Is there really a relationship between maxillary and mandibular incisor inclination and the amount of surrounding cortical alveolar bone? a systematic review.

Background: For orthodontists, the position of the incisors is a key factor in setting treatment goals. Achieving maximum stability requires that they be positioned in the medullary portion of the alveolar bone, balanced with the lingual and labial musculature. Incorrect orthodontic movements can result in root resorption, dehiscences, or even fenestrations.

Model robust designs for dose-response models.

An optimal experimental design is a structured data collection plan aimed at maximizing the amount of information gathered. Determining an optimal experimental design, however, relies on the assumption that a predetermined model structure, relating the response and covariates, is known a priori. In practical scenarios, such as dose-response modeling, the form of the model representing the "true" relationship is frequently unknown, although there exists a finite set or pool of potential alternative models.

Risk prediction for hemodialysis initiation: The role of Kidney Failure Risk Equation and personalized timely vascular access referral.

Introduction: Optimal timing for arteriovenous fistula creation in chronic kidney disease is challenging. Late referral results in hemodialysis (HD) initiation via a central venous catheter (CVC), whereas early referral may lead to unnecessary procedures. We evaluate the predictive value of estimated glomerular filtration rate (eGFR) and the 2-Year Kidney Failure Risk Equation (KFRE) in forecasting HD initiation.

Dietary psychoactive xenobiotics: an updated review on food contamination with ergot, tropane and opium alkaloids and their toxicological effects.

Food contamination has been a major health issue since the beginning of human existence. Some food contaminants trigger important psychological manifestations, such as delirium, hallucinations, and psychosis, which may cause distress, aggravate pre-existing conditions, and dangerously interact with certain medications. Exposure to psychoactive food contaminants can ultimately lead to severe health problems or even death.

Protective Role of the Natural Antioxidant Astaxanthin in Both Human Bronchial Epithelial Cells (BEAS-2B) and Non-Small Cell Lung Cancer Cells (H1975) Exposed to Cadmium: Impact on the Generation of Reactive Oxygen Species and Cancer Cell Migration.

Cadmium (Cd) is a heavy metal and human carcinogen that displays toxicity to many organ systems. This work addresses the impact of Cd, alone or combined with astaxanthin (ATX), in human non-small cell lung cancer (NSCLC) cells (H1975) and nonmalignant bronchial epithelial cells (BEAS-2B). The endpoints selected comprise cell viability, migration, generation of reactive oxygen species (ROS), and a metabolomic study.

When Sardines Disappear: Tracking Common Dolphin, , Distribution Responses Along the Western Iberian Coast.

The common dolphin, , is the most abundant cetacean species along the western Iberian Peninsula and faces many anthropogenic threats, with bycatch being the most impactful. Its preferred prey, sardine (), has shown fluctuating abundance over the past decade, potentially influencing dolphin distribution. This study provides the first insights into common dolphin distribution along the western Iberian coast, using sighting data from vessel research surveys (2005-2020) to identify hotspot areas while accounting for monthly and seasonal distributions overlapping with sardine abundance.

Risk factors for failure in short segment pedicle instrumentation in thoracolumbar fractures.

Introduction: The management of thoracolumbar fractures, particularly through short-segment posterior fixation (SSPF), remains a topic of ongoing debate in spine surgery.

Research Question: This study aimed to identify the factors influencing SSPF failure in traumatic thoracolumbar fractures' treatment, focusing on variables such as age, bone mineral density (BMD), fracture level, posterior ligamentous complex (PLC) injury, screw length, type of screw (monoaxial or polyaxial), instrumentation of the fractured vertebra and sagittal screw angle (SSA).

Material And Methods: A total of 66 patients were included, with 43 in the non-failure group (Group N) and 23 in the failure group (Group F).

The Role of Covered Stents in Hemodialysis Access: Experience From a Vascular Access Centre.

Background Vascular access (VA) dysfunction in hemodialysis (HD) significantly impacts patient outcomes. While percutaneous transluminal angioplasty remains the primary intervention, covered stents (CSs) have emerged as a valuable adjunct. This study evaluates the efficacy of CS in reducing reinterventions and delaying subsequent procedures.

Assessing oral and dental health-related quality of life in head and neck cancer patients at 1, 5, and 10 years: a comparison of the EORTC QLQ43, FACT H&N, and the Orthognathic-QLQ questionnaires.

Purpose: Numerous health-related quality of life (HRQoL) questionnaires are available to assess oral HRQoL in patients undergoing treatment for head and neck (H&N) cancer. These multidimensional instruments should have the capacity to detect meaningful clinical oral function/dental changes at different time points. However, the optimal instrument-or combination of instruments-for assessing oral health and dental needs is not clear.

Endovascular Thrombectomy of Arteriovenous Dialysis Access: A Feasible Treatment?

Introduction: There is no single best treatment for arteriovenous vascular access thrombosis, with comparable patency rates for both surgical and endovascular treatment. This study aims to evaluate the results of endovascular thrombectomy in our center and analyze the patency rates in different groups.

Material And Methods: We retrospectively selected patients referred to our vascular access treatment unit due to arteriovenous access thrombosis from June 2017 to February 2022.

Toward Accurate pH-Dependent Binding Constant Predictions Using Molecular Docking and Constant-pH MD Calculations.

pH is an important physicochemical property that modulates proteins' structure and interaction patterns. A simple change in a site's protonation state in an enzyme's catalytic pocket can strongly alter its activity and its affinity to substrate, products, or inhibitors. We addressed this pH effect issue by evaluating its impact on donepezil binding to acetylcholinesterase (AChE).

Thoracolumbar fractures: Factors predicting failure of percutaneous short- and long-segment posterior fixation.

Introduction: Thoracolumbar (TL) transition trauma is frequent and challenging. Although short- (SSPF) and long-segment posterior fixation (LSPF) are its mainstay treatment, little is known about their failure rates and reasons behind it.

Research Question: understand why TL instrumentations fail and what factors influence it.

The Accuracy of Algorithms Used by Artificial Intelligence in Cephalometric Points Detection: A Systematic Review.

The use of artificial intelligence in orthodontics is emerging as a tool for localizing cephalometric points in two-dimensional X-rays. AI systems are being evaluated for their accuracy and efficiency compared to conventional methods performed by professionals. The main objective of this study is to identify the artificial intelligence algorithms that yield the best results for cephalometric landmark localization, along with their learning system.

Isolated Cricoid Fracture After Intubation.

Isolated cricoid fractures are exceedingly rare but can be life-threatening. Injuries caused by minor neck trauma related to external laryngeal manipulation or an inappropriate tube cuff size have been reported in the literature. Symptoms typically appear immediately after the traumatic episode.

Benign Yellow Dot Maculopathy: A Case Series of Patients With a Recently Discovered Macular Phenotype.

Benign yellow dot maculopathy (BYDM) is a recently described rare, asymptomatic, early onset, and non-progressive macular phenotype. It is characterized by the presence of multiple white-yellow dots encircling the fovea, which are hyperautofluorescent on fundus autofluorescence. Here, we expand on the few reports available by presenting a case series of five Portuguese patients with clinical BYDM phenotype and congruent multimodal imaging, including the second reported unilateral case.

Novel DNA Repair Inhibitors Targeting XPG to Enhance Cisplatin Therapy in Non-Small Cell Lung Cancer: Insights from In Silico and Cell-Based Studies.

NSCLC is marked by low survival and resistance to platinum-based chemotherapy. The XPG endonuclease has emerged as a promising biomarker for predicting the prognosis of cisplatin-treated patients and its downregulation having been reported to increase cisplatin efficacy. This study presents an integrated strategy for identifying small molecule inhibitors of XPG to improve cisplatin therapy in NSCLC.

Inflammation and Vasculitis Related to Brolucizumab.

: To compare the prevalence of intra-ocular inflammation (IOI) between brolucizumab and aflibercept in neovascular age-related macular degeneration (nAMD) after intra-vitreal injections (IVI) and to compare the IOI odds ratios (ORs) of both therapies with the prevalence of septic endophthalmitis after IVI that was previously reported in the literature. : A total of 468 IVI of brolucizumab (117 eyes) were compared with 2884 IVI of aflibercept (305 eyes) regarding IOI and occlusive retinal vasculitis (RV) from December 2021 to June 2023 in this retrospective study. The OR was calculated for both anti-VEGF agents and was compared with the relative risk of septic endophthalmitis after IVI.

Constant-pH MD simulations of the protonation-triggered conformational switching in diphtheria toxin translocation domain.

Protonation of key residues in the diphtheria toxin translocation (T)-domain triggered by endosomal acidification is critical for inducing a series of conformational transitions critical for the cellular entry of the toxin. Previous experiments revealed the importance of histidine residues in modulating pH-dependent transitions. They suggested the presence of a "safety latch" preventing premature refolding of the T-domain by a yet poorly understood mechanism.

A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound.

The therapeutic approach to many solid tumors, including non-small cell lung cancer (NSCLC), is mainly based on the use of platinum-containing anticancer agents and is often characterized by acquired or intrinsic resistance to the drug. Therefore, the search for safer and more effective drugs is still an open challenge. Two organometallic ruthenium(II)-cyclopentadienyl compounds [Ru(η-CHCHO)(Mebipy)(PPh)] (RT150) and [Ru(η-CHCHOH)(Mebipy)(PPh)][CFSO] (RT151) were tested against a panel of cisplatin-resistant NSCLC cell lines and xenografts.

Inter-observational analysis of computed tomography parameters to predict nonobvious posterior ligament complex injury in neurologically intact patients with thoracolumbar trauma.

Introduction: Assessing the integrity of the posterior ligament complex (PLC), as a key element in the characterization of an unstable Thoracolumbar fracture (TLF), is challenging, but crucial in the choice of treatment.

Research Question: How to create a reproducible score using combined parameters of Computed Tomography (CT) to predict nonobvious PLC injury. How CT parameters relate with PLC status.

Improving the Quality of Life of a Kidney Transplant Patient With Limb Edema: Amplatzer Vascular Plug Embolization of an Arteriovenous Fistula.

An arteriovenous fistula is the preferred vascular access option for hemodialysis patients. However, complications, such as high-output heart failure and upper limb edema due to central vein stenosis, may arise.  We describe a case of a 65-year-old kidney transplant patient with severe edema in the left arm due to central vein stenosis and ipsilateral umerocephalic arteriovenous fistula.

Impact of the redox-active MnTnHex-2-PyP and cisplatin on the metabolome of non-small cell lung cancer cells.

Redox-based cancer therapeutic strategies aim to raise reactive oxygen species (ROS) levels in cancer cells, thus modifying their redox status, and eventually inducing cell death. Promising compounds, known as superoxide dismutase mimics (SODm), e.g.

The EORTC QLQ43 and FACT H&N questionnaires of quality of life at 1 and 5 years after treatment and dental care in head and neck cancer patients: a pilot study.

Purpose: This study aimed to examine health-related quality of life (HRQoL) in head and neck cancer patients at 1 and 5 years after successful treatment of their tumors, and to explore the usefulness of 2 instruments for assessing the need of dental care services.

Methods: This cross-sectional pilot study included 20 adult patients with head and neck cancer who completed the Functional Assessment of Cancer Therapy-Head and Neck (FACT H&N) Symptom Index and the European Organization for Research and Treatment of Cancer Quality of Life Head and Neck Module (EORTC QLQ-H&N43) after 1 and 5 years of treatment.

Results: Mean (standard deviation, SD) scores of the FACT H&N Symptom Index were higher (better HRQoL) at 5 years than at 1 year (24.