Nano-biohybrids with cell-penetrating peptides: A molecular trojans for glioblastoma precision medicine.

Glioblastoma (GBM), being a formidable disease, has emerged as a ticking time bomb owing to the unavailability of effective treatment modalities, poor prognosis, and limited life expectancy. For effective GBM treatment, intracellular delivery of therapeutics is a dire necessity, which is hindered by the blood-brain barrier (BBB) and blood-tumor barrier (BTB). Nanocarriers (NCs) have emerged as novel biomedical tools for delivering therapeutics for the last so many years.

Nano-chameleons: A review on cluster of differentiation-driven immune cell-engineered nanoarchitectonics for non-small cell lung cancer.

Cancer, being one of the most outrageous diseases, contributed to 48 % of the mortality in 2022, with lung cancer leading the race with a 12.4 % incidence rate. Conventional treatment modalities like radio-, chemo-, photo-, and immunotherapy employing nanocarriers often face several setbacks, such as non-specific delivery, off-site toxicity, rapid opsonization via the host immune system, and greater tumor recurrence rates.

Harnessing Folate Receptors: A Comprehensive Review on the Applications of Folate-Adorned Nanocarriers for the Management of Melanoma.

The advancement in exclusively tailored therapeutic delivery systems has escalated a great deal of interest in targeted delivery to augment therapeutic efficacy and to lessen adverse effects. The targeted delivery approach promisingly helps to surmount the unmet clinical needs of conventional therapies, including chemoresistance, limited penetration, and side effects. In the case of melanoma, various receptors were overexpressed on the tumor site, among which folate receptor (FR) targeting is considered to be a progressive approach for managing melanoma.

Unveiling the revolutionary approach for psoriasis management: Leveraging the breakthrough capabilities of hyaluronic acid.

Psoriasis is an unexceptional autoimmune-mediated, inflammatory skin disorder impacting systemic skin functions. The pathophysiology of psoriasis comprises hyperproliferation of cells on the epidermis, differentiation of keratinocytes, and the impaired barrier function of the epidermal layer of the skin, developing in the thickening of the epidermal layer. From a range of inflammatory mediators concerned during the pathogenesis of psoriasis, IL-17, -23, and TNF-α exert a significant influence on the upregulation of the symptoms.