Artificial Intelligence Applications in Emergency Toxicology: Advancements and Challenges.

Emergency toxicology is a complex field requiring rapid and precise decision-making to manage acute poisonings effectively. Toxic exposures are often unpredictable, and the constraints of time and resources often challenge conventional diagnostic and treatment approaches. Artificial intelligence (AI) has emerged as a valuable tool in emergency medicine, offering the potential to enhance diagnostic accuracy, predict clinical outcomes and improve clinical decision support systems.

Climate change and environmental sustainability in emergency medicine: a narrative review.

Background And Objective: Climate change and global warming pose increasing threats to human health. These could have significant impact on healthcare systems, especially emergency services. In this narrative review, we aim to examine how climate change affects emergency attendances and operations, and to suggest strategies to reduce environmental impact through sustainability efforts.

The role of artificial intelligence in sepsis in the Emergency Department: a narrative review.

Background And Objective: Early recognition and treatment of sepsis in the emergency department (ED) is important. Traditional predictive analytics and clinical decision rules lack accuracy in identifying patients with sepsis. Artificial intelligence (AI) is increasingly prevalent in healthcare and offers application potential in the care of patients with sepsis.

Molecular basis of hemoglobin binding and heme removal in .

To successfully mount infections, nearly all bacterial pathogens must acquire iron, a key metal cofactor that primarily resides within human hemoglobin. causes the life-threatening respiratory disease diphtheria and captures hemoglobin for iron scavenging using the surface-displayed receptor HbpA. Here, we show using X-ray crystallography, NMR, and in situ binding measurements that selectively captures iron-loaded hemoglobin by partially ensconcing the heme molecules of its α subunits.

Assessing the Victim-Perpetrator Overlap in Adolescent Dating Violence in China: A Latent Class Analysis.

There is a limited understanding of the pathways that lead to victim-perpetrator overlap in adolescent dating violence (ADV) particularly in developing countries such as China. Applying a latent class approach, the present study focuses on whether the overlap can be explained by theoretical constructs grounded in social learning, general strain, and social bonding theories, and whether these constructs relate to underexplored mediating mechanisms or are direct precursors. The study sample consisted of 1,787 dating adolescents (39.

Acknowledging the need for traditional and complementary medicine education for pharmacists and students for the Chinese American population.

The prevalence of traditional and complementary medicine (T&CM) use is significant globally and within the United States, especially among Chinese Americans. However, there are misconceptions regarding the efficacy and safety of herbal medicines in comparison with conventional Western medications, and limited education, training, clinical application, and resources among pharmacists and pharmacy students. Pharmacists should be well equipped to holistically treat patients through required undergraduate education on the culture and foundation of T&CM along with interprofessional education experiences, a standardized and structured approach towards T&CM in the clinical practice setting, as well as systematic changes through advocacy among professional organizations and public health policies.

Perceived Ageism is Associated With Recurrent Falling Among Older Colombian Adults.

Literature on the association between ageism and falling among older adults is limited. Using data from the nationwide cross-sectional SABE () Colombia Survey in 2015 with 18,875 participants aged ≥60 years living in the communities, the study aims to evaluate the association between perceived ageism within the family, neighborhood, health services, and public services, and recurrent falling. Participants had a mean age of 69.

Scholar Metrics Scraper (SMS): automated retrieval of citation and author data.

Academic departments, research clusters and evaluators analyze author and citation data to measure research impact and to support strategic planning. We created Scholar Metrics Scraper (SMS) to automate the retrieval of bibliometric data for a group of researchers. The project contains Jupyter notebooks that take a list of researchers as an input and exports a CSV file of citation metrics from Google Scholar (GS) to visualize the group's impact and collaboration.

Quantifying the Kinetics of Pilus-Specific Sortase-Catalyzed Crosslinking Using High-Performance Liquid Chromatography.

Gram-positive bacteria display pili whose protein components (pilins) are covalently crosslinked by pilus-specific sortase enzymes. These cysteine transpeptidase enzymes catalyze a transpeptidation reaction that joins the pilins together via lysine isopeptide bonds. The crosslinking reaction that builds the SpaA pilus in Corynebacterium diphtheriae is mediated by the SrtA sortase (SrtA) and has been reconstituted in vitro.

Assessing the influence of preconception diet on female fertility: a systematic scoping review of observational studies.

Background: Preconception diet is a proposed modifiable risk factor for infertility. However, there is no official guidance for women in the preconception period as to which dietary approaches may improve fertility.

Objective And Rationale: A comprehensive synthesis of the relevant evidence is key to determine the potentially effective dietary patterns and components as well as evidence gaps, and to provide information for nutritional recommendations for couples planning a pregnancy.

The basal and major pilins in the Corynebacterium diphtheriae SpaA pilus adopt similar structures that competitively react with the pilin polymerase.

Many species of pathogenic gram-positive bacteria display covalently crosslinked protein polymers (called pili or fimbriae) that mediate microbial adhesion to host tissues. These structures are assembled by pilus-specific sortase enzymes that join the pilin components together via lysine-isopeptide bonds. The archetypal SpaA pilus from Corynebacterium diphtheriae is built by the SrtA pilus-specific sortase, which crosslinks lysine residues within the SpaA and SpaB pilins to build the shaft and base of the pilus, respectively.

The Basal and Major Pilins in the SpaA Pilus Adopt Similar Structures that Competitively React with the Pilin Polymerase.

Many species of pathogenic gram-positive bacteria display covalently crosslinked protein polymers (called pili or fimbriae) that mediate microbial adhesion to host tissues. These structures are assembled by pilus-specific sortase enzymes that join the pilin components together via lysine-isopeptide bonds. The archetypal SpaA pilus from is built by the SrtA pilus-specific sortase, which crosslinks lysine residues within the SpaA and SpaB pilins to build the shaft and base of the pilus, respectively.

Efficacy and Safety of Megestrol in the Hospitalized Older Person.

To evaluate the efficacy and safety of megestrol for off-label use in older patients with weight loss. Retrospective, nonblinded cohort study. Upstate University Hospital is a 420-bed facility and academic medical center with a level 1 trauma center.

Deviant Versus Nondeviant Routines, Social Guardianship and Adolescent Victimization in the Rural Context of China.

There is limited knowledge on the possible pathways of victimization among rural dwellers during adolescence in developing contexts, such as rural China, where victimization may compound developmental disadvantages of rural adolescents. Guided by the lifestyle/routine activity theory, the goal of this study thus was to examine how far delinquent lifestyles (delinquent involvement and delinquent peer association); nondeviant routine activities (unstructured socializing with peers, structured activities, and solitary activities); and social guardianship within family, school, and neighborhood contribute to juvenile victimization in a rural setting. The outcomes of interest covered direct victimization (violent, property, and sexual) and indirect victimization (witnessing community violence).

Do Gender Norms Matter? General Strain Theory and a Gendered Analysis of Gambling Disorder among Chinese Married Couples.

Despite the emergence of literature on gender differences in gambling problems, few empirical studies have explored how gender norms inform the gender dynamics involved in the development of gambling disorder. This study addresses this research gap by applying general strain theory to gambling disorder across genders. The objectives of this study are twofold.

What is the right sequencing approach? Solo VS extended family analysis in consanguineous populations.

Background: Testing strategies is crucial for genetics clinics and testing laboratories. In this study, we tried to compare the hit rate between solo and trio and trio plus testing and between trio and sibship testing. Finally, we studied the impact of extended family analysis, mainly in complex and unsolved cases.

Ceftolozane-tazobactam and ceftazidime-avibactam activity against β-lactam-resistant Pseudomonas aeruginosa and extended-spectrum β-lactamase-producing Enterobacterales clinical isolates from U.S. medical centres.

Background: Despite availability of ceftolozane-tazobactam (C/T) and ceftazidime-avibactam (CZA) for several years, the individual spectrum of activity of each agent may not be widely known. We compared the activity of C/T and CZA against convenience samples of 119 extended-spectrum β-lactamase (ESBL)-producing Enterobacterales and 60 β-lactam-resistant Pseudomonas aeruginosa clinical isolates collected from three U.S.

Adolescent Drug Abuse in Hong Kong: Prevalence, Psychosocial Correlates, and Prevention.

Purpose: Hong Kong has devised strategies to tackle the problem of psychoactive drug abuse in adolescents since the mid-1990s. This paper sought to find out whether previous research and prevention work has made use of concepts and ideas that are akin to the Positive Youth Development (PYD) approach. The prospect of adopting PYD in Hong Kong's drug prevention system was explored.

Natural fertility, infertility and the role of medically assisted reproduction: The knowledge amongst women of reproductive age in North Queensland.

Background: The demand for medically assisted reproduction continues to increase, with more women encountering challenges with fertility. Due to misconceptions and gaps in knowledge, women are often unaware of the risks related to delayed childbearing. Lack of understanding of natural fertility, infertility and the role of medically assisted reproduction can lead to emotional suffering and changes in family plans.

Social strain, couple dynamics and gender differences in gambling problems: evidence from Chinese married couples.

Knowledge of the influence of couple dynamics on gender differences in gambling behavior remains meager. Building on general strain theory from the sociology of deviance and stress crossover theory from social psychology, we argue that the strain encountered by one partner in a social setting may affect his or her spouse. For instance, the wife of a man under more social strain may experience more strain in turn and thus be at a higher risk of developing disordered gambling than the wife of a man under less social strain.

Social stress, locality of social ties and mental well-being: the case of rural migrant adolescents in urban China.

By comparing rural migrant and urban native adolescents in Guangzhou, the largest city in south China, this study investigated the relationships between social stress, social ties that link migrants to their host cities (local ties) and to their rural home communities (trans-local ties), and the migrants׳ mental well-being. Non-migration social stress was more strongly related to poor psychological health than to weak self-efficacy in both migrant and urban native adolescents. This pattern also applied to the effect of migration-specific assimilation stress on psychological health and self-efficacy in migrants.

Rural-to-urban migrant adolescents in Guangzhou, China: psychological health, victimization, and local and trans-local ties.

Despite the emerging literature on the health of rural-to-urban migrant children in China, few studies have addressed victimization stressors and stress-buffering mechanisms related to the social relationships that link migrants to their host cities (local ties) and home communities (trans-local ties). This study compared rural-to-urban migrant adolescents and urban native adolescents to examine the relationships between victimization, local and trans-local ties, and mental well-being that might be unique to migrants. Participants were 482 migrant students and 838 urban native students in the eighth grade in Guangzhou who completed a school-based survey in spring 2011.

Low self-control and co-occurrence of gambling with substance use and delinquency among Chinese adolescents.

Relatively little is known about gambling co-morbidity in Asian youth populations. The role of trait self-control in co-morbidity also remains under-explored in the gambling literature. This study examined the association between gambling, substance use and delinquency among Chinese adolescents, and the extent to which these forms of risk behavior are commonly predicted by low self-control.

Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma.

To identify potential oncofetal biomarkers that distinguish hepatocellular carcinoma (HCC) from healthy liver tissues, we compared and analyzed the proteomic profiles of mouse livers at different developmental stages. Fetal (E13.5, E16.