Therapeutic effects of Euphorbia altissima on excisional wound model: role of apoptosis, oxidative stress, and inflammatory molecules.

Euphorbia Altissima (E. altissima) is a traditional medicinal herb used for many inflammatory-related health disorders, including skin problems. The study estimates the phytochemicals, acute toxicity, and wound-healing action of methanolic extracts of Euphorbia Altissima (MEEA) in excisional rat models.

A flavonoid Ombuin ameliorates thioacetamide-mediated liver cirrhosis in vivo: biochemical, immunohistochemical, inflammatory approaches.

Liver cirrhosis is posing a global public health concern despite improvements in early diagnosis and therapeutic innovations. The present work evaluates the acute toxicity and prophylactic effects of an O-methylated flavonoid (Ombuin) in thioacetamide (TAA)-induced liver injury in rats and its underlying mechanisms. Thirty Sprague-Dawley rats were aligned into five cages and treated for two months as follows: group A ingested orally 1% CMC + distilled water (i.

A Traditional Gum Exudate From Ameliorates Etha-Nol-Mediated Gastric Ulcer in Rats: Possible Molecular Mechanisms.

(Bene) is a native Mediterranean plant that exudates a resinous therapeutic oleoresin gum used for many inflammatory-related diseases. Therefore, the present study evaluates the acute toxicity and the gastroprotective effects of gum (PAG) on ethanol-mediated gastric ulcers in rats. Sprague Dawley rats (30) were placed in 5 cages: Group A received 10% tween 20; Group B, ulcer control, received 10% tween 20; reference rats (C, received 20 mg/kg omeprazole), groups D and E received 250 and 500 mg/kg of PAG, respectively.

The Gastroprotective Effects of Salvia indica L. and Selenium In Vivo Study.

Salvia indica L. is a traditional therapeutic herb used for numerous health purposes, including intestinal and stomach disorders. The current investigation includes the phytochemical profiling, acute toxicity, and gastroprotective roles of Salvia indica leave extracts (SILE) in combination with selenium (known to facilitate mucosal regeneration, reduce lipid peroxidation, and increase antioxidant activity) in the gastric ulcer animal model.

Prophylactic Effects of Rhamnetin Flavonoid on Indomethacin-Induced Gastric Ulceration by Modulating HSP 70/Bax, SOD/MDA and TNF-α/IL-10.

Rhamnetin is a naturally occurring flavonoid compound found in many wild plant species and indigenous fruits. Despite its numerous biological potentials, such as anti-inflammatory, antioxidant and antimicrobial effects, there is a lack of literature elucidating its gastroprotective action and anticipating molecular mechanism. Natural products can be a good alternative to overcome the side effects and relapses associated with anti-ulcer drugs.

Wild Cherry Prunus microcarpa: Phytochemical Characterization by LCESI MS/MS Technique and its Cytotoxicity, and Pro-apoptotic Actions.

Nutraceuticals and natural products constitute nearly 50% of all cancer treatments due to their maximum efficiency and reduced side effects compared to synthetic chemicals. Thus, the present work investigates the anti-proliferative and apoptotic-stimulating effects of methanolic extracts of wild Prunus microcarpa fruits (MEPMF) and stems (MEPMS) and their phytochemical profiles. The cytotoxicity and pro-apoptotic effects (using MTT and flow cytometry assays) of MEPMF and MEPMS against U-87 MG, PC3, MCF-7, and HT-29 cells and normal human embryonic lung fibroblast cell (WI-38) were analyzed.

Persimmon (Diospyros kaki L.) leaves accelerates skin tissue regeneration in excisional wound model: possible molecular mechanisms.

Persimmon (Diospyros kaki L.) leaves are a traditional medicinal herb used for treating many infectious and inflammatory-related conditions, including wound healing. To validate its traditional use, our study evaluates the acute toxicity and wound-healing effects of methanolic extracts of Persimmon (Diospyros kaki L.

Phytochemical Profiling, Acute Toxicity, and Hepatoprotective Effects of in Thioacetamide-Induced Liver Cirrhosis in Rats.

Evaluation of of the family Boraginaceae during previous investigations determined numerous therapeutic potentials against inflammatory-related diseases. The present study evaluates the phytochemical, acute toxicity, and hepatoprotective effects of methanolic extracts of (MEAL) against thioacetamide (TAA)-induced liver injury in rats. The phytochemical profiling of MEAL followed a Folin-Ciocalteu and 10% AlCl3 procedure using a spectrophotometer.