Publications by authors named "Pascal Maas"
Analyzing metabolites using mass spectrometry provides valuable insight into an individual's health or disease status. However, various sources of experimental variation can be introduced during sample handling, preparation, and measurement, which can negatively affect the data. Quality assurance and quality control practices are essential to ensuring accurate and reproducible metabolomics data.
View Article and Find Full Text PDFArticle Synopsis
- Metabolomics using HILIC-MS is effective for identifying polar metabolites and aiding in biomarker discovery, but matrix effects can complicate biological analysis.
- Evaluation of matrix effects is critical in method development, and this study tested two techniques: stable isotope labeled-internal standards and post-column infusion (PCI).
- Results indicated that the PCI method is more advantageous for untargeted analysis, showing better performance in assessing matrix effects and highlighting significant ion suppression in various plasma samples.
Immunometabolism, which concerns the interplay between metabolism and the immune system, is increasingly recognized as a potential source of novel drug targets and biomarkers. In this context, the use of metabolomics to identify metabolic characteristics associated with specific functional immune response processes is of value. Currently, there is a lack of tools to determine known associations between metabolites and immune processes.
View Article and Find Full Text PDF