Hydraulic and malleable female-to-male penile implants after phalloplasty in transgender individuals: a retrospective cohort analysis.

Objectives: To provide a comprehensive summary of the surgical outcomes of Zephyr Surgical Implants (ZSI; Geneva, Switzerland) hydraulic and malleable female-to-male (FTM) penile implants (PIs) in transgender patients.

Patients And Methods: All transgender patients who underwent hydraulic (ZSI FTM 475) and malleable (ZSI FTM 100) erectile device implantation between January 2017 and March 2024 were retrospectively identified. Demographics, perioperative characteristics, postoperative complications, and re-operations were recorded.

Prevalence of germline pathogenic variants in 779 patients with metastatic prostate cancer.

Objective: To assess the prevalence of germline pathogenic variants (gPVs) in genes associated with female breast cancer in Dutch patients with metastatic prostate cancer (mPCa).

Patients And Methods: In this prospective multicentre cohort study (n = 15 centres), germline genetic testing of the genes BRCA1, BRCA2, ATM, CHEK2 and PALB2 was offered to patients with mPCa. We assessed the prevalence of gPVs and compared it to a reference population of 16 823 individuals who underwent genetic testing for non-oncological conditions.

Uncovering the Risk: Incidence of Upper Tract Urothelial Carcinoma Following Renal Transplantation in the Netherlands.

Background And Objective: Renal transplant (RTx) recipients appear to have an elevated risk of urothelial carcinoma compared with the general population. While Asia reports a high incidence of upper tract urothelial carcinoma (UTUC) following RTx, this incidence remains underinvestigated in Western countries. The main objective of this study is to determine the incidence of UTUC after RTx in the Netherlands, and to evaluate and compare the incidence and tumour characteristics with those of the general Dutch population diagnosed with UTUC.

Does a kidney stone culture make sense? The findings of microbiological cultures of kidney stones and correlation with stone composition, preoperative urine testing and postoperative SIRS.

Purpose: The study investigates the results of kidney stone cultures and its correlation with preoperative urine tests, stone composition and postoperative systemic inflammatory response syndrome (SIRS) in patients undergoing percutaneous nephrolithotomy (PCNL).

Methods: Data from 338 PCNL procedures performed between January 2018 and September 2023 at two centers in the Netherlands were included for analysis. Preoperative urine tests, kidney stone analysis and the outcome of kidney stone cultures were evaluated in addition to general patient characteristics and surgical information.

How Does Routine Prostate-specific Membrane Antigen Positron Emission Tomography/Computed Tomography Modify the Current Management of Prostate Cancer? A Multidisciplinary View.

Background And Objective: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA-PET/CT) and new treatment modalities have expanded the possibilities for diagnosing and managing metastatic prostate cancer, but have also raised questions about their implementation in daily clinical practice. We sought consensus on definitions, preferred imaging modality for staging, and treatment selection in the era of next-generation imaging.

Methods: A modified Delphi method involved two voting rounds and a face-to-face multidisciplinary meeting with 40 Dutch prostate cancer (PCa) experts.