Implementation and validation of a channelized hotelling observer model (CHO) in an AIFM task group: a national multicentric study in x-ray angiography (XA), a comprehensive and wide-reaching approach.

This study aims to prove the feasibility of objectively characterizing clinical XA protocols by implementing a model observer. The model observer's performance aligns with a human observer's and is described using a simple and comprehensive figure of merit (FOM). The practical implications of this study, which utilized the Leeds TO10 phantom to acquire 146 imaging datasets in a fixed setup measuring kerma rate from four manufacturers and seven XA models by thirteen hospitals, are significant.

Safety injections of nuclear medicine radiotracers: towards a new modality for a real-time detection of extravasation events and F-FDG SUV data correction.

Background: F-FDG PET/CT imaging allows to study oncological patients and their relative diagnosis through the standardised uptake value (SUV) evaluation. During radiopharmaceutical injection, an extravasation event may occur, making the SUV value less accurate and possibly leading to severe tissue damage. The study aimed to propose a new technique to monitor and manage these events, to provide an early evaluation and correction to the estimated SUV value through a SUV correction coefficient.

Novel Harmonization Method for Multi-Centric Radiomic Studies in Non-Small Cell Lung Cancer.

The purpose of this multi-centric work was to investigate the relationship between radiomic features extracted from pre-treatment computed tomography (CT), positron emission tomography (PET) imaging, and clinical outcomes for stereotactic body radiation therapy (SBRT) in early-stage non-small cell lung cancer (NSCLC). One-hundred and seventeen patients who received SBRT for early-stage NSCLC were retrospectively identified from seven Italian centers. The tumor was identified on pre-treatment free-breathing CT and PET images, from which we extracted 3004 quantitative radiomic features.