Prognostic significance of cytotoxic-T-lymphocytes to immunosuppressive lymphocytes ratio (CIL) in laryngeal squamous cell carcinoma.

Immunoscore (IS), based on CD3/CD8, has been proposed to characterize the immune landscape of the tumor immune microenvironment and has demonstrated an association with the prognosis of laryngeal squamous cell carcinoma (LSCC). However, traditional IS does not include immunosuppressive cells. The purpose of this study is to evaluate the prognostic performance of cytotoxic-T-lymphocytes to immunosuppressive cells ratio (CIL) in laryngeal squamous cell carcinoma (LSCC) patients.

The impact of health literacy on smoking patterns among male residents: insights from Ningbo City.

Background: This study examined the associations between health literacy and smoking behaviors among residents in Ningbo City, Zhejiang Province, China, investigating both the impact of health literacy on smoking prevalence and intensity, and its potential role in smoking cessation interventions.

Methods: This cross-sectional study analyzed data from 2,948 male participants in the 2023 Health Literacy and Tobacco Use Surveillance Survey. We applied logistic regression models and restricted cubic spline analyses to assess the association between health literacy and smoking behaviors, adjusting for demographic characteristics, socioeconomic factors, and self-reported health status.

CD8 T cells in patients with hypopharyngeal squamous cell carcinoma are susceptible to radiation-induced damage.

Radiotherapy (RT) is a commonly used clinical management for hypopharyngeal squamous cell carcinoma (HPSCC), which represents the most unfavorable prognosis among all subtypes of head and neck squamous cell carcinoma. However, radiation may cause lymphopenia, a significantly adverse event with detrimental prognostic implications for patients. While CD8 T cells are vital in tumor immunity, the specific effects of RT on CD8 T cells as well as the underlying mechanisms have not been clearly elucidated.

Axial Oxygen Ligands Regulating Electronic and Geometric Structure of Zn-N-C Sites to Boost Oxygen Reduction Reaction.

Zn-N-C possesses the intrinsic inertia for Fenton-like reaction and can retain robust durability in harsh circumstance, but it is often neglected in oxygen reduction reaction (ORR) because of its poor catalytic activity. Zn is of fully filled 3d 4s configuration and is prone to evaporation, making it difficult to regulate the electronic and geometric structure of Zn center. Here, guided by theoretical calculations, five-fold coordinated single-atom Zn sites with four in-plane N ligands is constructed and one axial O ligand (Zn-N -O) by ionic liquid-assisted molten salt template method.

Colossal negative thermal expansion in a cucurbit[8]uril-enabled uranyl-organic polythreading framework thermally induced relaxation.

It is an ongoing goal to achieve the effective regulation of the thermal expansion properties of materials. In this work, we propose a method for incorporating host-guest complexation into a framework structure and construct a flexible cucurbit[8]uril uranyl-organic polythreading framework, U(bcbpy)(CB8). U(bcbpy)(CB8) can undergo huge negative thermal expansion (NTE) and has a large volumetric coefficient of -962.

Unveiling Structural Diversity of Uranyl Compounds of Aprotic 4,4'-Bipyridine ,'-Dioxide Bearing O-Donors.

As an aprotic O-donor ligand, 4,4'-bipyridine ,'-dioxide (DPO) shows good potential for the preparation of uranyl coordination compounds. In this work, by regulating reactant compositions and synthesis conditions, diverse coordination assembly between uranyl and DPO under different reaction conditions was achieved in the presence of other coexisting O-donors. A total of ten uranyl-DPO compounds, U-DPO-1 to U-DPO-10, have been synthesized by evaporation or hydro/solvothermal treatment, and the possible competition and cooperation of DPO with other O-donors for the formation of these uranyl-DPO compounds are discussed.

Relationship between health literacy and COVID-19 knowledge: A cross-sectional study.

Background: Health literacy (HL) is a protective factor for some chronic diseases. However, its role in the Coronavirus Disease 2019 (COVID-19) pandemic has not been clarified. This study aims to explore the association between HL and COVID-19 knowledge among residents in Ningbo.

Elevated ETV6 Expression in Glioma Promotes an Aggressive In Vitro Phenotype Associated with Shorter Patient Survival.

: GBM astrocytes may adopt fetal astrocyte transcriptomic signatures involved in brain development and migration programs to facilitate diffuse tumor infiltration. Our previous data show that ETS variant 6 (ETV6) is highly expressed in human GBM and fetal astrocytes compared to normal mature astrocytes. We hypothesized that ETV6 played a role in GBM tumor progression.

Deficiency of Intellectual Disability-Related Gene Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability.

Patients with monoallelic bromodomain and PHD finger-containing protein 1 () mutations showed intellectual disability. The hippocampus has essential roles in learning and memory. Our previous work indicated that was specifically and strongly expressed in the hippocampus from the perinatal period to adulthood.

Activating Titanium Dioxide as a New Efficient Electrocatalyst: From Theory to Experiment.

Though transition-metal-based materials have emerged as the most promising alternatives to Pt-based electrocatalysts in hydrogen evolution reaction (HER), only a few of them (Fe-, Co-, Ni-, W-, and Mo-based materials) are used as efficient HER electrocatalysts, while others are generally considered as HER-inactive materials with poor activities. Here, a theory-guided experiment is carried out to activate titanium dioxide as a new efficient HER electrocatalyst. First-principles simulations indicate that the hydrogen adsorption free energy could be optimized through tuning the structural and electronic properties of TiO.

Silencing expression of PHF14 in glioblastoma promotes apoptosis, mitigates proliferation and invasiveness via Wnt signal pathway.

Background: The plant homeodomain (PHD) finger protein 14 (PHF14) is a vital member of PHD finger protein families. Abnormal expression of PHF14 has been identified in various cancers and is known to be implicated in the pathogenesis of tumors. This study investigates the role and the underlying mechanisms of PHF14 in GBM (glioblastoma multiforme).

Design Superior Alkaline Hydrogen Evolution Electrocatalyst by Engineering Dual Active Sites for Water Dissociation and Hydrogen Desorption.

In alkaline media, the water-dissociation-related Volmer process always suppresses the hydrogen formation/desorption process, which makes it challenging to develop non-noble-metal alkaline electrocatalysts with excellent catalytic activity. Here, we proposed a two-pronged strategy to simultaneously promote the kinetic process of both water dissociation and hydrogen desorption with the Co-doped WO/amorphous CoW hybrid electrocatalyst. Impressively, the optimized hybrid exhibits an outstanding hydrogen evolution reaction (HER) activity with the quite small Tafel slope of 19.

Substituent effects in the decarboxylation reactions of coordinated arylcarboxylates in dinuclear copper complexes, [(napy)Cu(OCCHX)].

A combination of gas-phase ion trap mass spectrometry experiments and density functional theory (DFT) calculations have been used to examine the role of substituents on the decarboxylation of 25 different coordinated aromatic carboxylates in binuclear complexes, [(napy)Cu(OCCHX)], where napy is the ligand 1,8-naphthyridine (molecular formula, CHN) and X = H and the ortho ( o), meta ( m) and para ( p) isomers of F, Br, CN, NO, CF, OAc, Me and MeO. Two competing unimolecular reaction pathways were found: decarboxylation to give the organometallic cation [(napy)Cu(CHX)] or loss of the neutral copper benzoate to yield [(napy)Cu]. The substituents on the aryl group influence the branching ratios of these product channels, but decarboxylation is always the dominant pathway.

Plasma-Assisted Synthesis of Self-Supporting Porous CoNPs@C Nanosheet as Efficient and Stable Bifunctional Electrocatalysts for Overall Water Splitting.

The utilization of a highly active and robust bifunctional catalyst for simultaneously producing H and O is still a major challenging issue, which is vital for improving the efficiency of overall water splitting. Herein, we employ a novel plasma-assisted strategy to rapidly and conveniently synthesize the three-dimensional (3D) porous composite nanosheets assembled on monodispersed Co nanoparticles encapsulated in a carbon framework (CoNPs@C) on a carbon cloth. Such a novel 3D hierarchical porous nanosheet improves the exposure and accessibility of active sites as well as ensures high electroconductibility.