Publications by authors named "Pin-Hsuan Chiu"
Simplified computed tomography pulmonary angiography score predicts clinical deterioration in patients with acute pulmonary embolism.
Int J Cardiol Heart Vasc
August 2025
Background: Currently, simplified methods based on computed tomography pulmonary angiography (CTPA) to predict clinical deterioration in patients with acute pulmonary embolism (PE) are lacking. We developed a simplified imaging model with good clinical accessibility to predict this outcome.
Study Design And Methods: Patients with acute pulmonary embolism from 2008 to 2019 were retrospectively enrolled from two medical centers to form a study cohort and a validation cohort.
Article Synopsis
- Atrial fibrillation (AF) and premature atrial complexes (PACs) are linked to kidney function decline, but the specific effects of high PAC burden on renal outcomes were not previously studied.
- A study of 10,981 patients analyzed their Holter monitoring records to determine the relationship between PACs and adverse kidney events, categorizing patients into high, low PAC burden, and AF groups.
- Results showed that those with a high PAC burden had a 1.24-fold higher risk of major kidney events compared to the low PAC group, indicating that high PAC burden poses a risk similar to that of AF.
Background: The association between human epidermal growth factor receptor-2 (HER2) amplification and brain metastasis (BM) in patients having colorectal cancer (CRC) has been suggested but not yet established. This study investigated the expression patterns of HER2, its association with BM, and its prognostic value in patients having CRC.
Methods: We retrospectively identified 99 patients having metastatic CRC (mCRC) and BM (the BM cohort) and compared them with a cohort of 249 patients having mCRC and without BM (the stage IV cohort) by propensity score matching.
Repurposing nitric oxide donating drugs in cancer therapy through immune modulation.
J Exp Clin Cancer Res
January 2023
Background: Nitric oxide-releasing drugs are used for cardiovascular diseases; however, their effects on the tumor immune microenvironment are less clear. Therefore, this study explored the impact of nitric oxide donors on tumor progression in immune-competent mice.
Methods: The effects of three different nitric oxide-releasing compounds (SNAP, SNP, and ISMN) on tumor growth were studied in tumor-bearing mouse models.
Background: Obesity increases surgical risks in various abdominal surgeries and its impact on open pancreaticoduodenectomy (OPD) and minimally invasive pancreaticoduodenectomy (MIPD) remains unknown. This study aimed to compare the surgical outcomes of OPD and MIPD in obese and non-obese patients by propensity score matching (PSM) analysis during the implementation of MIPD.
Methods: We retrospectively reviewed all pancreaticoduodenectomies from December 2014 to May 2021.
The Beneficial Effects of Beta Blockers on the Long-Term Prognosis of Patients With Premature Atrial Complexes.
Front Cardiovasc Med
February 2022
Article Synopsis
- The study investigates the effects of beta blockers on long-term outcomes in patients with premature atrial complexes (PACs), focusing on their impact on mortality rates.
- In high-burden patients (≥100 PACs/24 h), beta blockers significantly reduced mortality compared to no treatment, but they did not affect the rates of new strokes or atrial fibrillation.
- Similarly, in low-burden patients (<100 PACs/24 h), there was a 40% risk reduction in mortality with beta blocker treatment, while there were no differences in stroke or atrial fibrillation occurrences, indicating a need for further investigation into these findings.
Hospice delivery models and survival differences in the terminally ill: a large cohort study.
BMJ Support Palliat Care
December 2021
Objective: A common difficulty at the end of life (EOL) is to determine an appropriate service model, such as hospice share care (HSC), hospice inpatient care (HIC) and hospice home care (HHC). This study aimed to recommend the appropriate hospice delivery model based on the physical, psychosocial and spiritual needs of patients referred for hospice care.
Methods: This cohort study included patients who received only one kind of hospice delivery model between 2006 and 2020.