Transsylvian versus transcortical approach to insular glioma: analysis of the extent of resection and postoperative neurological complications in propensity score-matched comparative patient cohorts.

Objective: This study aimed to analyze the comparative tumor resection rates and complication profiles of the transsylvian (TS) and transcortical (TC) approaches to the insular glioma (IG) and emphasize the concept of onco-microneurosurgery as a key to surgical success in these difficult areas.

Methods: A retrospective analysis of a single surgeon's prospectively maintained data of surgically resected, newly diagnosed IGs in adult patients (≥ 18 years old) was conducted. Propensity score matching was performed with a tolerance limit of 0.

Effect of COVID-19-related Lockdown on Headache in Adults: A Report of a Survey.

Background: The majority of electronic (e)-consultations during the COVID-19 lockdown were for headache, which gave an impression of an increase in headache frequency during the lockdown. However, hospital consultation cannot provide a clear picture due to inherent selection bias.

Objective: This survey was aimed to evaluate the effect of COVID-19-related lockdown on headache in adults previously suffering from headache.

Nasal DUOPAP vs nasal continuous positive airway pressure in preterm neonates with respiratory distress syndrome - A randomized control trial.

Background: There has been major shift in choice of respiratory support in preterm babies from invasive to non-invasive. There are various modes of non-invasive respiratory support. The comparative efficacy of one mode over another is an important research area.

Transcutaneous electric nerve stimulation in restless leg syndrome with cirrhosis: a pilot study.

Background: The study aimed to evaluate the effect of transcutaneous electric nerve stimulation (TENS) on restless leg syndrome (RLS) severity, sleep, quality of life, anxiety, and depression in liver cirrhosis patients.

Research Design And Methods: This was single-arm, open label, pilot study. Cirrhosis patients with RLS were evaluated with International RLS Score (IRLSS, scored 0-40 for severity) at baseline and 1, 2, 4, 6 weeks.

Immunohistochemistry in Progressive Familial Intrahepatic Cholestasis (PFIC): Bridging Gap Between Morphology and Genetics.

Background/aims: A heterogeneous group of disorders caused by bile secretion and transport defects is progressive familial intrahepatic cholestasis (PFIC). PFIC has various subtypes with different presentations, laboratory findings, treatments, progression, and prognosis. Genetic analysis is the gold standard for diagnosis but is costly, time-consuming, and not readily available.

A new therapeutic paradigm: radioiodine combined with lenvatinib for radioiodine-avid metastatic well-differentiated thyroid cancer.

Purpose: Metastatic well-differentiated thyroid cancer (WDTC) has significant morbidity and mortality. Multidisciplinary treatment, including high-dose radioiodine therapy (HDRI), has seldom complete response. Concerns are side effects, radioiodine refractoriness, and systemic metastasis.

Psychoactive substance use among medical and paramedical undergraduate students of Lucknow.

Background: Psychoactive drugs are substances that, when taken in or administered into one's system, affect mental processes like perception, consciousness, cognition, mood, and emotions. The use of psychoactive substances often starts at a young age. This study aimed to estimate the prevalence of psychoactive substance use among medical and paramedical undergraduate students of Lucknow.

Maternal Mortality due to Pregnancy-Related Acute Kidney Injury (PRAKI); A Study of the Epidemiological Factors and Possible Solutions.

Objective: This prospective observational study aimed to explore the epidemiology, causes, and outcomes of Pregnancy-Related Acute Kidney Injury (PRAKI) in a tertiary care center in North India and identify risk factors for mortality.

Methods: We enrolled adult obstetric patients with PRAKI according to Kidney disease improving global outcomes criteria between February 2021 and April 2022. Data on demographic characteristics, clinical features, causes of PRAKI, and outcomes were collected.

Role of Gene Xpert MTB/RIF assay for detecting tuberculous spondylitis in specimens obtained by CT-guided aspiration/biopsy and spectrum of imaging findings in spinal tuberculosis.

Objective: To evaluate the utility of the GeneXpert MTB/RIF assay for the diagnosis of tuberculous spondylitis in samples obtained by CT-guided aspiration/biopsy. The effect of anti-tubercular treatment, specimen type, and imaging findings on laboratory results was also assessed along with a comparison of imaging findings in tubercular versus non-tubercular cases.

Methods: This prospective observational study, planned for CT-guided aspiration/ biopsy, included 70 adults with suspected tuberculous spondylitis.

Leveraging eCAP thresholds in a logistic model to predict speech outcomes after implantation in anomalous cochlea.

Background: Pediatric cochlear implant (CI) recipients with cochlear malformations face challenges due to variable speech recognition outcomes.

Aims/objectives: This study assesses the predictive value of intraoperative electrically evoked compound action potential (eCAP) thresholds, residual hearing, age at implantation, Intelligent Quotient (IQ), and malformation type for speech recognition outcomes.

Material And Methods: A prospective cohort of 52 children (aged 1-4 years) with cochlear malformations who underwent CI between 2016 and 2024 was analyzed.

Propensity score analysis of adjuvant therapy in radically resected gallbladder cancers: A real world experience from a regional cancer center.

Backgrounds/aims: Given the high mortality associated with gallbladder cancer (GBC), the efficacy of adjuvant therapy (AT) remains controversial. We audited our data over an 11-year period to assess the impact of AT.

Methods: This study included all patients who underwent curative resection for GBC from 2007 to 2017.

Metabolic markers derived from 18 F-FDG PET/CT in suspected recurrent ovarian carcinoma: predictive value for disease burden and prognosis.

Objective: This study aims to assess the role of 18 F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) in suspected recurrent ovarian carcinoma. Several clinical and PET parameters were assessed to evaluate disease burden and prognosis.

Methods: We did a single-center, retrospective study in patients with suspected recurrent ovarian carcinoma who underwent 18 F-FDG PET/CT.

A Randomized Study of Consolidation Chemoradiotherapy Versus Observation After First-line Chemotherapy in Advanced Gallbladder Cancers: RACE-GB study.

Purpose: Chemotherapy (CT) is the standard of care for patients presenting with unresectable advanced gallbladder carcinoma (GBC) but their prognosis remains poor. The value of consolidation CT and radiation therapy (RT) after initial CT is uncertain. We, therefore, conducted a single-center open-label randomized trial evaluating consolidation CTRT versus observation after 4 cycles of CT in patients whose disease did not progress during CT (partial responders/stable disease).

Skin Flap Necrosis in Inguinal Lymph Node Dissection.

Inguinal skin flap necrosis (SFN) is a significant clinical problem associated with inguinal lymph node dissection (ILND). The aetiology of SFN is multifactorial, and its manifestations vary widely. Thermal damage caused by electrocautery during the elevation of the skin flap may contribute to this problem, which has not been studied previously.

The histological grading of fibrosis in Budd-Chiari syndrome: A chronic liver disease, different from others.

Introduction: Budd-Chiari syndrome (BCS) is an uncommon disease caused by hepatic venous outflow obstruction. They can result in centrilobular fibrosis, nodular regenerative hyperplasia and cirrhosis. Assessing liver fibrosis is crucial for determining the stage of BCS, predicting disease progression and guiding treatment decisions.

Prognosis and ablation success in thyroid cancer: overcoming the challenges of incomplete clinical profiles.

Background: Differentiated thyroid carcinoma (DTC) is managed by surgery followed by radioiodine (RAI) therapy in most intermediate and high-risk patients. Most nonmetastatic patients have excellent treatment responses and have long-term disease-free status. A lack of comprehensive medical services in resource-limited nation leads to attrition of critical clinical prognostication information.

Acupressure On Chemotherapy-Induced Nausea and Vomiting among Breast Cancer Patients: A Systematic Review and Meta-analysis.

Background: Nausea and vomiting are one of the common and distressing side effects of chemotherapy in breast cancer patients often impacting their quality of life and treatment adherence. The purpose of this systematic review and meta-analysis was to determine whether acupressure is effective in treating breast cancer patients' acute nausea and vomiting brought on by chemotherapy as well as delayed nausea and vomiting.

Methods: We systematically searched for Randomized controlled trials and quasi-experimental studies in PubMed, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Clinical Key, Web of Science, EMBASE, and Scopus.

Distinctive toxic repercussions of polystyrene nano plastic towards aquatic non target species Nitrobacter vulgaris, Scenedesmus sp and Daphnia magna.

The widespread application of plastics and its eventual degradation to micro-sized or nano-sized plastics has led to several environmental concerns. Moreover, nanoplastics can easily cascade through the food chain accumulating in the aquatic organisms. Thus, our study focussed on investigating the hazardous impact of nano-sized plastics on aquatic species including Nitrobacter vulgaris, Scenedesmus sp, and Daphnia magna.

Cognitive Functioning Among Community-dwelling Older Adults in Rural Population of Lucknow and Its Association with Comorbidities.

Background: The transitional state between normal aging and dementia is known as Cognitive impairment (CI) where a person has memory complaints and objective evidence of CI but no evidence of dementia. With the globe undergoing a "demographic transition," the magnitude of neurodegenerative disorders is rising. In India, 27.

"Quality of life is impaired in children with chronic pancreatitis: A multicenter study".

Background And Objectives: The impact of chronic pancreatitis (CP) on quality of life (QOL) of children is not well established. Our objective was to evaluate the QOL, identify contributing factors, and determine the prevalence of anxiety and depression in children with CP in India.

Methods: Children (8-18y old) with CP were prospectively enrolled across three pediatric gastroenterology centres in India.

To compare the efficacy of the between-the-fingers grip with the conventional pen-holding grip to hold an endotracheal tube for orotracheal intubation: A randomised controlled trial.

Background And Aims: Correctly holding the endotracheal tube (ETT) is essential for successful tracheal intubation. The study's primary objective was to compare the between-the-fingers grip with the conventional pen-holding grip regarding the number of attempts required for orotracheal intubation and usage of external aids.

Methods: Three hundred patients undergoing elective surgeries under general anaesthesia were randomised according to the method to hold the ETT to Group C (conventional grip) and Group M (modified, between-the-fingers grip) during oro-tracheal intubation.

Predictors of Toxicity in a Randomized Study of Consolidation Chemoradiation Versus Observation After First Line Chemotherapy in Advanced Gall Bladder Cancers.

Purpose: Gall bladder cancers (GBC) usually presents in advanced stage. First-line chemotherapy (CT) is the standard of care, and there is no other option for responders than to wait for disease progression. We conducted a randomized study of consolidation chemoradiation (CTRT) versus observation in responders to first line CT (NCT05493956), which showed an improvement in overall survival by 6 months and therefore is practice changing.