Recent Advances in the Management of EGFR-Mutated Advanced Non-Small Cell Lung Cancer-A Narrative Review.

The treatment landscape for EGFR-mutated metastatic non-small cell lung cancer (mNSCLC) has evolved significantly with multiple combination regimens demonstrating superiority over single agent Osimertinib over the past two years. Recent trials such as FLAURA2 and MARIPOSA have explored intensified front-line regimens, with FLAURA2 demonstrating improvement in PFS with the addition of chemotherapy to Osimertinib and MARIPOSA, showing both a PFS and OS benefit with a novel combination regimen of Amivantamab and Lazertinib. However, these regimens are associated with significantly higher toxicity to patients and pose a huge financial and logistical burden to the health care system; therefore, treatment selection must therefore be individualized, considering disease biology, patient fitness, and toxicity burden.

Factors Associated With Contraceptive Initiation and Use Among Women Who Have Given Birth in the Last Year: Findings From the 2023 Women's Reproductive Health Survey.

Objective: This study investigates contraceptive use among individuals who have recently given birth. It aims to identify factors associated with contraceptive use at two months and one-year of giving birth. Additionally, it assesses whether receiving and being satisfied with contraceptive counselling influences contraceptive use.

Efficacy and Safety of Metastatic Directed Treatment of Oligometastatic Disease: Results of a Meta-analysis.

Purpose: In patients with oligometastatic disease (OMD), local therapy to metastatic sites has gained acceptance despite uncertainty regarding its long-term benefits or whether some subgroups would benefit more than others. Here, we report a meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the efficacy and safety of adding stereotactic radiation to metastases versus the standard of care (SOC) in treating OMD.

Methods And Materials: A meta-analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Adverse effect of trastuzumab deruxtecan in solid tumours: A systematic review and meta-analysis.

Introduction: Trastuzumab deruxtecan (T-DXd) is approved for use in numerous solid tumours. Here we summarize its safety and tolerability profile.

Methods: Studies were identified from MEDLINE, EMBASE and recent conference proceedings.

Continuing Cyclin-Dependent Kinase 4/6 Inhibitors Beyond Progression in Advanced Breast Cancer: A Meta-Analysis.

The use of cyclin-dependent kinase 4/6 inhibitors (CDK 4/6i) with endocrine therapy (ET) is a first-line standard treatment for hormone receptor-positive (ER+) Human Epidermal Growth factor Receptor-2-negative (HER2-) advanced breast cancer. The data supporting incorporation of CDK 4/6i + ET beyond progression are variable. Here, we report a pooled analysis of this strategy.

Safety and Effectiveness of Adriamycin and Cyclophosphamide Followed by Dose Dense (Every 2 Weeks) Paclitaxel Given With Trastuzumab as Neoadjuvant Treatment in HER2-Positive Early-Stage Breast Cancer.

Background: Traditionally, in neoadjuvant anthracycline-based chemotherapy for early-stage HER2+ breast cancer, paclitaxel is administered weekly for 12 doses combined with trastuzumab every 3 weeks (ACTH-W). In Ontario Canada, an alternative protocol consists of administering paclitaxel every 2 weeks concurrently with trastuzumab every 2 weeks for 4 doses (ACTH-O).

Methods: We conducted a retrospective, single-institution chart review of sequential patients treated between 2014 and 2023 to evaluate the efficacy, safety, and resource utilization of ACTH-O compared with FEC-DH, TCH, and ACTH-W.

Exercise interventions for older adults with advanced cancer: A scoping review.

Introduction: The feasibility, safety, acceptability, and perceptions of exercise in older adults with advanced disease are not well understood due to the scarcity of evidence. This scoping review aimed to (1) summarize evidence on the feasibility, acceptability, and safety of exercise interventions for older adults with advanced cancer and (2) explore this population's perceptions on participating in exercise programs.

Materials And Methods: A systematic search was conducted by an expert research librarian in Medline, CINAHL, EMBASE, Cochrane CENTRAL, and SPORTDiscus (inception through November 2023).

Young Onset Lung Cancer in India: Insights Into Clinical, Demographic, and Genomic Profiles.

Background: Lung cancer (LC) is traditionally perceived as a disease primarily affecting the elderly. However, individuals under the age of 40 represent a rare subset, accounting for up to 6% of all LC cases. There is limited information about demographic, clinical, pathological, and molecular features and treatment outcomes of young-onset LC.

Systematic Review and Network Meta-Analysis on Treating Hormone Receptor-Positive Metastatic Breast Cancer After CDK4/6 Inhibitors.

Introduction: The optimal treatment of estrogen receptor-positive (ER +) metastatic breast cancer (MBC) after progression on cyclin-dependent 4/6 kinase inhibitors (CDK4/6i) is unknown.

Methods: We conducted a systematic review and network meta-analysis (NMA) of phase-II/-III randomized trials of ER + MBC post CDK4/6i + ET progression. We calculated the hazard ratio (HR) for progression-free survival (PFS) and overall survival (OS) using generic inverse variance and odds ratios (ORs) using the Mantel-Haenszel method for adverse events (AEs) with Review-Manager version-5.

Steatotic liver disease in metastatic breast cancer treated with endocrine therapy and CDK4/6 inhibitor.

Purpose: In early-stage breast cancer, steatotic liver disease (SLD) is associated with increased recurrence, cardiovascular events, and non-cancer death. Endocrine therapy (ET) increases the risk of SLD. The impact of cyclin-dependent kinases 4/6 inhibitors (CDK4/6i) on SLD and prognostic association in metastatic breast cancer is unknown.

Racial/ethnic discrimination and racial trauma: Concurrent evaluation among Black adults who smoke in the United States.

Objective: Although Black/African American (hereinafter Black) adults who smoke are a tobacco disparities population in the United States, little systematic research has sought to explicate how differences in the distinct experience of race-related threat are associated with established and clinically important smoking processes in one overarching model. The present investigation sought to bridge this gap and test perceived racial/ethnic discrimination and racial trauma in the context of one another regarding an array of processes involved in the maintenance and relapse of smoking behavior.

Method: Participants included 517 Black individuals who smoked cigarettes daily (≥ 5; = 45.

Frailty in Older Adults with Prostate Cancer.

Older adults with all stages of prostate cancer are prone to developing frailty. These patients should have a frailty assessment and be managed by a multidisciplinary team. Lifestyle measures and tailoring of cancer-related treatment to the patient's fitness level can help in mitigating the adverse effects of frailty.

Autologous Stem Cell Transplantation in Adult Hodgkin Lymphoma at a Tertiary Care Center in India: Analysis of Outcomes and Prognostic Factors.

Unlabelled: High-dose chemotherapy and autologous stem cell transplant (ASCT) is the standard of care treatment in relapsed/refractory Hodgkin lymphoma (rrHL). Published long-term follow-up data concerning this modality from the Indian subcontinent is lacking. In this retrospective study, the data on adults (> 16 years) with biopsy-confirmed rrHL who were autografted from 1 January 2000 to 31 December 2021 at our transplant unit were analyzed.

Sexual and reproductive health and rights of migrant women attending primary care in England: A population-based cohort study of 1.2 million individuals of reproductive age (2009-2018).

Background: Evidence on the sexual and reproductive health and rights (SRHR) of migrants is lacking globally. We describe SRHR healthcare resource use and long-acting reversible contraceptives (LARCs) prescriptions for migrant versus non-migrant women attending primary care in England (2009-2018).

Methods: This population-based observational cohort study, using Clinical Practice Research Datalink (CPRD) GOLD, included females living in England aged 15 to 49.

End Users' Perceived Engagement with Clinical Dashboards: A Rapid Review.

Clinical dashboards are an emerging and fast-evolving technology used to support frontline clinicians' practice. Understanding end users' perceived engagement with clinical dashboards is essential to co-design, implementation, and adoption. There is a lack of literature exploring the integration of dashboards into clinical workflow.

Developing a Quality Improvement Implementation Taxonomy for Organizational Employee Wellness Initiatives.

Background: Standardized taxonomies (STs) facilitate knowledge representation and semantic interoperability within health care provision and research. However, a gap exists in capturing knowledge representation to classify, quantify, qualify, and codify the intersection of evidence and quality improvement (QI) implementation. This interprofessional case report leverages a novel semantic and ontological approach to bridge this gap.

Developing a Quality Improvement Implementation Taxonomy for Organizational Employee Wellness Initiatives.

Background: Standardized taxonomies (STs) facilitate knowledge representation and semantic interoperability within health care provision and research. However, a gap exists in capturing knowledge representation to classify, quantify, qualify, and codify the intersection of evidence and quality improvement (QI) implementation. This interprofessional case report leverages a novel semantic and ontological approach to bridge this gap.

Quality of life assessment in testicular non-seminomatous germ cell tumour survivors.

Purpose: Patients with Germ cell tumours (GCT) are at risk of long-term toxicities due to multimodality therapy. It is debatable whether there is an impact on the quality of life(QoL) of GCT survivors.

Methods: A case-control study was conducted at a tertiary care centre in India, using the EORTC QLQ C30 questionnaire, to compare the QoL between GCT survivors(disease free > 2 years) and healthy matched controls.

The proactive-reactive classification of intimate partner violence offenders: A multi-method approach to classification.

Background: Men who commit violence against an intimate partner differ in their motives. Classifying the proactivity of men's partner violence may reveal important differences that could be treatment targets.

Aims: To examine the differences between proactive and reactive partner violence based on coded descriptions of past violent events.