, the present study evaluates the acute toxicity and the gastroprotective effects of gum (PAG) on ethanol-mediated gastric ulcers in rats. Sprague Dawley rats (30) were placed in 5 cages: Group A received 10% tween 20; Group B, ulcer control, received 10% tween 20; reference rats (C, received 20 mg/kg omeprazole), groups D and E received 250 and 500 mg/kg of PAG, respectively.

The Gastroprotective Effects of Salvia indica L. and Selenium In Vivo Study.

Salvia indica L. is a traditional therapeutic herb used for numerous health purposes, including intestinal and stomach disorders. The current investigation includes the phytochemical profiling, acute toxicity, and gastroprotective roles of Salvia indica leave extracts (SILE) in combination with selenium (known to facilitate mucosal regeneration, reduce lipid peroxidation, and increase antioxidant activity) in the gastric ulcer animal model.

Prophylactic Effects of Rhamnetin Flavonoid on Indomethacin-Induced Gastric Ulceration by Modulating HSP 70/Bax, SOD/MDA and TNF-α/IL-10.

Rhamnetin is a naturally occurring flavonoid compound found in many wild plant species and indigenous fruits. Despite its numerous biological potentials, such as anti-inflammatory, antioxidant and antimicrobial effects, there is a lack of literature elucidating its gastroprotective action and anticipating molecular mechanism. Natural products can be a good alternative to overcome the side effects and relapses associated with anti-ulcer drugs.

Optimization of the Antibacterial Activity of a Three-Component Essential Oil Mixture from Moroccan , , and Using a Simplex-Centroid Design.

Background/objectives: The rise of antibiotic-resistant pathogens has become a global health crisis, necessitating the development of alternative antimicrobial strategies. This study aimed to optimize the antibacterial effects of essential oils (EOs) from , , and , enhancing their efficacy through optimized mixtures.

Methods: This study utilized a simplex-centroid design to optimize the mixture ratios of EOs for maximal antibacterial and antioxidant effectiveness.

Multi-Element Exposure and Health Risks of Grains from Ambagarh Chowki, Chhattisgarh, India.

Rice, wheat, and maize grains are staple foods, widely consumed for their mineral and nutritional values. However, they can accumulate toxic elements from contaminated soils, posing health risks. This study investigates the bioaccumulation patterns of 52 elements (including nutrients, heavy metals, and rare earth elements) in various parts (grain, husk, straw, and root) of cereals grown in a heavily polluted region.

Persimmon (Diospyros kaki L.) leaves accelerates skin tissue regeneration in excisional wound model: possible molecular mechanisms.

Persimmon (Diospyros kaki L.) leaves are a traditional medicinal herb used for treating many infectious and inflammatory-related conditions, including wound healing. To validate its traditional use, our study evaluates the acute toxicity and wound-healing effects of methanolic extracts of Persimmon (Diospyros kaki L.

Evaluation of the Interaction Between Menthol and Camphor, Major Compounds of Clinopodium nepeta Essential Oil: Antioxidant, Anti-inflammatory and Anticancer Activities Against Breast Cancer Cell Lines.

This study evaluates the antioxidant, anti-inflammatory, and anticancer activities of camphor, menthol, and their equimolar combination. In silico toxicity analysis confirmed the absence of toxic effects for both compounds. Antioxidant activity, assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, revealed a synergistic effect of the equimolar combination with half-maximal inhibitory concentration (IC) values of 10.

Nutritional value, HPLC-DAD analysis and biological activities of Ceratonia siliqua L. pulp based on in vitro and in silico studies.

The phytochemical, nutritional, and biological features of wild carob pulp from Tanzight (TN), Ait-Waada (AW), and Tizi-ghnayn (TG) in Azilal were studied. The results of the study reveal that the carob pulp examined has a low-fat level. AW had the most total sugar (78.

Phytochemical Profiling, Acute Toxicity, and Hepatoprotective Effects of in Thioacetamide-Induced Liver Cirrhosis in Rats.

Evaluation of of the family Boraginaceae during previous investigations determined numerous therapeutic potentials against inflammatory-related diseases. The present study evaluates the phytochemical, acute toxicity, and hepatoprotective effects of methanolic extracts of (MEAL) against thioacetamide (TAA)-induced liver injury in rats. The phytochemical profiling of MEAL followed a Folin-Ciocalteu and 10% AlCl3 procedure using a spectrophotometer.

Corrigendum: Ethnobotanical survey and scientific validation of liver-healing plants in northeastern Morocco.

[This corrects the article DOI: 10.3389/fphar.2024.

Authentication of Honey from the Middle Atlas Mountains of Morocco: Physicochemical Properties, Mineral Content, Sugar, Polyphenol Profiles, and Antioxidant Capacity.

The jujube honey from the Moroccan Middle Atlas area is thoroughly described in this study, which takes into account melissopalynological, physicochemical, antioxidant, mineral, and phytochemical characteristics. Twelve samples of jujube honey underwent in-depth analyses between 2019 and 2021. The honey's unifloral origin was confirmed by pollen analysis, which revealed that pollen predominated along with pollen from 21 other species.

Antidiabetic potential of aqueous extract: insights into pancreatic lipase inhibition, antioxidant activity, antiglycation at multiple stages and anti-inflammatory effects.

Background: With the increasing global prevalence of type 2 diabetes (T2D) and obesity, there is a pressing need for novel therapeutic interventions. a medicinal plant traditionally used for various ailments, holds promise as a potential agent for T2D management, particularly in Morocco, where it is commonly used to treat diabetes. This study aims to evaluate the pharmacological potential of aqueous extract (AqLs) by assessing its lipase inhibition antioxidant and anti-inflammatory activities, identifying phenolic compounds, and examining its efficacy in reducing diabetic complications.

Insilico discovery of novel Phosphodiesterase 4 (PDE4) inhibitors for the treatment of psoriasis: Insights from computer aided drug design approaches.

Psoriasis is chronic immune-mediated inflammatory disorder characterized by various comorbidities, erythematous plaques with silvery scale which can lead to psoriatic arthritis. The phosphodiesterase 4 (PDE4) protein is a potential drug target to control Psoriasis. In the current study, pharmacophore-based virtual screening of Diversity library of ChemDiv database was first performed, and then the screened hits were docked to the active site of PDE4 to choose the best binding modes.

In silico discovery of druggable targets in Citrobacter koseri using echinoderm metabolites and molecular dynamics simulation.

Citrobacter koseri causes infection in people who are immunocompromised. Without effective antibiotics, these infections can become severe and life-threatening, so effective drugs are essential to treat these infections. Utilizing subtractive genomics, 2699 ORFs were predicted and translated into amino acid sequences.