Total synthesis and algaecidal activity of questiomycins against harmful bloom forming dinoflagellates.

We report the total synthesis of questiomycins A, C-E and analogues, and their algaecidal activity against three harmful bloom- and toxin-forming algae: , , and . Structure-activity relationship studies revealed potent derivatives with distinct modes of action, signalling their potential as targeted agents for harmful algal bloom control.

Metabolome Mining of L. Using HPLC-MS/MS and Molecular Networking.

Turmeric, L., is a type of medicinal plant characterized by its perennial nature and rhizomatous growth. It is a member of the Zingiberaceae family and is distributed across the world's tropical and subtropical climates, especially in South Asia.

Pattern of Deaths among Women of Reproductive Age in Major Autopsy Centres of Capital Cities of the Seven Provinces of Nepal.

Background: The females in the reproductive age group are vulnerable to injuries and diseases. There is no reliable evidence of the pattern of deaths in reproductive age group females from Nepal. This study was conducted to explore the patterns of deaths of females of the reproductive age group in Nepal.

Colossal Nernst power factor in topological semimetal NbSb.

Today solid-state cooling technologies below liquid nitrogen boiling temperature (77 K), crucial to quantum information technology and probing quantum state of matter, are greatly limited due to the lack of good thermoelectric and/or thermomagnetic materials. Here, we report the discovery of colossal Nernst power factor of 3800 × 10W m K under 5 T at 25 K and high Nernst figure-of-merit of 71 × 10K under 5 T at 20 K in topological semimetal NbSb single crystals. The observed high thermomagnetic performance is attributed to large Nernst thermopower and longitudinal electrical conductivity, and relatively low transverse thermal conductivity.

The Hydrophobin Gene Family Confers a Fitness Trade-off between Spore Dispersal and Host Colonization in Penicillium expansum.

Hydrophobins are small amphipathic surface proteins found exclusively in fungi. In filamentous ascomycetes, one conserved role of a subset of hydrophobins is their requirement for spore dispersal. Other contributions of these proteins to fungal biology are less clear and vary across genera.

Bioprospecting the Metabolome of Plant L.: A Fast Dereplication and Annotation Workflow in Plant Metabolomics.

Plants have a pivotal role in ethnopharmacology, and their preparations are in use globally. However, getting down to the structure requires an effective workflow and mostly requires a time-consuming isolation process. Although bioassay-guided approaches are widely popular, they face a massive problem of rediscovery in recent times, especially in plant metabolomics.

High Plasticity of the Amicetin Biosynthetic Pathway in sp. SHP 22-7 Led to the Discovery of Streptcytosine P and Cytosaminomycins F and G and Facilitated the Production of 12F-Plicacetin.

A chemical reinvestigation of the Indonesian strain sp. SHP 22-7 led to the isolation of three new pyrimidine nucleosides, along with six known analogues and zincphyrin. The structures of the new compounds (, , ) were elucidated by employing spectroscopic techniques (NMR, MS, CD, and IR) as well as enantioselective analyses of methyl branched side chain configurations.

LC-HRMS Profiling and Antidiabetic, Antioxidant, and Antibacterial Activities of (L.f.) Willd.

(L.f.) Willd is a profoundly used traditional medicinal plant in Asia.

Maculosin, a non-toxic antioxidant compound isolated from sp. KTM18.

Context: species are prolific sources of bioactive secondary metabolites known especially for their antimicrobial and anticancer activities.

Objective: This study sought to isolate and characterize antioxidant molecules biosynthesized by sp. KTM18.

Antidiabetic, Antimicrobial, and Molecular Profiling of Selected Medicinal Plants.

Natural products have been the center of attraction ever since they were discovered. Among them, plant-based natural products were popular as analgesics, anti-inflammatory, antidiabetic, and cosmetics and possess widespread biotechnological applications. The use of plant products as cosmetics and therapeutics is deep-rooted in Nepalese society.

Draft Genome Sequence of the Sattazolin-Producing Strain sp. C8, Isolated from a Mud Dauber Wasp Nest in Nepal.

Here, we report a 6.2-Mbp draft genome sequence of the bacterium sp. strain C8, which gave insight into the complete secondary metabolite production capacity of the strain and hinted that the strain possibly represents a new species.

Topological Phase Transition and Phonon-Space Dirac Topology Surfaces in ZrTe_{5}.

We use first-principles methods to demonstrate that, in ZrTe_{5}, a layered van der Waals material like graphite, atomic displacements corresponding to five of the six zone-center A_{g} (symmetry-preserving) phonon modes can drive a topological transition from a strong to a weak topological insulator with a Dirac semimetal state emerging at the transition, giving rise to a Dirac topology surface in the multidimensional space formed by the A_{g} phonon modes. This implies that the topological transition in ZrTe_{5} can be realized with many different settings of external stimuli capable of penetrating through the phonon-space Dirac surface without breaking the crystallographic symmetry. Furthermore, we predict that domains with effective mass of opposite signs can be created by laser pumping and will host Weyl modes of opposite chirality propagating along the domain boundaries.

Topological phase transition at the interface of a topological with a conventional insulator.

We study the topological states which appear at the interface between a topological insulator (TI) and a conventional insulator (CI) using effective Hamiltonians which accurately describe the band structure of the BiSe family. Due to the hybridization between the TI and the CI states, the band-gap that appears in the interface Dirac cone decreases and ultimately vanishes by tuning the interface-hopping amplitude or by selecting a CI of appropriate band effective mass. More importantly, we find that a topologically trivial TI slab can be made non-trivial and vice-versa by tuning of such an interface-hopping amplitude or by tuning the CI band effective-mass; namely, a topological phase transition can be induced in such heterostructures indicated by the presence or absence of gapless linear edge modes.

Draft Genome Sequence of sp. Strain C10, a Producer of Brartemicin, Isolated from a Mud Dauber Wasp Nest in Nepal.

sp. strain C10 produces the cytotoxic natural product brartemicin. Here, we report its draft genome sequence to get insight into brartemicin biosynthesis and to enable genome mining for novel secondary metabolites.

Biosynthesis of the nargenicin A1 pyrrole moiety from Nocardia sp. CS682.

A number of structurally diverse natural products harboring pyrrole moieties possess a wide range of biological activities. Studies on biosynthesis of pyrrole ring have shown that pyrrole moieties are derived from L-proline. Nargenicin A(1), a saturated alicyclic polyketide from Nocardia sp.