From Plants to Patients: Advancing Cancer Therapy With Bioengineered Exosomes and AI-Driven Innovations.

Cancer is a leading global cause of death, with complex pathogenesis and treatment challenges like poor selectivity, toxicity, and drug resistance. Nanotechnology offers transformative solutions, with plant-derived exosomes (EXOs) emerging as promising green nanomaterials for personalized cancer therapy because of their biocompatibility and minimal antigenicity, and eco-friendly production. This review discusses the potential of plant EXOs in cancer treatment, covering isolation methods, advantages over mammalian EXOs (e.

Urine-derived stem cells: a sustainable resource for advancing personalized medicine and dental regeneration.

Urine-based therapy, an ancient practice, has been utilized across numerous civilizations to address a wide range of ailments. Urine was considered a priceless resource in numerous traditional therapeutic applications due to its reported medicinal capabilities. While the utilization of urine treatment is contentious and lacks significant support from modern healthcare, the discovery of urine-derived stem cells (UDSCs) has introduced a promising avenue for cell-based therapy.

Revolutionizing Dental Polymers: The Versatility and Future Potential of Polyetheretherketone in Restorative Dentistry.

Polyetheretherketone (PEEK) has emerged as a revolutionary material in modern dentistry because of its unique combination of mechanical strength, biocompatibility, and versatility. This literature review examines the current applications and future potential of PEEK in various dental disciplines. PEEK's favorable properties, including its low specific weight, high strength-to-weight ratio, and ability to be easily machined, have led to its adoption in prosthetics, implantology, and dental esthetic restorations.

Performance of the ChatGPT-3.5, ChatGPT-4, and Google Gemini large language models in responding to dental implantology inquiries.

Statement Of Problem: Artificial intelligence (AI) chatbots have been proposed as promising resources for oral health information. However, the quality and readability of existing online health-related information is often inconsistent and challenging.

Purpose: This study aimed to compare the reliability and usefulness of dental implantology-related information provided by the ChatGPT-3.

Effect of coffee roasting level on tooth discoloration.

Purpose: Coffee consumption is a well-known contributor to tooth discoloration, and the extent of staining is influenced by the chemical composition of the coffee. This study investigated the associations of coffee roasting level, chlorogenic acid (CGA) content, absorbance level, and their combined effects with tooth discoloration.

Methods: Bovine tooth enamel specimens were immersed in light, medium, and dark roasts of four coffee types (two Arabica and two Robusta coffees) for 72 h.

Prospective and challenges of locally applied repurposed pharmaceuticals for periodontal tissue regeneration.

Periodontitis is a persistent inflammatory condition that causes periodontal ligament degradation, periodontal pocket development, and alveolar bone destruction, all of which lead to the breakdown of the teeth's supporting system. Periodontitis is triggered by the accumulation of various microflora (especially anaerobes) in the pockets, which release toxic substances and digestive enzymes and stimulate the immune system. Periodontitis can be efficiently treated using a variety of techniques, both regional and systemic.

Accuracy of repaired maxillary dentures from two different repairing techniques: In vitro study.

Background: Denture fracture is a common problem with acrylic dentures. The fractured denture can be repaired using various techniques such as self-cure acrylic resin acrylic resin and fiber-reinforced acrylic resin.

Purpose: The purpose of this study was to compare the accuracy of dentures repaired with self-cure acrylic resin and fiber-reinforced acrylic resin processed using two different techniques (long-cure and microwave processing).

Challenges of therapeutic applications and regenerative capacities of urine based stem cells in oral, and maxillofacial reconstruction.

Urine-derived stem cells (USCs) have gained the attention of researchers in the biomedical field in the past few years . Regarding the several varieties of cells that have been used for this purpose, USCs have demonstrated mesenchymal stem cell-like properties, such as differentiation and immunomodulation. Furthermore, they could be differentiated into several lineages.

Bioactive injectable mucoadhesive thermosensitive natural polymeric hydrogels for oral bone and periodontal regeneration.

Periodontitis is an inflammation-related condition, caused by an infectious microbiome and host defense that causes damage to periodontium. The natural processes of the mouth, like saliva production and eating, significantly diminish therapeutic medication residency in the region of periodontal disease. Furthermore, the complexity and diversity of pathological mechanisms make successful periodontitis treatment challenging.

Prospectives and challenges of nano-tailored biomaterials-assisted biological molecules delivery for tissue engineering purposes.

Nano carriers have gained more attention for their possible medical and technological applications. Tailored nanomaterials can transport medications efficiently to targeted areas and allow for sustained medication discharge, reducing undesirable toxicities while boosting curative effectiveness. Nonetheless, transitioning nanomedicines from experimental to therapeutic applications has proven difficult, so different pharmaceutical incorporation approaches in nano scaffolds are discussed.

Comparative analysis of dimensional changes in autoclavable polyvinyl siloxane (PVS) impressions under various Sterilization/Disinfection Protocols: A randomized controlled trial.

Background: Impressions that maintain their dimensional stability after autoclaving effectively control cross-infection and contamination resulting from a patient's oral secretions.

Purpose: The study aimed to assess the dimensional stability of autoclavable polyvinyl siloxanes after disinfection and sterilization.

Methods: A stainless steel metal model containing three full veneer crown preparations was fabricated according to ANSI/ADA specification No.

Comparative Evaluation of TiO Nanoparticle Addition and Postcuring Time on the Flexural Properties and Hardness of Additively Fabricated Denture Base Resins.

Three-dimensionally (3D)-printed fabricated denture bases have shown inferior strength to conventional and subtractively fabricated ones. Several factors could significantly improve the strength of 3D-printed denture base resin, including the addition of nanoparticles and post-curing factors. This study evaluated the effect of TiO nanoparticle (TNP) addition and the post-curing time (PCT) on the flexural properties and hardness of three-dimensionally (3D)-printed denture base resins.

The Effect of Coronal Pre-flaring and Type of Root Canal Irrigation on Working Length Accuracy Using Electronic Apex Locators.

Successful root canal treatment is influenced by the apical extent of root canal preparation and the eventual root canal filling. Achieving the full working length until the apical constriction, which is usually 0.5 - 1 mm shorter than the anatomical apex, is crucial.

The Toothbrushing Effects on Surface Properties and Color Stability of CAD/CAM and Pressable Ceramic Fixed Restorations-An In Vitro Study.

Pressable ceramic restorations have been introduced and investigated, and found comparable to CAD/CAM ceramic in terms of mechanical properties; however, the effect of toothbrushing on the pressable ceramic has not been thoroughly investigated. The objective of the current study was to assess the effect of artificial toothbrushing simulation on the surface roughness, microhardness, and color stability of different ceramic materials. Three lithium disilicate-based ceramics (IPS Emax CAD [EC], IPS Emax Press [EP]; (Ivoclar Vivadent AG), and LiSi Press [LP] (GC Corp, Tokyo, Japan)) were examined.

Improved Mechanical Properties and Bioactivity of Silicate Based Bioceramics Reinforced Poly(ether-ether-ketone) Nanocomposites for Prosthetic Dental Implantology.

Polyether-ether-ketone (PEEK) biomaterial has been increasingly employed for orthopedic, trauma, spinal, and dental implants due to its biocompatibility and in vivo stability. However, a lack of bioactivity and binding ability to natural bone tissue has significantly limited PEEK for many challenging dental implant applications. In this work, nanocomposites based on PEEK reinforced with bioactive silicate-based bioceramics (forsterite or bioglass) as nanofillers were prepared using high energy ball milling followed by melt blending and compression molding.

Push-Out Bond Strength of EndoSeal Mineral Trioxide Aggregate and AH Plus Sealers after Using Three Different Irrigation Protocols.

Objective:  The current study was designed to assess the bonding strength of EndoSeal MTA and AH Plus sealers after using three irrigation protocols as follows: (1) 17% Ethylenediamine tetraacetic acid, (2) 7% maleic acid, and (3) 37% phosphoric acid.

Materials And Methods:  Push-out bond strength was evaluated for 60 middle root slices of 1-mm thickness each. They were horizontally cut from freshly extracted single-rooted human teeth.