Method for fetal ultrasound image classification using pseudo-labelling with PCA-KMeans and an attention-augmented MobileNet-LSTM model.

Accurate classification of fetal ultrasound images is critical for early diagnosis, yet remains challenging due to limited labeled data and high inter-class variability. This study presents a robust deep learning framework that combines a MobileNet backbone with multi-head self-attention and LSTM layers to enhance feature learning and temporal context. To address data scarcity and imbalance, unsupervised clustering was employed using Principal Component Analysis (PCA) for dimensionality reduction and K-means (k=4) for pseudo-label generation.

Hierarchical cross-modal attention and dual audio pathways for enhanced multimodal sentiment analysis.

This paper presents a new architecture for multimodal sentiment analysis exploiting hierarchical cross-modal attention mechanisms, as well as two parallel lanes for audio analysis. Traditional sentiment analysis approaches are mainly based on text data, which can be inefficient as valuable sentiment information may reside within images and audio. Aiming at solving this issue, the model provides a unified framework that integrates three modalities (text, image, audio) based on BERT text encoder, ResNet50 visual features extractor and hybrid CNN-Wav2Vec2.

Uptake and patient-related outcomes of mainstreaming genetic testing: a systematic review and meta-analysis.

Objective: Mainstreaming genetic testing refers to genetic testing for cancer susceptibility genes following cancer diagnosis, which is provided by nongenetic health professionals of the cancer-treating team. Mainstreaming can be used to guide cancer treatment and secondary cancer prevention in the patient and to identify carriers in the family members of patients who test positive through cascade testing. We aimed to assess uptake and patient-reported outcomes of mainstreaming genetic testing.

Synthesis of -dA Damaged DNAs to Probe the Replication Ability of Human Translesion Polymerases.

The DNA adducts formed by the alkenylbenzene natural products, safrole (SF) and methyleugenol (MEG) are primarily attributed to their reported carcinogenic properties. Herein, we report a concise strategy to access -Ac-SF/MEG-dA phosphoramidites, which were selectively incorporated into DNA oligonucleotides by solid-phase DNA synthesis. The replication studies using human polymerases hpolκ and hpolη showed that both polymerases replicate these adducts error-free, which indicates that these polymerases do not contribute to the adduct-induced mutagenicity.

Synthesis of --isosafrole-dG-adduct Bearing DNAs and the Bypass Studies with Human TLS Polymerases κ and η.

Safrole is a natural product present in many plants and plant products, including spices and essential oils. During cellular metabolism, it converts to a highly reactive trans-isosafrole (SF) intermediate that reacts with genomic DNA and forms -SF-dG and -SF-dA DNA adducts, which are detected in the oral tissue of cancer patients with betel quid chewing history. To study the SF-induced carcinogenesis and to probe the role of low fidelity translesion synthesis (TLS) polymerases in bypassing SF adducts, herein, we report the synthesis of -SF-dG modified DNAs using phosphoramidite chemistry.

Human Translesion Synthesis Polymerases polκ and polη Perform Error-Free Replication across -dG Methyleugenol and Estragole DNA Adducts.

The secondary metabolites of polypropanoids, methyleugenol (MEG), and estragole (EG), found in many herbs and spices, are commonly used as food flavoring agents and as ingredients in cosmetics. MEG and EG have been reported to cause hepatocarcinogenicity in rodents, human livers, and lung cells. The formation of -dG and -dA DNA adducts is primarily attributed to the carcinogenicity of these compounds.

Rare case of high-grade endometrial stromal sarcoma metastasising to inferior vena cava and right atrium.

Endometrial stromal sarcomas (ESSs) are a rare form of uterine malignancy representing <10% of all uterine sarcomas and <1% of all primary malignant tumours of the uterus. Invasion of the vascular system by low-grade ESS has been reported in the literature. Here we report the first case of a high-grade ESS invading the pelvic and gonadal vein and extending through the inferior vena cava to the right atrium, the diagnostic challenges and multidisciplinary management of the case.

Calcifying epithelial odontogenic tumour of the maxilla - A rare case report.

A calcifying epithelial odontogenic tumour (CEOT) is a rare benign odontogenic tumour, which was first described by J. J. Pindborg in 1955, hence it is also called the Pindborg tumour.

Knowledge, Attitudes, and Perceived Barriers of Healthcare Providers toward Early Mobilization of Adult Critically Ill Patients in Intensive Care Unit.

Background: Early mobilization (EM) of critically ill adult patients in intensive care units (ICUs) is a newer concept. It is known to improve overall outcomes, but little is known regarding the attitude and knowledge of healthcare providers (HCPs) and multidisciplinary barriers to its use in the Indian scenario.

Aims And Objectives: To study the knowledge and attitude of HCPs in ICU about the EM of adult patients who are critically ill and identify perceived barriers to the application of EM.

Androgen receptor mediated epigenetic regulation of CRISP3 promoter in prostate cancer cells.

Cysteine-rich secretory protein 3 (CRISP3) is one of the most upregulated genes in prostate cancer. Androgen receptor (AR) plays an important role not only in initial stages of prostate cancer development but also in the advanced stage of castration-resistant prostate cancer (CRPC). Role of AR in regulation of CRISP3 expression is not yet known.

Insulin signaling pathway protects neuronal cell lines by Sirt3 mediated IRS2 activation.

Cellular stress like ER and oxidative stress are the principle causative agents of various proteinopathies. Multifunctional protein PARK7/DJ-1 provides protection against cellular stress. Recently, insulin/IGF also has emerged as a neuro-protective molecule.

Enhancing clinical measures of postural stability with wearable sensors.

About 30% of individuals over the age of 65, and 50% over age 80, fall at least once per year. Fall-related injuries cost the Canadian health care system $2.8 billion annually.