Publications by authors named "Paul D Kastner"
Article Synopsis
- Salt sensitivity of blood pressure (SSBP) is a significant risk factor for cardiovascular disease, influenced by sodium intake and is associated with changes in antigen-presenting cells (APCs) and the JAK2 signaling pathway.
- The study utilized various methods, including transcriptomic analyses, mouse models, and immunophenotyping, to investigate the effects of high salt on blood pressure and the underlying mechanisms involving JAK2, STAT3, and SMAD3.
- Results showed that high salt increases the expression of genes in the JAK/STAT/SMAD pathway in human monocytes, and the knockout of JAK2 in APCs significantly reduced salt-induced hypertension in mice, indicating a crucial role of this pathway in S
In temperate marine climate zones, seasonal changes in water temperature contribute to distinct populations of warm- and cold-water vibrios. We report here the complete genome sequence (BUSCO score=94.8) of the novel strain sp.
View Article and Find Full Text PDFPostural orthostatic tachycardia syndrome (POTS) is a devastating chronic form of orthostatic intolerance associated with excessive heart rate increase without hypotension during upright posture. POTS patients exhibit increased circulating norepinephrine levels with exaggerated sympathetic nervous system response upon standing. Emerging evidence suggests a role for the gut microbiome in cardiovascular disorders.
View Article and Find Full Text PDFDraft Genome Sequence of Psychrotolerant sp. Strain VB17, Isolated from Marine Intertidal Sediment near Virginia Beach, Virginia.
Microbiol Resour Announc
November 2020
We present the draft genome sequence of sp. strain VB17, which was isolated from Virginia Beach, Virginia, intertidal sediment. The 5.
View Article and Find Full Text PDF