High-resolution anorectal manometry profile in patients with chronic constipation versus control.

Background And Aims: Studies comparing chronic constipation (CC) and asymptomatic subjects are lacking in our population. This study aimed to compare the high-resolution anorectal manometry (HRAM) profiles of patients with CC and healthy volunteers (HV), as well as patients with functional defecation disorders (FDD) and those without in the constipation group.

Methods: This retrospective comparative study included patients with CC who underwent HRAM and a balloon expulsion test (BET).

Optimization and In-Vitro Characterization of Tetrahydrocurcumin Loaded Niosome for Psoriasis Management.

Introduction: The low solubility and permeability of tetrahydrocurcumin act as a barrier in its therapeutic effectiveness, particularly in the topical treatment of skin diseases like psoriasis.

Method: Niosomes were prepared using thin-film hydration method using span 60, cholesterol as independent variables in Box Behnken design. Particle size, entrapment efficiency and drug loading were taken as dependent variables.

Expression profiling, phenomics, and metabolomics revealed biochemical pathways regulating silicon induced tolerance to metalloid (As, Sb, Ge) toxicity in mungbean (Vigna radiata L. Wilczek).

Metalloid toxicity is one of the principal abiotic stresses faced by plants, leading to the uptake of harmful metalloids disrupting photosynthetic apparatus, interfere with metabolic pathways, and induce oxidative stress. The study evaluates the role of silicon (Si) in mitigating metalloid toxicity by assessing its effect on photosynthetic efficiency, antioxidant defense mechanisms; and overall physiological responses in mungbean (Vigna radiata (L.) Wilczek).

Primary auditory cortex is necessary for the acquisition and expression of categorical behavior.

The primary auditory cortex (ACtx) extracts behaviorally relevant information from complex sounds and supports the categorization of continuous acoustic features into discrete perceptual or behavioral classes. Although ACtx is known to be necessary for certain sound-guided behaviors, how its contributions evolve during learning remains unclear. This evolving role may be shaped by the diversity of its excitatory output pathways, which include multiple classes of projection neurons that transmit sensory information to downstream targets.