Recent advances in nanopharmaceutical strategies for cancer treatment.

Next-generation cancer nanomedicines are revolutionizing therapeutic precision through multifunctional, adaptive, and tumor-specific strategies. This review discusses emerging innovations in cancer nanomedicine, including stimuli-responsive nanomedicines, biomimetic nanomedicines, nanozymes, nanovaccines, immunotherapy, and diagnostic-integrated theranostics. These platforms allow for spatially controlled therapy, deep tumor penetration, and immune reprogramming with minimal systemic toxicity.

Tretinoin loaded NLCs-based sunscreen cream; preparation and characterization.

FDA has recognized tretinoin as the gold standard for skin anti-aging products but it has the disadvantage of being a strong irritant and unstable in light. Nanostructured lipid carriers (NLCs) are advanced, second-generation solid lipid nanoparticles with the intriguing feature of acquiring the properties of physical sunscreens in terms of UV ray scattering. Thus, this study was designed to formulate a tretinoin-loaded NLCs-based sunscreen cream to potentiate the photo-stability of tretinoin.

Corrigendum: Chitosan/Xanthan Gum based hydrogels as potential carrier for an antiviral drug: Fabrication, characterization, and safety evaluation.

[This corrects the article DOI: 10.3389/fchem.2020.

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs.

The low aqueous solubility of many drugs reduces their bioavailability in the blood. Oils have been used for centuries to enhance the solubility of drugs; however, they can disturb the lipid profile of the patients. In this study, self-nanoemulsifying drug delivery systems of omega-3 fatty acids-rich oils are prepared and optimized for the delivery of lipophilic drugs.

Chitosan/Xanthan Gum Based Hydrogels as Potential Carrier for an Antiviral Drug: Fabrication, Characterization, and Safety Evaluation.

This study investigated the use of pure polymer chitosan (CS), xanthan gum (XG), monomer 2-acrylamido-2-methylpropane sulfonic acid (AMPS) and initiator potassium persulfate (KPS) as drug carrier system crosslinked through N' N'-methylene bis-acrylamide (MBA) for controlled drug delivery of acyclovir (ACV). ACV is highly effective and selective antiviral drugs used for prophylaxis and treatment against herpes simplex viruses (HSV) infections. Present oral marketed formulations are associated with number of side effects and shortcomings which hampered its clinical effectiveness.

Synthesis and evaluation of topical hydrogel membranes; a novel approach to treat skin disorders.

The aim of the study was to synthesize and evaluate chitosan-based topical cross-linked hydrogel membranes of mupirocin for new pharmaceutical controlled release application. These cross-linked structured membranes were synthesized by modification of free radical polymerization. Low molecular weight (LMW) chitosan is cross-linked with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with a crosslinker N,N-methylenebisacrylamide (MBA).

Development and evaluation of eudragit based microparticles of dexibuprofen for site specific drug release.

The main purpose of work was to formulate dexibuprofen loaded eudragit L-100 micro particles to acquire site specific delivery of dexibuprofen. Micro particles were formulated by an emulsion solvent evaporation method. Four formulations F1, F2, F3 and F4 having drug to polymer ratio 1:1, 1:2, 1:3 and 1:4, respectively were prepared and characterized.

Synthesis of β-cyclodextrin hydrogel nanoparticles for improving the solubility of dexibuprofen: characterization and toxicity evaluation.

Objective: This study was aimed to enhance aqueous solubility of dexibuprofen through designing β-cyclodextrin (βCD) hydrogel nanoparticles and to evaluate toxicological potential through acute toxicity studies in rats.

Significance: Dexibuprofen is a non-steroidal analgesic and anti-inflammatory drug that is one of safest over the counter medications. However, its clinical effectiveness is hampered due to poor aqueous solubility.