Publications by authors named "Rachel Passaro"
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several neurologic diseases. Ceramides are often analyzed in tissue, but this approach fails to resolve cell-type differences in ceramide homeostasis that are likely essential to understanding cell and non-cell autonomous contributions to neurodegeneration.
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- * Researchers used a technique called Wide-bandwidth AFM-based ViscoElastic Spectroscopy (WAVES) to analyze how viscoelastic properties evolve from single cancer cells to larger tumor structures.
- * The study found that established tumors display increased stiffness and unique energy dissipation methods based on fluid-solid interactions, which are linked to cellular density and require a healthy actin cytoskeleton, revealing potential targets for cancer treatment.
In cancer, solid stresses impede the delivery of therapeutics to tumours and the trafficking and tumour infiltration of immune cells. Understanding such consequences and the origin of solid stresses requires their probing in vivo at the cellular scale. Here we report a method for performing volumetric and longitudinal measurements of solid stresses in vivo, and findings from its applicability to tumours.
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