Endometrial Mesonephric-Like Carcinoma With Prominent Clear Cell Carcinoma-Like Features.

This report details findings from a morphologic, immunohistochemical, and molecular analysis of an example of endometrial mesonephric-like adenocarcinoma (MLA) with prominent clear cell carcinoma (CCC)-like features, with an assessment of whether such tumors represent mixed MLA/CCC or a morphologic subtype of MLA. Approximately 40% of an otherwise prototypical MLA was comprised of spatially discrete zones with prominent CCC-like morphology. The MLA-like nuclear features of both components were similar, as were their immunoreactivity patterns for estrogen receptor, progesterone receptor, SOX17, and calretinin (all negative), GATA3, and TTF1 (patchy positive).

Detection of cytogenetically cryptic PML-RARA fusion in acute promyelocytic leukemia by rapid next generation sequencing.

Acute promyelocytic leukemia (APL) is a medical emergency that requires treatment to be initiated as soon as the disease is suspected in order to decrease the risk of early death, which is mostly caused by APL-associated coagulopathy. Currently, the diagnosis of APL relies on the detection of PML-RARA fusion by fluorescence in situ hybridization (FISH). However, rare cases are cytogenetically cryptic, negative by FISH, and require other molecular techniques to detect the fusion.

Molecular findings in endometrial mucinous carcinoma of the gastric [Gastrointestinal] type: A report of 5 additional cases and a systematic review of the literature.

The authors summarize the somatic mutational landscape of endometrial mucinous carcinoma of the gastric (gastrointestinal) type [MCG], based on findings from a 5-case cohort and a systematic review of the literature, the latter including 25 cases from 3 published reports. The 30 cases were analyzed by variably-sized next generation sequencing gene panels, and featured 74 total mutations, including 20 unique mutations [mean 2.47 ± 1.

A Novel Fusion in a Poorly Differentiated Carcinoma Involving the Lung and Mediastinum.

Cancer genetics studies have dramatically advanced the understanding of the molecular drivers in various types of neoplasms. This progress is also leading to the discovery of more new molecular agents to block those drivers, which has significantly improved cancer patient survival, especially in non-small cell lung cancer (NSCLC). However, in about 25% of NSCLC tumors molecular drivers are not yet known.

Research Funding, Income, and Career Satisfaction Among Clinician-Scientists in Ophthalmology in the United States.

Purpose: The purpose of this study was to characterize clinician-scientists in ophthalmology and identify factors associated with successful research funding, income, and career satisfaction.

Design: Cross-sectional study.

Methods: A survey was conducted of clinician-scientists in ophthalmology at US academic institutions between April 17, 2019, and May 19, 2019.

PREVALENCE OF MISMATCH REPAIR GENE MUTATIONS IN UVEAL MELANOMA.

Purpose: Uveal melanomas are associated with characteristic genetic changes. Germline mutations in mismatch repair (MMR) genes and microsatellite instability have been implicated in the development of numerous malignant neoplasms such as colon and ovarian cancers. The frequency of MMR defects in uveal melanomas has yet to be determined.

Interleukin-22 promotes tumor angiogenesis.

T17 cells play important yet complex roles in cancer development and progression. We previously reported that T17 cells and IL-17 mediate resistance to anti-VEGF therapy by inducing recruitment of immunosuppressive and proangiogenic myeloid cells to the tumor microenvironment. Here, we demonstrate that IL-22, a key effector cytokine expressed by T17 cells, directly acts on endothelial cells to promote tumor angiogenesis.