Publications by authors named "Prachi Parikh"
Objective: Epilepsy surgery needs predictive features that are easily implemented in clinical practice. Previous studies are limited by small sample sizes, lack of external validation, and complex computational approaches. We aimed to identify and validate visually stereo-electroencephalography (SEEG) features with the highest predictive value for surgical outcome, and assess the reliability of their visual extraction.
View Article and Find Full Text PDFBackground: Closed-loop responsive neurostimulation (RNS) is an established non-resective neuromodulatory therapy for individuals with drug-resistant epilepsy (DRE). RNS systems are typically programmed to detect and respond to predefined seizure onset patterns, with detector settings often remaining unchanged for extended periods.
Aims: To describe the delayed recognition of a novel seizure onset pattern in the acute and chronic clinical settings.
Seizures in people with dementia (PWD) are associated with faster cognitive decline and worse clinical outcomes. However, the relationship between ongoing seizure activity and post-mortem neuropathology in PWD remains unexplored. We compared post-mortem findings in PWD with active, remote and no seizures using multicentre data from 39 Alzheimer's Disease Research Centres from 2005 to 2021.
View Article and Find Full Text PDFSleep-related hypermotor seizures originating from the occipital lobe.
Epileptic Disord
December 2024
Article Synopsis
- The study presents two cases of sleep-related hypermotor epilepsy (SHE) linked to the occipital lobe in young females who experienced frequent sleep seizures and occasional tonic-clonic seizures with hypermotor movements.
- SEEG monitoring revealed an epileptogenic zone in the occipital lobe, highlighting that most seizures occurred during NREM sleep.
- This research suggests that occipital lobe seizures should be considered in diagnosing SHE, particularly when there are unique symptoms like visual aura and delayed motor responses.
Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study.
BMJ Neurol Open
August 2024
Introduction: Epilepsy surgery is the only curative treatment for patients with drug-resistant focal epilepsy. Stereoelectroencephalography (SEEG) is the gold standard to delineate the seizure-onset zone (SOZ). However, up to 40% of patients are subsequently not operated as no focal non-eloquent SOZ can be identified.
View Article and Find Full Text PDFA line-field confocal optical coherence tomography (LC-OCT) combines confocal microscopy and optical coherence tomography into a single, rapid, easy-to-use device. This meta-analysis was performed to determine the reliability of LC-OCT for diagnosing malignant skin tumors. PubMed, EMBASE, Web of Science databases, and the Cochrane Library were searched for research studies in the English language from inception till December 2023.
View Article and Find Full Text PDFSpesolimab: A Review of the First IL-36 Blocker Approved for Generalized Pustular Psoriasis.
Ann Pharmacother
February 2025
Objective: This article reviews clinical trial data that assesses the safety, efficacy, and clinical application of spesolimab, an interleukin-36 (IL-36) blocker, for the treatment of generalized pustular psoriasis (GPP).
Data Sources: A review of the literature was conducted using the search terms: "spesolimab," "BI 655130," and "spevigo" in MEDLINE (PubMed) and Clinicaltrials.gov from January 1, 1950 to October 31, 2023.
Article Synopsis
- The EEG is a crucial tool for diagnosing neurological conditions, especially epilepsy, but it's important to recognize normal waveforms to avoid misinterpretation.
- A study at Duke University analyzed various normal EEG waveforms using advanced source localization technology on samples collected from 2014 to 2019.
- Findings indicated specific brain region associations for different waveforms, such as vertex waves in the frontocentral area and sleep spindles in the deep midline central region, enhancing understanding of their physiological origins despite sample size limitations.
Background: We aimed to evaluate the significance of electromyographic findings in the intrinsic foot muscles (IFMs) of patients with skin biopsy proven small fiber neuropathy (SFN).
Methods: This was a single-center retrospective analysis of patients who underwent skin biopsy for intra-epidermal nerve fiber density (IENFD) measurement and electrodiagnostic (EDX) study for evaluation of polyneuropathy.
Results: A total of 1416 patents with normal lower extremity EDX studies proximal to the foot were included.
Purpose: Telemedicine is increasingly utilized in the evaluation of critically ill patients, including those with decreased level of consciousness (LOC) or coma. Improving access to providers with neurologic expertise affords earlier triage and directed patient management. However, objective data regarding the reliability of using standardized coma scales, traditionally employed at the bedside for remote assessment, are largely lacking.
View Article and Find Full Text PDFBackground: The majority of people with epilepsy have a good prognosis and their seizures can be well controlled with the use of a single antiepileptic agent, but up to 30% develop refractory epilepsy, especially those with partial seizures. In this review we summarise the current evidence regarding zonisamide, when used as an add-on treatment for drug-resistant partial epilepsy.
Objectives: To evaluate the efficacy and tolerability of zonisamide when used as an add-on treatment for people with drug-resistant partial epilepsy.