Effector-Memory γδ T Lymphocytes Predict CMV Disease After the Withdrawal of Prophylaxis in Kidney Transplant Recipients.

Evaluation of CMV-specific cell-mediated immunity (CMI) has improved strategies to prevent post-transplant CMV disease. This study assessed the association between CMV disease and absolute count of TEMRA γδ T cells at the end of universal prophylaxis in kidney transplant recipients (KTR). We retrospectively analyzed 262 R⁺ and 82 D⁺/R⁻ KTRs who received antiviral prophylaxis and had TEMRA γδ T cells quantified at the end of prophylaxis.

Deciphering the Interference of the Anti-Integrin α4β7 Vedolizumab With Cell Crossmatch.

In organ transplantation, immunological risk assessment uses cell crossmatch (XM) results, which can be altered by several drugs. We observed two recipients awaiting kidney and liver transplantation with positive flow cytometry XM (FCXM) on T-cells in the absence of Donor Specific Antibodies (DSA). Both were treated with vedolizumab (VDZ) for an inflammatory bowel disease (IBD).

Characterisation of the Novel HLA-DQB1*05:357 Allele by Sequencing-Based Typing.

HLA-DQB1*05:357 differs from HLA-DQB1*05:03:01:01 by one nucleotide substitution in codon 6 in exon 2.

Characterisation of the HLA-DPB1*104:01:08 Allele by Sequencing-Based Typing.

HLA-DPB1*104:01:08 differs from HLA-DPB1*104:01:01:04 by one nucleotide substitution in codon 199 in exon 4.

Characterisation of the Novel HLA-A*01:470 Allele by Sequencing-Based Typing.

HLA-A*01:470 differs from HLA-A*01:01:01:01 by one nucleotide substitution in codon 119 in exon 3.

Characterisation of the Novel HLA-DQA1*01:169 Allele by Sequencing-Based Typing.

HLA-DQA1*01:169 differs from HLA-DQA1*01:01:01:09 by one nucleotide substitution in codon 175 in exon 3.

Characterisation of the Novel HLA-C*07:1173 Allele by Sequencing-Based Typing.

HLA-C*07:1173 differs from HLA-C*07:02:01:03 by one nucleotide substitution in codon 96 in exon 3.

Characterisation of the Novel HLA-DQA1*01:170 by Sequencing-Based Typing.

HLA-DQA1*01:170 differs from HLA-DQA1*01:03:01:02 by one nucleotide substitution in codon 183 in exon 4.

Characterisation of the Novel HLA-DRB1*14:268 Allele by Sequencing-Based Typing.

HLA-DRB1*14:268 differs from HLA-DRB1*14:54:01:03 by one nucleotide substitution in codon 213 in exon 4.

Guidelines From the French-Speaking Society of Histocompatibility and Immunogenetics for Virtual Crossmatching for Deceased Donor Kidney Transplantation and the Use of Wet Crossmatch in the Decision-Making Process.

The systematic use of Single Antigen Flow Beads assays and the implementation of high-resolution HLA typing for donors and kidney transplant recipients allow a precise identification of anti-HLA donor-specific antibodies. In France, the availability of detailed molecular biology HLA typing for deceased donors in the national organ allocation software enables anticipation of wet crossmatch results and estimation of the immunological risk for a recipient/donor pair. This key process, named virtual crossmatching, involves a thorough analysis of the recipient's anti-HLA sensitisation records.

Characterisation of the Novel HLA-DRB1*11:340 Allele by Sequencing-Based Typing.

HLA-DRB1*11:340 differs from HLA-DRB1*11:01:01:01 by one nucleotide substitution in codon 36 in exon 2.

Characterisation of the Novel HLA-A*03:01:130 Allele by Sequencing-Based Typing.

HLA-A*03:01:130 differs from HLA-A*03:01:01:01 by one nucleotide substitution in codon 266 in exon 4.

Characterisation of the Novel HLA-A*32:01:59 Allele by Sequencing-Based Typing.

HLA-A*32:01:59 differs from HLA-A*32:01:01:01 by one nucleotide substitution in codon 303 in exon 5.

Characterisation of the Novel HLA-DPB1*04:02:27 Allele by Sequencing-Based Typing.

HLA-DPB1*04:02:27 differs from HLA-DPB1*04:02:01:01 by one nucleotide substitution in codon 193 in exon 4.

Characterisation of the Novel HLA-DQA1*01:67:02 Allele by Sequencing-Based Typing.

HLA-DQA1*01:67:02 differs from HLA-DQA1*01:67:01 by one nucleotide substitution in codon 229 in exon 4.

γδ T Cells' Role in Donor-Specific Antibody Generation: Insights From Transplant Recipients and Experimental Models.

The generation of donor-specific antibodies (DSA) requires that alloreactive B cells receive help from follicular helper T (T) cells. Recent works have suggested that γδ T cells could contribute to T cell-dependent humoral responses, leading us to investigate their role in DSA generation. Analysis of a cohort of 331 kidney transplant recipients found no relation between the number of circulating γδ T cells and the risk to develop DSA.

Characterisation of the Novel HLA-B*40:587 Allele by Sequencing-Based Typing.

HLA-B*40:587 differs from HLA-B*40:02:01:01 by one nucleotide substitution in codon 275 in exon 5.

Characterization of the Novel HLA-C*07:01:126 Allele by Sequencing-Based Typing.

HLA-C*07:01:126 differs from HLA-C*07:01:01:01 by one nucleotide substitution in codon 328 in exon 7.

Characterisation of the novel HLA-DPB1*1618:01 allele by sequencing-based typing.

HLA-DPB1*1618:01 differs from HLA-DPB1*18:01:01:01 by one nucleotide substitution in codon 215 in exon 4.

Characterisation of the novel HLA-DPA1*01:12:03 allele by sequencing-based typing.

HLA-DPA1*01:12:03 differs from HLA-DPA1*01:12:01 by one nucleotide substitution in codon 204 in exon 4.

Characterisation of the novel HLA-A*26:247 allele by sequencing-based typing.

HLA-A*26:247 differs from HLA-A*26:01:01:01 by one nucleotide substitution in codon 245 in exon 4.

Characterisation of the novel HLA-DRB1*08:126 allele by sequencing-based typing.

HLA-DRB1*08:126 differs from HLA-DRB1*08:04:01:01 by one nucleotide substitution in codon 152 in exon 3.