Publications by authors named "Nick Howell"

Understanding the spatial distribution of gene expression in the pancreas is essential for establishing the molecular basis of pancreatic function in healthy and disease contexts. Recent platforms offer a robust method for quantifying gene expression within a spatial context. Here, we report spatial transcriptomic profiling from pancreas samples obtained from three donors with type 2 diabetes (T2D) and three donors with normal glucose tolerance (NGT).

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A pedunculated exophytic mass developed on the rump of a dog. Fine-needle aspiration revealed keratin debris suggestive of a follicular tumor. However, histology revealed a pigmented viral plaque that contained numerous keratin-filled cystic cavities.

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Crab has been designated by the ICRP as one of twelve reference/model organisms for understanding the impacts of radionuclide releases on the biosphere. However, radionuclide-crab interaction data are sparse compared with other reference organisms (e.g.

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The adsorption of radiocesium and radiostrontium onto a range of natural materials has been well quantified, but not for the new media of environmental plastics, which may have enhanced adsorption due to surface-weathering and development of biofilms. Microplastic samples were deployed in freshwater, estuarine and marine conditions, then characterised using infrared spectroscopy to document changes to the plastic surface (vs interior). Synchrotron elemental mapping data revealed surfaces that were well-covered by accumulation of reactive water solutes and sulphur, but, in contrast, had highly discrete coverage of elements such as Fe and Ti, indicating adhered mineral/clay-associated agglomerates that may increase overall adsorption capacity.

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