Experiential reflex epilepsy demonstrated with stereoEEG.

Purpose: Reflex epilepsies are epileptic disorders in which seizures are consistently provoked by specific, identifiable stimuli-typically sensory or cognitive. In patients with memory-induced seizures, it has long been debated whether the memory acts as the trigger for the seizure or represents its first clinical manifestation.

Methods: We present the case of a 25-year-old woman with reflex seizures triggered by the recollection of specific autobiographical memories.

Lung and abdominal ultrasound accuracy for tuberculosis: An Indian prospective cohort study.

Background: Tuberculosis (TB) diagnosis remains a challenge, particularly in low-resource settings. Point-of-care ultrasound (POCUS) has shown promise, but most studies focus on HIV-infected populations. In the case of TB, data on lung ultrasound (LUS) are sparse.

Nanoscale Infrared and Microwave Imaging of Stacking Faults in Multilayer Graphene.

Graphite exhibits a range of metastable stacking orders, with the number of possible configurations increasing exponentially with the number of layers. Most experimental studies have focused on Bernal and rhombohedral stacking due to the difficulty of identifying and isolating intermediate stacking orders. Motivated by this challenge, we present two atomic force microscopy (AFM) techniques that unambiguously distinguish stacking orders and defects in graphite flakes.

Design and Benchmarking of a Two Degree of Freedom Tendon Driver Unit for Cable-Driven Wearable Technologies.

Exosuits have recently been developed as alternatives to rigid exoskeletons and are increasingly adopted for both upper and lower limb therapy and assistance in clinical and home environments. Many cable-driven exosuits have been developed but little has been published on their electromechanical designs and performance. Therefore, this paper presents a comprehensive design and performance analysis of a two degree of freedom tendon driver unit (TDU) for cable-driven wearable exosuits.

Accuracy of Imus and Monocular Human Pose Estimation at Measuring Elbow Flexion.

Markerless human pose estimation and inertial measurement units are two common methods for human movement analysis. They are cost-effective and easy to use, but their accuracy compared to established optical motion capture methods is yet to be determined for some movements. This study compared the accuracy of IMUs and BlazePose, a markerless monocular 3D human pose estimator, against a marker-based optical system for measuring elbow flexion angles.

Predictors of treatment survival in patients with plaque psoriasis treated with phototherapy: registry analysis.

Background: Little is known about treatment survival in patients with plaque psoriasis who have received phototherapy.

Objectives: to analyse treatment survival in patients with plaque psoriasis who had received photother-apy, irrespective of the number of sessions and type of phototherapy, and to identify factors that influence the risk of treatment discontinuation.

Methods: Data from the Psoriasis Registry Austria and the phototherapy registry of the Centre of Phototherapy at the Department of Dermatology and Venereology, Medical University of Graz, were retrospectively analysed using Kaplan-Meier curves (logrank test) and a Cox (proportional hazards) regression analysis, irrespective of the number of phototherapy sessions or type of phototherapy.

Mast cells express IL17A, IL17F and RORC in lesional psoriatic skin, are activated before therapy and persist in high numbers in a resting state with IL-17A positivity after treatment.

Background: The proinflammatory cytokine IL-17 is known to play an important role in psoriasis pathogenesis, but little is known about its regulation in psoriasis or after treatment.

Objective: Aiming to investigate the role of IL-17 regulation in the resolution of psoriasis, we analyzed biopsy samples from patients with plaque psoriasis, including non-lesional and lesional skin at baseline and after anti-IL-17 and -IL-23 antibody, topical dithranol or UVB treatment as well as skin from healthy donors.

Methods: Skin biopsy samples were analyzed using immunostaining, RNA sequencing and in situ mRNA detection.

Cardiomyopathy in patients with acromegaly - not truly a concern anymore?

Acromegaly is associated with increased mortality rates if not adequately treated. Cardiovascular and metabolic comorbidities are highly prevalent and have long been considered the main cause of death among patients with acromegaly. However, substantial advances in GH/IGF-I-lowering treatment, together with increased awareness and optimized management of other risk factors, have led to major improvements in mortality rates in the 2-3 past decades.

High-Resolution Spatial Map of the Human Facial Sebaceous Gland Reveals Marker Genes and Decodes Sebocyte Differentiation.

The sebaceous gland (SG) is essential for skin homeostasis by producing sebum to lubricate and protect the skin. Dysfunctions in SG activity are associated with skin disorders such as acne, seborrheic dermatitis, and alopecia. However, its cellular and molecular mechanisms in humans remain poorly understood because most studies have been conducted in mouse models.

Associations of Thyroid and Parathyroid Hormones with Arterial Stiffness in Emergency Department Patients: A Prospective Cross-Sectional Study.

Cardiovascular diseases are prevalent entities, especially in emergency patients. Arterial stiffness is a known predictor of cardiovascular risk and mortality and is quantified by carotid-femoral pulse wave velocity (cfPWV). It is caused in part by vascular calcification, but exact details of the underlying mechanisms are yet to be elucidated, and current data suggest endocrine influences.

Urocanase-Positive Skin-Resident Bacteria Metabolize cis-Urocanic Acid and in Turn Reduce the Immunosuppressive Properties of UVR.

The skin microbiome plays an important role in health and disease. We have recently shown that microbes living on the skin regulate the immunomodulatory properties of UVR, but the underlying mechanisms remain to be uncovered. Using a preclinical model of immunosuppression against the chemical allergen 2,4-dinitrofluorobenzene, 16S microbiome sequencing, in vitro cultures, high-performance liquid chromatography-mass spectrometry and the generation of gnotobiotic-like mice, we report that acute UVB radiation induces a transient and significant restructuring of bacterial communities on the skin through one of its major photoproducts, cis-urocanic acid.

Force Volume Atomic Force Microscopy-Infrared for Simultaneous Nanoscale Chemical and Mechanical Spectromicroscopy.

Photothermal atomic force microscopy-infrared (AFM-IR) combines the nanoscale spatial resolution of AFM with the chemical identification capability of infrared spectroscopy and has thrived in various applications. Currently executed in three major AFM modes (contact, tapping, and peak force tapping) we introduce a fourth variant built upon force volume mode comprising a defined engage, hold, and retract segment in each pixel. IR laser pulsing at a probe resonance frequency during the constant-force hold segment duplicates the resonance-enhanced AFM-IR detection principle of contact mode.

Phototherapy of granuloma annulare: a single center retrospective study.

Background: Granuloma annulare is a chronic, benign skin condition characterized by small erythematous patches, plaques or papules in annular or disseminated order. Due to the cosmetic impact, many patients experience a significant level of distress. Nevertheless, selecting the optimal treatment method often poses a challenge due to the limited available data.

Metabolomic and Lipidomic Alterations in Patients with Atopic Dermatitis with Dupilumab-Associated Ocular Surface Disease.

Atopic dermatitis (AD) is an inflammatory skin disease characterized by chronic pruritic eczema with an estimated prevalence of 10% in adults and 50% of them suffering from moderate-to-severe manifestations. Dupilumab, an IL-4/IL-13 inhibitor, is approved for treating moderate-to-severe AD. However, dupilumab-associated ocular surface disease (DAOSD) emerges in up to 60% of dupilumab-treated patients, constituting a major AD-specific adverse event.

Health Status and Patients' Satisfaction on the Long Term after Metabolic/Bariatric Surgery.

Introduction: Bone fractures and vitamin deficiencies are potential long-term risks after metabolic/bariatric surgery (MBS). This study aimed to evaluate the health status of patients with an average follow-up of 15 years after MBS, focusing on vitamin deficiencies, patients' satisfaction, and bone fractures.

Methods: A questionnaire-based cross-sectional study was performed.

Burden to Partners of People with Psoriasis: Results from the FamilyPso International Study.

Background: Psoriatic disease is a lifelong chronic illness for which there is no cure. It is well established that psoriasis leads to a major impairment of health-related quality-of-life and wellbeing. Most people with psoriasis live together with partners, bringing along a major burden for them.

Growth Hormone Promotes Hepatic Triglyceride Export in Humans.

Context: Growth hormone (GH) reduces intrahepatic lipids (IHL) according to investigations in healthy volunteers and patients with acromegaly, a disease characterized by long-term GH excess.

Objective: This study investigated underlying antisteatotic pathways stimulated by short-term modulation of GH action.

Methods: Ten healthy male volunteers (26 ± 5 years, body mass index [BMI] 23 ± 3.

Leptin acutely increases hepatic triglyceride secretion in patients with lipodystrophy.

Background And Aims: Metreleptin ameliorates hepatic steatosis partially independent of its anorexic action. We previously showed that metreleptin increases hepatic very low-density lipoprotein triglycerides (VLDL1-TG) export in rodents and healthy humans requiring intact hepatic autonomic innervation. The primary aim of this study was to investigate whether metreleptin has anti-steatotic properties in patients with lipodystrophy by increasing VLDL1-TG export.

Chemical Mapping of Supramolecular Self-Assembled Monolayers via Atomic Force Microscopy-Based Infrared with a Nanometer-Scale Lateral Resolution.

Atomic force microscopy-based infrared (AFM-IR) techniques have long enabled chemical imaging of surfaces with spatial resolutions down to 10 nm. In this study, we push the boundaries of AFM-IR spatial resolution to the single-nanometer scale, achieving chemical mapping of supramolecular networks at the submolecular level. This breakthrough is made possible by implementing an innovative tapping-mode AFM-IR approach.

The molecular circadian clock of eosinophils: a potential therapeutic target for asthma.

Asthma is a chronic inflammatory airway disease exhibiting time-of-day variability in symptoms and severity. Eosinophils, pivotal players and biomarkers in asthma, are regulated by the molecular circadian clock. This study aimed to investigate the impact of the molecular circadian clock on eosinophil effector function and its potential as a diagnostic biomarker and therapeutic target.

Evidence of immunogenic cell death (ICD) and ICD-dependent dendritic cell activation induced by extracorporeal photopheresis in patients with leukaemic forms of cutaneous T-cell lymphoma.

Background: Despite novel therapeutic options, the long-term management of cutaneous T-cell lymphoma (CTCL) remains challenging. Extracorporeal photopheresis (ECP) is an immunomodulating photochemotherapy associated with higher overall survival when used for the treatment of leukaemic forms of CTCL. Its exact mode of action has not been fully elucidated.

Changes in Kinematic and Spatiotemporal Gait Parameters With a Biarticular Lower Limb Exosuit for Adolescents With Crouch Gait During Level Walking and Stair Climbing.

Crouch gait is a prevalent walking abnormality among children with cerebral palsy, characterized by excessive knee and hip flexion during walking. This condition often limits children's engagement in physical activities and daily life. Current exoskeleton solutions targeting the knee joint in this population are either tethered or bulky, hindering practical integration into daily routines.

IL-36-driven pustulosis: Transcriptomic signatures match between generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP).

Background: Due to similarities, the distinction between generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis (AGEP) has been a matter of debate for a long time.

Objectives: Our aim was to define the molecular features of GPP and AGEP.

Methods: We analyzed skin biopsy samples and clinical data from 125 patients with AGEP, GPP, palmoplantar pustulosis (PPP), plaque psoriasis (PSO), and nonpustular cutaneous adverse drug reactions (ADRs), as well as from healthy skin controls using RNA-sequencing and blinded histopathologic analyses.