Rh-catalyzed enantioselective hydrosilylation of unactivated alkenes.

Here, we report a highly efficient rhodium-catalysed enantioselective hydrosilylation of unactivated alkenes, achieving excellent regioselectivity and high enantioselectivity. The use of a commercially available chiral ferrocene-based phosphine-oxazoline ligand was crucial in achieving excellent chiral induction and high reactivity with undirected unactiviated alkenes, delivering Si-stereogenic monohydrosilanes in high yields and excellent enantioselectivities. This protocol represents a robust, scalable method for the enantioselective synthesis of Si-stereogenic monohydrosilanes, featuring a low catalyst loading, a broad substrate scope and exceptional functional group and heterocycle tolerance.

Chan-Lam Reaction and Lewis Acid Promoted 1,3-Rearrangement of N-O Bonds to Prepare -(2-Hydroxyaryl)pyridin-2-ones.

We describe the difunctionalization of arylboronic acids to prepare various -(2-hydroxyaryl)pyridin-2-ones in good yields using -hydroxypyridin-2-ones as the oxygen and nitrogen sources through a copper(II)-catalyzed Chan-Lam reaction and subsequent BF-promoted selective 1,3-rearrangement of N-O bond in a one-pot procedure. Mechanistic studies reveal that the 1,3-rearrangement selectivity is controlled by the formation of the key aryloxypyridinium salt. The obtained products are easily converted to various useful pyridin-2-one scaffolds.

Radical alkylation of para-quinone methides with 4-substituted Hantzsch esters/nitriles via organic photoredox catalysis.

A novel photocatalytic protocol is herein described for the preparation of functionalized phenols via radical alkylation of para-quinone methides under transition-metal-free conditions. The reaction is external oxidant free and performed at ambient temperature upon visible light irradiation, allowing the access to various desired products in satisfactory yields. The readily available 4-alkyl-1,4-dihydropyridines serve as the effective alkyl radical precursors.

Diverse Transformation of Vinyl Azides with 2,2,6,6-Tetramethyl- N-oxopiperidinium.

A 2,2,6,6-tetramethyl- N-oxopiperidinium (TEMPO)-mediated three-component diverse transformation of vinyl azides under metal-free conditions is described. The reaction protocols are operationally simple and conducted at ambient temperature, allowing to access various TEMPO-trapped ketones, amides, and α-alkoxyalkyl azides. Preliminary mechanistic studies indicate that an alkene radical cation-mediated radical-radical cross-coupling C-O bond formation could be involved.

Modeling the Self-Assembly of Bolaamphiphiles under Nanoconfinement by Coarse-Grained Molecular Dynamics.

Novel and complex nanostructures of amphiphiles assemblies facilitate realizing of many practical applications in nanotechnologies. Under different physical conditions, amphiphiles can form various morphologies. In this article, the self-assembly of bolaamphiphiles was investigated under the cylindrical confinement of carbon nanotubes by coarse-grained molecular dynamics simulation.

Effect of hydrophobic mismatch on domain formation and peptide sorting in the multicomponent lipid bilayers in the presence of immobilized peptides.

In the plasma membranes, many transmembrane (TM) proteins/peptides are anchored to the underlying cytoskeleton and/or the extracellular matrix. The lateral diffusion and the tilt of these proteins/peptides may be greatly restricted by the anchoring. Here, using the coarse-grained molecular dynamics simulation, we investigated the domain formation and peptide sorting in the ternary lipid bilayers in the presence of the immobilized peptide-grid and peptide-cluster.

1-Quasiconformal mappings and CR mappings on Goursat groups.

We show that 1-quasiconformal mappings on Goursat groups are CR or anti-CR mappings. This can reduce the determination of 1-quasiconformal mappings to the determination of CR automorphisms of CR manifolds, which is a fundamental problem in the theory of several complex variables.

Interplay between curvature and lateral organization of lipids and peptides/proteins in model membranes.

Membrane curvature plays a crucial role in the realization of many cellular membrane functions such as signaling and trafficking. Here, using coarse-grained molecular dynamics (MD) simulation, we present an effective method of producing curved model membranes and systematically investigated the interplay between the curvature and lateral sorting of lipids and transmembrane (TM) peptides/proteins in the model membranes. We first confirmed the experimental results of the lateral organization of lipid domains in curved ternary membranes.