Integrating Network Pharmacology and Molecular Docking Approach to Elucidate the Mechanism of for the Treatment of Rheumatoid Arthritis.

Background: Rheumatoid arthritis (RA) is considered a notable prolonged inflammatory condition with no proper cure. Synovial inflammation and synovial pannus are crucial in the onset of RA. The "tumor-like" invading proliferation of new arteries is a keynote of RA.

Better nanoscience through open, collaborative, and critical discussions.

We aim to foster a discussion of science correction and of how individual researchers can improve the quality and control of scientific production. This is crucial because although the maintenance of rigorous standards and the scrupulous control of research findings and methods are sometimes taken for granted, in practice, we are routinely confronted with articles that contain errors.

Impact of Ligands on Structural and Optical Properties of Ag Nanoclusters.

A ligand exchange strategy has been employed to understand the role of ligands on the structural and optical properties of atomically precise 29 atom silver nanoclusters (NCs). By ligand optimization, ∼44-fold quantum yield (QY) enhancement of Ag(BDT)(DHLA) NCs ( = 1-6) was achieved, where BDT and DHLA refer to 1,3-benzene-dithiol and dihydrolipoic acid, respectively. High-resolution mass spectrometry was used to monitor ligand exchange, and structures of the different NCs were obtained through density functional theory (DFT).

Assembly and Degradation of Inorganic Nanoparticles in Biological Environments.

In solution, nanoparticles may be conceptually compartmentalized into cores and engineered surface coatings. Recent advances allow for simple and accurate characterization of nanoparticle cores and surface shells. After introduction into a complex biological environment, adsorption of biological molecules to the nanoparticle surface as well as a loss of original surface components occur.