nNOS/NO in nucleus accumbens medicates NKCC1 in neonatal repetitive pain.

Exposure to repetitive pain procedures in the neonatal intensive care unit (NICU) leads to long-term effects on pain response in adults. However, the underlying mechanisms in the central nervous system (CNS) are unclear. This study aimed to invesitgate the role of neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) in the nucleus accumbens (NAc), including increased protein expression, cell number, and specific enzyme activity, which helps accelerate pain.

Inhibition of hippocampal cyclin-dependent kinase 5 activity ameliorates learning and memory dysfunction in a mouse model of bronchopulmonary dysplasia.

Aims: Oxygen therapy plays a vital role in the development of bronchopulmonary dysplasia (BPD), which is the independent risk factor for neurodevelopment deficits in premature infants. However, the effect of hippocampal cyclin-dependent kinase 5 (CDK5) on BPD-associated neurodevelopment deficits is not fully understood.

Methods: Mice were placed in a hyperoxia chamber from postnatal Day 1 to Day 7.