Metalloplastic interaction triggers renal oxeiptosis: Novel insights into KEAP1/PGAM5/AIFM1 pathway in snakeheaded fish Channa punctatus.

Oxeiptosis, discovered in 2018, is a ROS-triggered, caspase-independent cell death pathway studied so far only in mammals. Our study provides the first validation of oxeiptosis in an aquatic organism, expanding the understanding of oxidative stress-mediated cell death pathways in fish. Channa punctatus were exposed to environmentally relevant concentrations of Polyvinyl chloride microplastics (PVC-MPs) (0.

Neurotoxic synergy of copper and PVC microplastics triggers apoptosis via the BDNF/miR132/FOXO3a pathway for the first time in fish brain.

Copper (Cu) and polyvinyl chloride microplastics (PVC-MPs), each known for their toxic effects, combine to create a hazardous synergy, posing a dual threat to aquatic ecosystems. Our study investigates the chronic (60-day) neurotoxic impacts of environmentally relevant concentrations of Cu (0.85 mg/L) and PVC-MPs (0.

Unveiling the crosstalk between unfolded protein response and apoptosis in triclosan induced hepatotoxicity in Labeo rohita.

Triclosan (TCS), a widely used antimicrobial, has emerged as a concerning aquatic pollutant, especially post-COVID-19 due to increased disinfectant use. The study aimed to investigate the toxic impacts of TCS on Labeo rohita, revealing a 96-h LC of 0.742 mg/L.

Curcumin's role in reshaping the redox dynamics of fish kidneys: NRF2 activation as a strategy against copper-induced nephropathy.

From essential to harmful, excess copper compromises aquatic vitality. Curcumin, a potent antioxidant bioactive, counteracts heavy metal toxicity. This study examines its role in modulating the NRF2-KEAP1 pathway to boost antioxidant defenses and mitigate apoptosis in kidneys of Channa punctatus exposed to environmentally relevant Copper concentrations (ERCC).

The cascade of cadmium toxicity: from cellular damage to pyroptotic responses in fish Channa punctatus.

Cadmium pollution is a major environmental issue threatening aquatic ecosystems and the health of aquatic organisms. Our study examines cadmium toxicity at different levels, highlighting pyroptotic cell death in the freshwater fish Channa punctatus (spotted snakehead). For this purpose, 90 well-acclimatized fish were categorized into three groups: one control and two treatment groups, i.