Influence of Sex and Diagnosis on Clinical Variables and Neurocognitive Performance in Severe Mental Illness. Results From the PsyCourse Study.

Introduction: Bipolar disorder (BD) and schizophrenia (SZ) are serious mental illnesses (SMI) with overlapping symptoms but distinct differences in onset and course. Sex differences are an area of growing interest in SMI. This study aims to examine potential interactions between sex and diagnosis across a broad range of variables, to compare males and females within SZ and BD, and to investigate sex-specific group differences.

Unravelling the Link Between Body Mass Index and Cognitive Performance in Individuals With Bipolar Disorder and Exploration of PRS Moderation Effect: Findings From the PsyCourse Study.

Introduction: Bipolar disorder (BD) is a severe mental disorder characterized by extreme mood swings, often accompanied by metabolic comorbidities, such as cardiovascular disease, which increase mortality and reduce quality of life. Both metabolic dysfunctions and BD are associated with cognitive dysfunction. Body mass index (BMI) is closely linked to metabolic health and cognitive performance.

Noninvasive assessment of the ventricular arrhythmogenic substrate using electrocardiographic imaging during sinus rhythm: The NIAVAS study.

Background: Late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) identifies structural properties associated with ventricular tachycardia (VT) but lacks functional information. Noninvasive identification of slow conduction regions using electrocardiographic imaging (ECGI) could complement LGE-CMR to aid VT risk stratification.

Objective: This study aimed to evaluate the relationship between ventricular arrhythmogenic substrate and regional ECGI markers during sinus rhythm in patients with ischemic cardiomyopathy (ICM).

Brain metabolite levels in the post-acute stage of anti-NMDA receptor encephalitis and schizophrenia: a longitudinal case-control study.

Background: In-vivo assessment of glutamatergic metabolites in patients with anti-NMDA receptor (NMDAR) encephalitis compared to schizophrenia may help understand the pathophysiology of both conditions.

Methods: Twenty-four-month prospective case-control study including participants with anti-NMDAR encephalitis during the post-acute stage aged 12 to 60 years old, and age and sex-matched individuals with schizophrenia and healthy controls (HC). Single-voxel magnetic resonance spectroscopy was used to estimate brain concentrations of glutamatergic metabolites, myo-inositol and N-acetylaspartate in the left dorso-medial prefrontal region (dmPF) and medial temporal lobe.

Disentangling eye movement desensitization and reprocessing mechanisms of action: The impact of eye movements in the eye blink conditioning task.

Objectives: Eye movement desensitization and reprocessing (EMDR) is an effective evidence-based treatment for post-traumatic stress disorder. However, the therapeutic mechanisms underlying eye movements (EM) remain unclear. This study aimed to investigate the effect of horizontal EM on fear extinction learning in healthy individuals, using an Eye Blink Conditioning (EBC) task.