Handling objects with very wet skin reduce variability during precision grip task.

Several extrinsic factors affect precision grip task variability. Presence of moisture in glabrous skin can regulate the impact of extrinsic factors. Consequently, wetness may influence the precision grip task variability per se by regulating its force, rate and time parameters.

Time-Dependent Bidirectional Neuroprotection by Adenosine 2A Receptor in Experimental Traumatic Brain Injury.

Background: Traumatic brain injury (TBI) results in both focal and diffuse brain pathological features that become severely exacerbated after the initial injury. Owing to this disease complexity, no effective therapeutic measure has yet been devised aimed directly at these pathological processes. We developed a clinically relevant model of TBI and tested the bidirectional neuroprotective role of adenosine 2A receptors (A2ARs) at different times.

Cortical Aquaporin-4 in relation to brain oedema and neurological function of cortical cryo-injured mice.

To estimate the spatial and temporal expression of Aquaporin-4 (AQP-4) in a murine model of automated cerebral cryoinjury and correlate AQP-4 expression with development of brain oedema and neurological function. AQP-4 levels were determined quantitatively by Western blots at site of injury and at sites adjacent to and distant from injury in brains of cryoinjured (experimental) (n=18), sham injured (n=18) & normal mice at 24, 48, 72h post injury. AQP-4 expression was correlated with percentage water content of brain, Neurological Severity Score (NSS) and rotarod scores.

Surface electromyography activity in the upper limbs of patients following surgery for compressive cervical myelopathy.

Background: Surface electromyography (EMG) is a noninvasive, accurate method to measure electrical activity produced in muscles.

Aim: To assess the improvement of spasticity after decompressive surgery for compressive myelopathy using surface EMG.

Setting And Design: Neurophysiology laboratory of a tertiary care center.

Effect of pretreatment with a tyrosine kinase inhibitor (PP1) on brain oedema and neurological function in an automated cortical cryoinjury model in mice.

Cerebral oedema is a significant cause of morbidity in neurosurgical practice. To our knowledge, there is no ideal drug for prevention or treatment of brain oedema. Based on the current understanding of the pathogenesis of brain oedema, tyrosine kinase inhibitors could have a role in reducing brain oedema but preclinical studies are needed to assess their effectiveness.