Magnetic Resonance Imaging for Improved Brain Tumor Detection.

Precise demarcation of brain tumor boundaries is critical for optimizing treatment strategies and improving patient outcomes. characterization of tumor using PET/CT and MRI is clinical standard. PET/CT highlights the metabolic aspects of the tumor, while MRI provides information on functional, metabolic and structural changes.

Detection of sex-specific glutamate changes in subregions of hippocampus in an early-stage Alzheimer's disease mouse model using GluCEST MRI.

Introduction: Regional glucose hypometabolism resulting in glutamate loss has been shown as one of the characteristics of Alzheimer's disease (AD). Because the impact of AD varies between the sexes, we utilized glutamate-weighted chemical exchange saturation transfer (GluCEST) magnetic resonance imaging (MRI) for high-resolution spatial mapping of cerebral glutamate and investigated subregional changes in a sex-specific manner.

Methods: Eight-month-old male and female AD mice harboring mutant amyloid precursor protein (APP: n = 36) and wild-type (WT: n = 39) mice underwent GluCEST MRI, followed by proton magnetic resonance spectroscopy (H-MRS) in hippocampus and thalamus/hypothalamus using 9.

Early-stage mapping of macromolecular content in APP mouse model of Alzheimer's disease using nuclear Overhauser effect MRI.

Non-invasive methods of detecting early-stage Alzheimer's disease (AD) can provide valuable insight into disease pathology, improving the diagnosis and treatment of AD. Nuclear Overhauser enhancement (NOE) MRI is a technique that provides image contrast sensitive to lipid and protein content in the brain. These macromolecules have been shown to be altered in Alzheimer's pathology, with early disruptions in cell membrane integrity and signaling pathways leading to the buildup of amyloid-beta plaques and neurofibrillary tangles.

In vivo assessment of β-hydroxybutyrate metabolism in mouse brain using deuterium ( H) MRS.

Purpose: To monitor the metabolic turnover of β-hydroxybutyrate (BHB) oxidation using H-MRS in conjunction with intravenous administration of H labeled BHB.

Methods: Nine-month-old mice were infused with [3,4,4,4]- H -BHB (d -BHB; 3.11 g/kg) through the tail vein using a bolus variable infusion rate for a period of 90 min.

Feasibility of transient nuclear Overhauser effect imaging in brain at 7 T.

Purpose: The nuclear Overhauser effect (NOE) quantification from the steady-state NOE imaging suffers from multiple confounding non-NOE-specific sources, including direct saturation, magnetization transfer, and relevant chemical exchange species, and is affected by B and B inhomogeneities. The B -dependent and B -dependent data needed for deconvolving these confounding effects would increase the scan time substantially, leading to other issues such as patient tolerability. Here, we demonstrate the feasibility of brain lipid mapping using an easily implementable transient NOE (tNOE) approach.

Identification of l-Tryptophan by down-field H MRS: A precursor for brain NAD and serotonin syntheses.

Purpose: To explore the presence of new resonances beyond 9.4 ppm from the human brain, down-field proton MRS was performed in vivo in the human brain on 6 healthy volunteers at 7 T.

Methods: To maximize the SNR, a large voxel was placed within the brain to cover the maximal area in such a way that sinus cavities were avoided.

Brain energy metabolism in intracerebroventricularly administered streptozotocin mouse model of Alzheimer's disease: A H-[C]-NMR study.

Alzheimer's disease (AD) is a very common neurodegenerative disorder. Although a majority of the AD cases are sporadic, most of the studies are conducted using transgenic models. Intracerebroventricular (ICV) administered streptozotocin (STZ) animals have been used to explore mechanisms in sporadic AD.