Diagnostic accuracy of intraoperative neuromonitoring during non-tumor thoracic spine surgeries: A systematic review and meta-analysis.

Background: Thoracic spine surgeries carry a higher risk of neurological complications due to the region's narrow spinal canal and precarious blood supply, making effective monitoring critical. This study offers the first meta-analysis assessing accuracy and prognostic value of Intraoperative neuromonitoring (IONM) in non-tumor thoracic spinal surgeries, filling a key gap in the literature.

Methods: We adhered to PRISMA-DTA guidelines, conducting a PubMed search for relevant studies.

Systematic review of alarm criteria and reversibility in motor-evoked potentials during intramedullary spinal cord tumor resection.

Background/objective: Myogenic motor-evoked potentials (myogenic MEPs) and Direct waves (D-waves) are essential for monitoring motor pathways during intramedullary spinal cord tumor (IMSCT) resections. However, the diagnostic accuracy of alarm criteria and the prognostic value of reversible versus irreversible changes remain unclear. This is the first study addressing this gap.

Evaluating the Diagnostic Benefit of Adding Somatosensory Evoked Potentials to Transcranial Motor-Evoked Potentials Compared to Either Modality Alone in Intramedullary Spinal Cord Tumor Resection: A Systematic Review and Meta-Analysis.

Objective: Evaluate the diagnostic accuracy of somatosensory evoked potentials (SSEPs) and transcranial motor evoked potentials (TcMEPs) in detecting overall neurological deficits when used individually, their pathway-specific accuracy (TcMEPs for motor deficits, SSEPs for sensory deficits), their complementary roles when combined in multimodal intraoperative neurophysiological monitoring (IONM), including cross-modality detection, during intramedullary spinal cord tumor resection.

Methods: A systematic review and meta-analysis were conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Test Accuracy Studies guidelines. PubMed, MEDLINE, Embase, and the Cochrane Library were searched through March 20, 2025.

A Systematic Review and Meta-Analysis to Compare the Diagnostic Accuracy of Direct-Waves and Myogenic Motor-Evoked Potential Neuromonitoring During Intramedullary Spinal Cord Tumor Resection.

Background And Objectives: Intramedullary spinal cord tumor (IMSCT) resection seeks to maximize tumor removal while preserving neurological function, guided by intraoperative neurophysiological monitoring with myogenic motor-evoked potentials (myogenic MEPs) and direct waves (D-wave) recordings. Despite their widespread use, no systematic review has compared their accuracy for predicting immediate, transient, and persistent postoperative motor deficits in IMSCT surgery. This meta-analysis fills this gap by evaluating their diagnostic accuracy.

Role of Immunotherapy in the Management of Advanced Hepatocellular Carcinoma: A Systematic Review.

Introduction: The most prevalent histologic subtype of primary liver cancer, hepato-cellular carcinoma, is also the third most lethal malignancy worldwide and a significant cause of cancer death. When diagnosed, it is frequently too late for curative therapies. To add to the difficulty, it is resistant to conventional systemic therapies like chemotherapy.

"A cross-sectional study to assess stigma associated with tuberculosis in patients, family members, and health care staff in central India.".

Background: Stigma poses significant challenges to tuberculosis control efforts worldwide. India, bearing a substantial burden of tuberculosis cases, grapples with pervasive stigmatizing attitudes towards the disease, hindering timely diagnosis and treatment. This study aims to assess the prevalence and manifestations of tuberculosis-related stigma, shedding light on a critical yet overlooked aspect of tuberculosis management.

Treatment Modalities for Trigeminal Neuralgia and the Need for Vigilance in Monitoring Adverse Drug Events: A Case Report.

Introduction: Trigeminal neuralgia is a rare condition characterised by paroxysms of intense pain in the distribution of the trigeminal nerve. This condition significantly diminishes the patient's quality of life, and the side effects from chronic use of medications for symptomatic relief further exacerbate their distress.

Case Description: The case report discusses a patient diagnosed with Trigeminal Neuralgia who commenced carbamazepine treatment.