BrSPR-20-P1 peptide isolated from sp. developed into liposomal hydrogel as a potential topical antimicrobial agent.

A novel BrSPR-20-P1 antimicrobial peptide (P1-AMP; NH-VVVNVLVKVLPPPVV-COOH) isolated from sp. SPR-20 was encapsulated in a liposome containing varying proportions of l-α-phosphatidylcholine (PC) and cholesterol (CH). P1-AMP liposomes were incorporated into a chitosan hydrogel to achieve a peptide concentration of 0.

In Vitro Evaluation of Colistin Conjugated with Chitosan-Capped Gold Nanoparticles as a Possible Formulation Applied in a Metered-Dose Inhaler.

Inhaled colistin is used to treat pneumonia and respiratory infections through nebulization or dry powder inhalers. Nevertheless, the development of a metered-dose inhaler (MDI) for colistin, which could enhance patient convenience and treatment efficacy, has not yet been developed. Colistin is known for its ability to induce cellular toxicity.

Silver Nanoparticles Conjugated with Colistin Enhanced the Antimicrobial Activity against Gram-Negative Bacteria.

Colistin is a potent peptide antibiotic that is effective against Gram-negative bacteria. However, nephrotoxicity limited its clinical use. Silver nanoparticles (AgNPs) have gained attention as a potential antimicrobial agent and nanodrug carrier.

Comparison of drug release behavior of bacterial cellulose loaded with ibuprofen and propranolol hydrochloride.

The aim of this study was to investigate the drug release behavior from bacterial cellulose (BC). Ibuprofen and propranolol hydrochloride were used as model drugs to represent low and highly water soluble drugs. The drug was loaded into the BC by immersing the partially swollen BC in a solution of drug concentrations ranging from 0.

Preparation and physicochemical characterization of sildenafil cocrystals.

Sildenafil is a specific inhibitor of the phosphodiesterase type 5 (PDE-5) enzyme that protects cyclic guanosine monophosphate from breakdown by PDE-5. It is a biopharmaceutical categorization system Class II medication with low bioavailability because it is almost insoluble in water. The objectives of this study were to prepare sildenafil cocrystals with co-former molecules including aspirin (acetylsalicylic acid [ASA]), fumaric acid (FMA), and benzoic acid (BZA) to improve the water solubility of sildenafil.