Evolution of Blood Innate Immune Cell Phenotypes Following SARS-CoV-2 Infection in Hospitalized Patients with COVID-19.

Innate immune cells appear to have an important implication in the resolution and/or the aggravation of the COVID-19 pathogenesis after infection with SARS-CoV-2. To better appreciate the role of these cells during COVID-19, changes in blood eosinophil, the neutrophil and monocyte count, and levels of surface protein markers have been reported. However, analyses at several timepoints of multiple surface markers on granulocytes and monocytes over a period of one month after a SARS-CoV-2 infection are missing.

Evaluation of a Multiplex Electrochemiluminescence Assay for Detection of Anti-Pneumococcal Antibodies in the Diagnosis of Selective Polysaccharide Antibody Deficiency.

Streptococcus pneumoniae can be responsible for severe infections, especially in patients with primary antibody deficiencies like selective anti-polysaccharide antibodies deficiency (SPAD). The reference method recommaned by the World Health Organization for assessment of anti-pneumococcal capsular polysaccharides (PCPs) IgG antibodies is a standardized serotype-specific ELISA (WHO-SSA), but this manual method is time-consuming and limit the number of evaluated PCPs. We aim to evaluate the performance values of a multiplex assay based on electrochemiluminescence (ECL-plex).

Characterisation of the Novel HLA-A*03:512 Allele by Sequencing-Based Typing.

HLA-A*03:512 differs from HLA-A*03:01:01:01 by one nucleotide substitution in codon 238 in exon 4.

Characterisation of the Novel HLA-C*06:406 Allele by Sequencing-Based Typing.

HLA-C*06:406 differs from HLA-C*06:02:01:01 by one nucleotide substitution in codon 201 in exon 4.

Characterisation of the Novel HLA-DQB1*06:03:57 Allele by Sequencing-Based Typing.

HLA-DQB1*06:03:57 differs from HLA-DQB1*06:03:01:01 by one nucleotide substitution in codon 21 in exon 2.

Characterisation of the Novel HLA-DQB1*05:356 Allele by Sequencing-Based Typing.

HLA-DQB1*05:356 differs from HLA-DQB1*05:03:01:01 by one nucleotide substitution in codon 14 in exon 2.

Characterisation of the Novel HLA-DQB1*05:357 Allele by Sequencing-Based Typing.

HLA-DQB1*05:357 differs from HLA-DQB1*05:03:01:01 by one nucleotide substitution in codon 6 in exon 2.

Characterisation of the Novel HLA-C*16:01:01:42Q Allele by Sequencing-Based Typing.

HLA-C*16:01:01:42Q differs from HLA-C*16:01:01:01 by one nucleotide substitution in the splicing site between intron 2 and exon 3.

Characterisation of the Novel HLA-DPB1*1783:01 Allele by Sequencing-Based Typing.

HLA-DPB1*1783:01 differs from HLA-DPB1*14:01:01:01 by one nucleotide substitution in codon 117 in exon 3.

Characterisation of the Novel HLA-A*68:322 Allele by Sequencing-Based Typing.

HLA-A*68:322 differs from HLA-A*68:45 by three nucleotide changes in exon 2.

Characterisation of the Novel HLA-A*32:01:64 Allele by Sequencing-Based Typing.

HLA-A*32:01:64 differs from HLA-A*32:01:01:01 by one nucleotide substitution in codon 56 in exon 2.

Characterisation of the Novel HLA-A*68:331 Allele by Sequencing-Based Typing.

HLA-A*68:331 differs from HLA-A*68:01:02:02 by one nucleotide substitution in codon 52 in exon 2.

Diagnosis, Characteristics, and Outcome of Selective Anti-polysaccharide Antibody Deficiencies In A Retrospective Cohort of 55 Adult Patients.

Selective anti-polysaccharide antibody deficiency (SPAD) predisposes to encapsulated bacterial infections. The diagnosis is challenging, and literature reports are scarce in adult patients, we therefore aim to describe the demographics, infectious complications, therapeutic strategies, and outcome of adult patients. We conducted a multicenter observational study involving 55 adult patients with SPAD.

Characterisation of the Novel HLA-DQB1*05:311:02 Allele by Sequencing-Based Typing.

HLA-DQB1*05:311:02 differs from HLA-DQB1*05:02:01:01 by one nucleotide substitution in codon 188 in Exon 3.

Characterisation of the Novel HLA-B*44:417 Allele by Sequencing-Based Typing.

HLA-B*44:417 differs from HLA-B*44:02:01:01 by one nucleotide substitution in codon -6 in exon 1.

Characterisation of the Novel HLA-B*35:627 Allele by Sequencing-Based Typing.

HLA-B*35:627 differs from HLA-B*35:01:01:01 by one nucleotide substitution in codon 80 in exon 2.

Characterisation of the Novel HLA-A*68:325 Allele by Sequencing-Based Typing.

HLA-A*68:325 differs from HLA-A*68:01:01:01 by one nucleotide substitution in codon -20 in exon 1.

Characterisation of the Novel HLA-DQA1*01:157 Allele by Sequencing-Based Typing.

HLA-DQA1*01:157 differs from HLA-DQA1*01:01:01:01 by one nucleotide substitution in codon 199 in exon 4.

Characterisation of the Novel HLA-A*01:471 Allele by Sequencing-Based Typing.

HLA-A*01:471 differs from HLA-A*01:01:01:01 by one nucleotide substitution in codon 250 in exon 4.

Characterisation of the Novel HLA-DQB1*05:355 Allele by Sequencing-Based Typing.

HLA-DQB1*05:355 differs from HLA-DQB1*05:01:01:01 by one nucleotide substitution in codon 197 in exon 4.

Characterisation of the Novel HLA-B*35:628 Allele by Sequencing-Based Typing.

HLA-B*35:628 differs from HLA-B*35:01:01:01 by one nucleotide substitution in codon 109 in exon 3.

Characterisation of the Novel HLA-C*05:01:83 Allele by Sequencing-Based Typing.

HLA-C*05:01:83 differs from HLA-C*05:01:01:01 by one nucleotide substitution in codon 291 in exon 5.

Characterisation of the Novel HLA-A*02:1198 Allele by Sequencing-Based Typing.

HLA-A*02:1198 differs from HLA-A*02:01:01:01 by one nucleotide substitution in codon -22 in exon 1.

Characterisation of the Novel HLA-B*38:121 Allele by Sequencing-Based Typing.

HLA-B*38:121 differs from HLA-B*38:01:01:01 by one nucleotide substitution in codon 106 in exon 3.

Characterisation of the Novel HLA-DRB1*13:01:44 Allele by Sequencing-Based Typing.

HLA-DRB1*13:01:44 differs from HLA-DRB1*13:01:01:01 by one nucleotide substitution in codon 180 in exon 3.