Unveiling phenolic content, antibacterial, and antibiofilm potential of sacha inchi ( L.) seed shell extracts against .

Sacha inchi (SI) seeds are renowned for their high oil content, with omega-3 and omega-6 polyunsaturated fatty acids accounting for approximately 85% of the total fatty acids. However, the use of seed by-products has not received much attention in research. The objective of the current study was to assess the antioxidant and antibacterial properties of aqueous and ethanolic extracts of SI seed shells.

Unveiling the therapeutic potential: anti-inflammatory and antioxidant properties of selective medicinal plants.

This study highlights the potential of plant extracts as sustainable and cost-effective alternatives to traditional anti-inflammatory drugs, owing to their rich bioactive compounds. The chemical composition and biological activities of ethanolic extracts from Artemisia campestris, Haloxylon articulatum, and Retama raetam were investigated. Extraction yields ranged from 2.

Correction: Biogenic sunflower oil-chitosan decorated fly ash nanocomposite film using white shrimp shell waste: Antibacterial and immunomodulatory potential.

[This corrects the article DOI: 10.1371/journal.pone.

Biogenic Synthesis of Photosensitive Magnesium Oxide Nanoparticles Using Citron Waste Peel Extract and Evaluation of Their Antibacterial and Anticarcinogenic Potential.

Background: Magnesium oxide nanoparticles (MgONPs) have been fabricated by several approaches, including green chemistry approach due to diverse application and versatile features.

Objectives: The current study aimed to prepare a convenient, biocompatible, and economically viable MgONPs using waste citron peel extract (CP-MgONPs) to evaluate their biological applications.

Methods: The CP-MgONPs were synthesized by a sustainable approach from extract of waste citron peel both as capping and reducing agents without use of any hazardous material.

Synthesis and characterization of polysiphonia/cerium oxide/nickel oxide nanocomposites for the removal of toxins from contaminated water and antibacterial potential.

Due to massive industrial development, organic and inorganic wastes are very common in most industrial effluents from the pharmaceutical industry. Even in low concentrations, they are very dangerous and harmful to humans and other living organisms. Antibiotics are frequently detected in surface waters, in soil, in wastewater from sewage treatment plants, and even in drinking water.

Silver nanoparticles improve the fungicidal properties of Rhazya stricta decne aqueous extract against plant pathogens.

One of the most promising, non-toxic, and biocompatible developments for many biological activities is the green synthesis of nanoparticles from plants. In this work, we investigated the antifungal activity of silver nanoparticles (AgNPs) biosynthesized from Rhazya stricta aqueous extract against several plant pathogenic fungi. UV-visible spectroscopy, Zeta potential analysis, Fourier-transform infrared spectroscopy (FTIR), and transmitted electron microscopy (TEM) were used to analyze the biosynthesized AgNPs.

Inhibition of hepatitis B virus activities by ‑derived acacetin and acetyl‑β‑carboline.

Hepatitis B virus (HBV) causes acute and chronic liver diseases, leading to cirrhosis and hepatocellular carcinoma. Although direct-acting nucleoside analogs, such as lamivudine (LAM), adefovir and famciclovir, are available, emergence of drug-resistance due to mutations in HBV polymerase (POL) restricts their further use. Alternatively, numerous plant products and compounds isolated from plants have been reported to confer anti-HBV efficacies without any sign of resistance or .

Impact of silver-doped alumina nanocomposite on water decontamination by remodeling of biogenic waste.

The main cause of various fatal diseases in humans and animals is environmental pollution. Ag-doped alumina nanocomposite was prepared using coffee husk extract with a large BET surface area of 126.58 m g and investigated for its antibacterial potential against both bacterial strains Escherichia coli and Salmonella typhimurium, and observed as an effective sorbent for removing the water pollution dye indigo carmine (IGC).

Biogenic sunflower oil-chitosan decorated fly ash nanocomposite film using white shrimp shell waste: Antibacterial and immunomodulatory potential.

A new sunflower oil-chitosan decorated fly ash (sunflower oil/FA-CSNPs) bionanocomposite film was synthesized using the extract of Litopenaeus vannamei (White shrimp) and evaluated as an antibacterial and immunomodulatory agent. Fly ash-chitosan nanoparticles were produced by using chitosan (CS) isolated from white shrimp extract, glacial acetic acid and sodium tripolyphosphate solution as cross-linkage. The ultrafine polymeric sunflower oil-CS film was fabricated by treating fly ash-chitosan nanoparticles with sunflower oil in glacial acetic acid under continuous stirring for 24 h.

Advanced polymeric metal/metal oxide bionanocomposite using seaweed extract for antiprotozoal, anticancer, and photocatalytic applications.

Background: Biosynthesized nanoparticles are gaining popularity due to their distinctive biological applications as well as bioactive secondary metabolites from natural products that contribute in green synthesis.

Methodology: This study reports a facile, ecofriendly, reliable, and cost-effective synthesis of silver nanoparticles (AgNPs), copper oxide nanoparticles (CuONPs), and polymeric PVP-silver-copper oxide nanocomposite using ethanol extract of seaweed and were evaluated for antiprotozoal, anticancer and photocatalytic potential. The nanostructures of the AgNPs, CuONPs, and polymeric PVP-Ag-CuO nanocomposite were confirmed by different spectroscopic and microscopic procedures.

Synergism between Extracts of Pericarp and in Ameliorating Altered Brain Neurotransmitters, Systemic Inflammation, and Leptin Levels in High-Fat Diet-Induced Obesity in Male Wistar Albino Rats.

This study aims to explore the effects of Garcinia mangostana (mangosteen) and Curcuma longa independently and synergistically in modulating induced inflammation and impaired brain neurotransmitters commonly observed in high-fat diet-induced obesity in rodent models. Male albino Wistar rats were divided into four experimental groups. Group I, control, obese, fed on a high-fat diet (HFD), and Group II-IV, fed on HFD then given mangosteen extract (400 mg/kg/day) and/or Curcuma (80 mg/kg/day), or a mixture of both for 6 weeks.

Grapefruit Extract-Mediated Fabrication of Photosensitive Aluminum Oxide Nanoparticle and Their Antioxidant and Anti-Inflammatory Potential.

Aluminum oxide nanoparticles (AlO NPs) were synthesized using a simple, eco-friendly green synthesis approach in an alkaline medium from the extract of grapefruit peel waste. The pre-synthesized, nano-crystalline AlO NPs were characterized by using spectroscopic (UV-vis, FTIR, XRD, and EDX) and microscopic (SEM and TEM) techniques. The formed AlO NPs exhibited a pronounced absorption peak at 278 nm in the UV-vis spectrum.

Anti-Hyperlipidemia, Hypoglycemic, and Hepatoprotective Impacts of Pearl Millet ( L.) Grains and Their Ethanol Extract on Rats Fed a High-Fat Diet.

This study tested the anti-hyperlipidemic, hypoglycemic, hepatoprotective, and anti-inflammatory effects of whole pearl millet grain powder (MPG) and its ethanol extract (MPGethaolE) in obese rats fed a high-fat diet. The rats were divided into eight groups based on the treatments they received: control, high fat diet (HFD), HFD + MGE (25 mg/Kg), HFD + MPGethaolE (50 mg/Kg), HFD + MPGethaolE (100 mg/Kg), HFD + MPG (10%), HFD + MPG (20%), and HFD + MPG (30%). The final body weight, visceral, epididymal fat pads, and the liver weight were significantly decreased, in a dose-dependent manner, in HFD fed rats that were co-administered either the MPG powder or MPGethaolE.

An approach unveils the potential of antiviral compounds in preclinical and clinical trials as SARS-CoV-2 omicron inhibitors.

The increased transmissibility and highly infectious nature of the new variant of concern (VOC) that is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron and lack of effective therapy need the rapid discovery of therapeutic antivirals against it. The present investigation aimed to identify antiviral compounds that would be effective against SARS-CoV-2 Omicron. In this study, molecular docking experiments were carried out using the recently reported experimental structure of omicron spike protein in complex with human angiotensin-converting enzyme 2 (ACE2) and various antivirals in preclinical and clinical trial studies.

Abubidentin A, New Oleanane-type Triterpene Ester from and its antioxidant, cholinesterase and antimicrobial activities.

Background: This work describes the phytochemical and biological investigation of aerial parts of Hochst. Of Saudi origin.

Methodology: Petroleum ether fraction of ethanolic extract was fractionated on a silica gel column and further purified with different chromatographic procedures for the isolation of chemical compounds.

Unprecedented Insights on Chemical and Biological Significance of Growing in Saudi Arabia.

Ehrenb ex Boiss. is a plant species reported from central Africa and the southern Arabian Peninsula, belonging to the family of Euphorbiaceae. The plant has ethnobotanical values and is well-known for its milky latex, which has been turned into medicine to treat various ailments.

The Fluorescence Detection of Phenolic Compounds in Extract Using Biosynthesized ZnO Nanoparticles and Their Biomedical Potential.

A facile, eco-friendly fluorescence approach based on the biogenic formation of zinc oxide nanoparticles using the biomass of shoots was developed. The suggested approach was employed to analyze three phenolic compounds (catechin, curviflorside, and curviflorin) isolated from the shoots of . The surface morphology of the prepared ZnONPs was characterized by carrying out different microscopic and spectroscopic investigations.

Immunomodulatory and Antioxidant Potential of Biogenic Functionalized Polymeric Nutmeg Oil/Polyurethane/ZnO Bionanocomposite.

The current study is focused on the biosynthesis of nutmeg oil/ polyurethane/ZnONPs bionanocomposite film for immunomodulatory and antioxidant activities. The fabricated film was prepared by using naturally extracted nutmeg oil functionalized with ZnONPs in the presence of polyutherane (PU) medium. The bionanocomposite film was obtained by incorporating dropwise 10 % (/) of nutmeg oil to the PU solution/ZnONPs blend.

Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Oil/TiO/Polyethylene Glycol Polymeric Bionanocomposite.

The present study is concerned with the fabrication of the bifunctional oil/TiO/polyethylene glycol polymeric film for antibacterial and anticancer activities. The suggested film is based on the utility of naturally extracted oil in the formation of the polymeric bionanocomposite film decorated with TiO nanoparticles. The bionanocomposite film was fabricated by incorporating 15 w% of oil with 10 w% polyethylene glycol and 5 w% TiO nanoparticles.

Metabolic profiling and biological activities of the aerial parts of Forssk. growing in Saudi Arabia.

The hydroalcoholic extract (MIT) of (Forssk.) growing in Saudi Arabia in addition to the chloroform (MIC) and -butanol (MIB) fractions were investigated for the first time using UPLC-ESI-MS/MS. The analysis revealed the tentative identification of fifty-eight compounds including three organic acids, twenty-five phenolic compounds, three coumarins, two anthocyanins, twenty-one flavonoids, three terpenes, and one miscellaneous.

Preparation, characterization, and in vitro-in silico biological activities of Jatropha pelargoniifolia extract loaded chitosan nanoparticles.

Jatropha pelargoniifolia (JP) is a medicinal plant that is widely used in traditional medicine owing to its broad range of therapeutic activities. Despite its promising pharmacological activities, the use of plant extracts has several limitations which can be overcome using pharmaceutical nanotechnology. The aim of this study was to systematically investigate the effect of nanoencapsulation on the antimicrobial and anticancer activities of JP extract.

The protective effect of plant extract against glutamate-induced DNA damage and reduced cell viability in a primary retinal ganglion cell line.

Background: Glutamate excitotoxicity can cause DNA damage and is linked to many retinal and neurological disorders. In mammals, the visual signal from the eyes to the brain is conducted only by retinal ganglion cells (RGCs), which can be damaged by overstimulation of glutamate receptors.

Methodology: We examined the protective effects of seed extract against glutamate-induced DNA damage in RGCs.

as candidate against excitotoxicity in retinal ganglion cells.

Unlabelled: Glutamate excitotoxicity is considered one of the major causes of retinal ganglion cell death in many retinal diseases. Retinal ganglion cell degeneration causes severe blindness since visual signals from the eye to the brain are conducted only through retinal ganglion cells.

Objective: We aimed to explore the potential ameliorative effects of against glutamate excitotoxicity-induced retinal ganglion cell damage.

Cytotoxic and anti-excitotoxic effects of selected plant and algal extracts using COMET and cell viability assays.

Excess glutamate in the central nervous system may be a major cause of neurodegenerative diseases with gradual loss and dysfunction of neurons. Primary or secondary metabolites from medicinal plants and algae show potential for treatment of glutamate-induced excitotoxicity. Three plant extracts were evaluated for impact on glutamate excitotoxicity-induced in primary cultures of retinal ganglion cells (RGC).