Publications by authors named "Nayra A Martin-Key"

Background: While there exist safe hormonal and non-hormonal therapeutic interventions for the menopause, their efficacy profiles are not fully characterized. This study sought to use a symptom checklist to examine menopausal symptom relief associated with different treatments.

Methods: An online survey study was conducted between December 2023 and February 2024.

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Background: Menopause presents a period of heightened vulnerability for mental health issues. Despite this, mental health screening is not consistently integrated into menopausal health care, and access to psychological interventions is limited. Digital technologies, such as web and smartphone apps, may offer a way to facilitate and improve mental health care provision throughout menopause.

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Background: Mental health care provision in the United Kingdom is overwhelmed by a high demand for services. There are high rates of under-, over-, and misdiagnosis of common mental health disorders in primary care and delays in accessing secondary care. This negatively affects patient functioning and outcomes.

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Background: Misdiagnosis and delayed help-seeking cause significant burden for individuals with mood disorders such as major depressive disorder and bipolar disorder. Misdiagnosis can lead to inappropriate treatment, while delayed help-seeking can result in more severe symptoms, functional impairment, and poor treatment response. Such challenges are common in individuals with major depressive disorder and bipolar disorder due to the overlap of symptoms with other mental and physical health conditions, as well as, stigma and insufficient understanding of these disorders.

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Background: Every year, one-fourth of the people in the United Kingdom experience diagnosable mental health concerns, yet only a proportion receive a timely diagnosis and treatment. With novel developments in digital technologies, the potential to increase access to mental health assessments and triage is promising.

Objective: This study aimed to investigate the current state of mental health provision in the United Kingdom and understand the utility of, and interest in, digital mental health technologies.

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Digital mental health interventions (DMHI) have the potential to address barriers to face-to-face mental healthcare. In particular, digital mental health assessments offer the opportunity to increase access, reduce strain on services, and improve identification. Despite the potential of DMHIs there remains a high drop-out rate.

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Article Synopsis
  • Patients with bipolar disorder are often mistakenly diagnosed with major depressive disorder, leading to increased healthcare costs and system strain.
  • This study assessed a novel screening tool for bipolar disorder, comparing its effectiveness to the existing Mood Disorder Questionnaire in a large primary care setting.
  • Results showed the new screening reduced misdiagnoses significantly and saved about $21.3 million over five years, suggesting such tools can improve both patient outcomes and healthcare efficiency.*
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  • The review assesses the effectiveness and accuracy of digital tools that use Q&A formats for diagnosing and screening mental health conditions in adults.
  • A systematic search of numerous databases identified 28 studies, focusing mainly on generalized anxiety and major depressive disorders.
  • Results show a wide range of diagnostic accuracy among these tools, from poor to excellent, but most studies exhibited a high risk of bias, indicating that the digital mental health field still needs more reliable evidence.
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Background: The ever-increasing pressure on health care systems has resulted in the underrecognition of perinatal mental disorders. Digital mental health tools such as apps could provide an option for accessible perinatal mental health screening and assessment. However, there is a lack of information regarding the availability and features of perinatal app options.

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Background: Diagnosing major depressive disorder (MDD) is challenging, with diagnostic manuals failing to capture the wide range of clinical symptoms that are endorsed by individuals with this condition.

Objective: This study aims to provide evidence for an extended definition of MDD symptomatology.

Methods: Symptom data were collected via a digital assessment developed for a delta study.

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  • SSRIs are commonly used to treat depression, but their effectiveness can differ among patients, prompting a study to identify factors that predict how well someone may respond to these medications.
  • Using data from an online mental health questionnaire and advanced analysis techniques, researchers found that positive affectivity was the strongest predictor of SSRI response, while chronic pain, sleep problems, and unemployment negatively impacted treatment perception.
  • The study highlighted the need for caution in interpreting results due to its exploratory nature, reliance on self-reported data, and the necessity for further research to confirm these findings.
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Digital mental health technologies such as mobile health (mHealth) tools can offer innovative ways to help develop and facilitate mental health care provision, with the COVID-19 pandemic acting as a pivot point for digital health implementation. This viewpoint offers an overview of the opportunities and challenges mHealth innovators must navigate to create an integrated digital ecosystem for mental health care moving forward. Opportunities exist for innovators to develop tools that can collect a vast range of active and passive patient and transdiagnostic symptom data.

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Background: Perinatal mental health symptoms commonly remain underdiagnosed and undertreated in maternity care settings in the United Kingdom, with outbreaks of disease, like the COVID-19 pandemic, further disrupting access to adequate mental health support. Digital technologies may offer an innovative way to support the mental health needs of women and their families throughout the perinatal period, as well as assist midwives in the recognition of perinatal mental health concerns. However, little is known about the acceptability and perceived benefits and barriers to using such technologies.

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Article Synopsis
  • - The Delta Study aimed to enhance the diagnosis of mood disorders in people with low mood, seeking to estimate their prevalence and characteristics, and how these findings can influence clinical practices.
  • - Participants were classified into three groups based on their mood disorder history, and comprehensive mental health data was gathered online using standardized assessments to establish accurate diagnoses.
  • - Findings revealed significant under- and misdiagnosis rates, with notable percentages of Bipolar Disorder (BD) and Major Depressive Disorder (MDD) among participants; this highlights the necessity for better mental health screening in primary care to prevent worsening symptoms.
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  • Web-based mental health assessments can provide earlier and more cost-effective diagnoses for psychiatric conditions than traditional methods, particularly for those showing symptoms of depression.
  • A study with over 2000 participants assessed the impact of a web-based assessment that offered personalized feedback and psychoeducation, leading to positive self-reported outcomes in mental well-being after 6 and 12 months.
  • While a majority found the web assessment useful for understanding their mental health, a small percentage actually discussed their results with professionals, resulting in limited new diagnoses despite the assessment's predictive accuracy.
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Adolescents with Conduct Disorder (CD) show deficits in recognizing facial expressions of emotion, but it is not known whether these difficulties extend to other social cues, such as emotional body postures. Moreover, in the absence of eye-tracking data, it is not known whether such deficits, if present, are due to a failure to attend to emotionally informative regions of the body. Male and female adolescents with CD and varying levels of callous-unemotional (CU) traits (n = 45) and age- and sex-matched typically-developing controls (n = 51) categorized static and dynamic emotional body postures.

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Background: This study investigated the clinical utility of the combined use of objective and subjective measures of attention-deficit/hyperactivity disorder (ADHD) prepharmacological and postpharmacological treatment.

Methods: Adults with ADHD (N = 77) completed the Quantified Behavioral Test, self-ratings of ADHD-related symptoms, and quality of life measures pretreatment and posttreatment.

Results: The use of objective and subjective measures of ADHD-related symptoms during initiation and follow-up of pharmacological treatment resulted in significant improvements in quality of life after 6 months.

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  • Mood disorders often suffer from under- and misdiagnosis, which leads to ineffective treatment and poor outcomes; this study aimed to create a diagnostic algorithm to differentiate bipolar disorder (BD) from major depressive disorder (MDD).
  • Researchers recruited individuals aged 18-45 with depressive symptoms online, using a mental health questionnaire and blood samples for biomarker analysis, alongside established diagnostic interviews.
  • The developed algorithm showed a high accuracy in distinguishing BD from MDD with an AUROC of 0.92, and further validation confirmed its effectiveness across different patient groups, potentially improving timely diagnosis and treatment for BD.
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Background: Despite the rapidly growing number of digital assessment tools for screening and diagnosing mental health disorders, little is known about their diagnostic accuracy.

Objective: The purpose of this systematic review and meta-analysis is to establish the diagnostic accuracy of question- and answer-based digital assessment tools for diagnosing a range of highly prevalent psychiatric conditions in the adult population.

Methods: The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) will be used.

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