Trends in the Utilization of and Testing After the Introduction of a Publicly Funded Genetic Testing Program.

Purpose: To effectively reduce cancer burden, genetic testing programs should identify high-risk individuals prior to cancer development, when risk-reduction strategies can be implemented. We evaluated trends in / testing use after implementation of a publicly funded testing program.

Methods: We conducted a retrospective, near population-based study of women who underwent / testing in Ontario, Canada, (2007-2016) ( = 15,986).

Long-Term Durability of Active Surveillance of Small, Low-Risk Papillary Thyroid Cancer.

Importance: In managing early-stage cancers, active surveillance (AS) may be preferentially favored by older individuals. In counseling patients, it is important to understand the durability of AS in the context of age.

Objective: To evaluate the durability of AS in patients with small, low-risk papillary thyroid cancer (PTC) according to age at the time of choosing AS.

H, N and C backbone resonance assignments of flap endonuclease from Plasmodium falciparum.

Flap endonuclease (FEN) enzymes are a group of metallonucleases that have essential roles in DNA repair and the maintenance of genomic resilience. They catalyse hydrolytic cleavage of a phosphodiester bond to remove 5'-flaps present on double-stranded DNA molecules formed during DNA replication. FEN locates a target scissile bond through the structural recognition of a pronounced bend in the double-stranded DNA substrate along with the presence of both a 5'-flap and a 1-nucleotide 3'-flap.

Patient-Reported Symptoms and Mental Health Event Risks in Adolescents and Young Adults With Cancer.

Introduction: Adolescents and young adults (AYA) with cancer are at risk of adverse mental health outcomes during and after treatment. Tools identifying AYA at the highest risk would guide screening and interventions. We determined whether self-reported symptoms following cancer diagnosis were associated with early and late severe mental health events (SMHEs).

Aquaporin-4-positive neuromyelitis optica in a male Caucasian patient: A rare demographic presentation.

Neuromyelitis optica with a positive aquaporin-4 antibody is a rare autoimmune condition, which has a higher prevalence in females, and disproportionately affects Black and Asian persons with a typical age of first presentation between the ages of 30 and 40. We report a unique case of a 69-year-old Caucasian male who presented following a fall along with generalised weakness, unilateral myotomal pain, and urinary dysfunction. His medical history included two previous venous thromboembolic events, for which he was anticoagulated with warfarin.