Novel Grm6 Variant in a no b-wave (nob) Mouse Model: Phenotype Characterization and Gene Therapy.

Purpose: To characterize a no b-wave (nob) mouse model of congenital stationary night blindness (CSNB) caused by a Grm6 variant that disrupts photoreceptor-to-bipolar cell signaling. Additionally, we aim to evaluate the efficacy of gene therapy in restoring visual function.

Methods: The nob mouse was generated through selective breeding to regenerate the nob phenotype.

Engineered microbial production of carotenoids and their cleavage products: Recent advances and prospects.

Carotenoids and their cleavage products (referred to as apocarotenoids) have functional properties such as antioxidant activity, fragrance, and color that are important in the pharmaceutical, healthcare, cosmetics, and food industries. Currently, carotenoids and apocarotenoids are primarily obtained through extraction from natural sources or chemical synthesis, both of which are associated with inefficiencies, environmental impact, and product limitations. Ongoing advances in metabolic engineering and synthetic biology have positioned heterologous biosynthesis as a promising, efficient, and sustainable production strategy.

Metabolic benefits conferred by duplication of the facilitated trehalose transporter in Lepidoptera.

In addition to being one of the primary processes for the formation and expansion of gene families, gene duplication also establishes the basis for the diversity and redundancy of gene functions, providing an abundance of genetic resources and a potent adaptive potential for biological evolution. Trehalose is a high-quality carbon source and blood sugar in insects. However, recent theoretical developments suggest that mechanisms for facilitated trehalose transport in lepidopteran insects remain relatively scarce.

Comparison of clinical manifestations, antimicrobial susceptibility patterns, and carbapenem resistance determinants between Acinetobacter seifertii and Acinetobacter nosocomialis isolated in Taiwan.

Background: Acinetobacter seifertii, a recently identified member of the Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex, has emerged as a cause of severe human infections. It is closely related to Acinetobacter nosocomialis, a major pathogen of the Acb complex. Here, we aimed to explore the clinical and molecular differences between these two species.