Spin-Active Polarons Induced Nucleophilic Substitution on Fluorographene for In Situ Fabricating Distinctively 2D-Based Bifunctional Nanocomposites.

Nucleophilic substitution reaction (SR) plays a crucial role in traditional organic chemistry, and its extension into two dimensional (2D) materials has recently created a series of functional materials and advanced applications. However, the traditional SR process is usually indiscriminately copied into existing 2D reaction systems, which tremendously restricts the development of special 2D functional materials and sophisticated applications. In this work, a brand-new spin-active polarons-induced SR process in typical 2D fluorographene (FG) is proposed, where nucleophiles preferentially attack particular oxygen groups for functional grafting, simultaneously inducing the generation of spin-active polarons and subsequently rapid defluorination on the FG nanosheet.

Efficacy and safety of L. combined with antithyroid drugs for hyperthyroidism: a systematic review and meta-analysis.

Objective: To systematically evaluate the efficacy and safety of L. (PVL) preparations combined with antithyroid drugs (ATDs) for the treatment of hyperthyroidism.

Methods: Eight Chinese and English databases were searched for randomized controlled trials (RCTs) comparing PVL preparations combined with ATDs and ATDs for hyperthyroidism treatment.

Cobalt doped Prussian blue modified hollow polydopamine for enhanced antibacterial therapy.

Give the emergence of drug resistance in bacteria resulting from antibiotic misuse, there is an urgent need for research and application of novel antibacterial approaches. In recent years, nanoparticles (NPs) have garnered significant attention due to their potential to disrupt bacteria cellular structure through loading drugs and special mechanisms, thus rendering them inactive. In this study, the surface of hollow polydopamine (HPDA) NPs was utilized for the growth of Prussian blue (PB), resulting in the formation of HPDA-PB NPs.

The reporting quality of randomized controlled trials in Chinese herbal medicine (CHM) formulas for diabetes based on the consort statement and its extension for CHM formulas.

This study aimed to assess the overall reporting quality of randomized controlled trials (RCTs) in Chinese herbal medicine (CHM) formulas for patients with diabetes, and to identify factors associated with better reporting quality. Four databases including PubMed, Embase, Cochrane Library and Web of Science were systematically searched from their inception to December 2022. The reporting quality was assessed based on the Consolidated Standards of Reporting Trials (CONSORT) statement and its CHM formula extension.

Cobalt-doped hollow polydopamine for oxygen generation and GSH consumption enhanced chemo-PTT combined cancer therapy.

Nanotechnology has revolutionized the field of therapeutics by introducing a plethora of nanomaterials capable of enhancing traditional drug efficacy or paving the way for innovative treatment methods. Within this domain, we propose a novel Cobalt-doped hollow polydopamine nanosphere system. This system, incorporating Doxorubicin loading and hyaluronic acid (HA) surface coating (CoHPDA@DOX-HA), is designed for combined tumor therapy.

Yolk-shell shaped Au-BiSheterostructure nanoparticles for controlled drug release and combined tumor therapy.

To fabricate a novel stimuli-responsive system enabling controlled drug release and synergistic therapy, yolk-shell shaped bismuth sulfide modified with Au nanoparticles (Au-BiS) was prepared. The Au-BiSnanomaterial with heterojunction structure exhibited excellent photothermal conversion efficiency and considerable free radicals yield under laser irradiation. The drug delivery capacity was confirmed by co-loading Berberine hydrochloride (BBR) and a phase change material 1-tetradecanol (PCM), which could be responsible for NIR light induced thermal controlled drug release.

Effects of diabetes on the development of radiation pneumonitis.

Radiation pneumonia (RP) is a common adverse reaction to radiation therapy in patients with chest tumors. Recent studies have shown that diabetes mellitus (DM), which can cause systemic multisystem damage, specifically targets lungs, and the incidence of RP in patients with a history of diabetes is higher than that in other patients with tumors who have undergone radiotherapy. DM is an important risk factor for RP in tumor patients undergoing RT, and patients with DM should be treated with caution.