Publications by authors named "Nitesh Kumar Pathak"

Serotonin is an important biogenic monoamine neurotransmitter that has major influences on mental health disorders; its structural and conformational changes have important roles in the biological functions of the human body. The decreased serotonin levels in the human body are majorly attributed to the causes of anxiety, depressive disorders, mood disorders, etc. Therefore, the quantification of serotonin in our bodies is of utmost importance in unearthing the origin of such physiological disorders.

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Two self-healing-type supramolecular Ni(II)-metallogels are achieved. The choice of proper low-molecular-weight organic gelators such as -butenedioic acid (, -BDA) and -butenedioic acid (, -BDA) and triethylamine in ,'-dimethylformamide solvent facilitates the metallogelation process. Through rheological investigations the mechanical robustness and viscoelastic properties of synthesized metallogels are explored.

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Indolamines (e.g., serotonin and melatonin) are tryptophan-derived class of neurotransmitters and neuromodulators that play crucial roles in mood regulation, sleep-wake cycles, and gastrointestinal functions.

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Hematin anhydride (β-hematin), the synthetic analogue of the malaria pigment, "hemozoin", is a heme dimer produced by reciprocal covalent bonds among carboxylic acid groups on the protoporphyrin-IX ring and the iron atom present in the two adjacent heme molecules. Hemozoin is a disposal product formed from the digestion of hemoglobin present in the red blood cells infected with hematophagous malaria parasites. Besides, as the parasites invade red blood cells, hemozoin crystals are eventually released into the bloodstream, where they accumulate over time in tissues.

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Article Synopsis
  • Dopamine plays a crucial role in motor function, motivation, addiction, and reward, and its imbalance can lead to various mental and neurological disorders like ADHD and schizophrenia.
  • Various techniques have been developed to detect dopamine, but recent research has focused on its natural ability to fluoresce under mid-ultraviolet light, allowing for real-time imaging in brain tissues.
  • The closed-aperture Z-scan method has uncovered dopamine's nonlinear photophysical properties, suggesting that factors like temperature and absorption influence its behavior, paving the way for future studies on how these properties relate to dopamine regulation and associated diseases.
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Norepinephrine (NE), a crucial modulatory neurotransmitter, plays a significant role in human physiology. Here, we use the Z-scan technique to investigate the nonlinear properties of NE at physiological conditions. Results reveal that NE exhibits thermo-optical nonlinearity.

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