Synthetic Human Lactoferrin Peptide hLF(1-11) Shows Antifungal Activity and Synergism with Fluconazole and Anidulafungin Towards and Various Non-Albicans Species, Including .

Introduction: () has emerged globally, and diseases caused by it are associated with a mortality rate of 30-72%. This yeast is often multidrug-resistant and challenging to treat. A synthetic peptide, consisting of 11 amino acids of human lactoferrin (hLF1-11), offers a new therapy that is active against , non-albicans yeasts, as well as .

Phylogenetic diversity of species (Sordariomycetes, Glomerellales, Glomerellaceae) associated with plant diseases in Thailand.

is a cosmopolitan fungal genus, and its species are known for their important role as plant pathogens. They also occur as endophytes and saprobes. The genus comprises species complexes, many of which include cryptic species that are morphologically similar but phylogenetically distinct.

Three new species of (Hypocreales, Ophiocordycipitaceae) and a new host record for from China.

, a genus of invertebrate-pathogenic fungi in the family Ophiocordycipitaceae (order Hypocreales), is globally distributed. Over 300 species have been described and accepted as members of the genus. This study introduces three new species from China: , , and .

Pathogenic fungi (Sordariomycetes) associated with annual and perennial crops in Northern Thailand.

Phytopathogenic fungi induce severe diseases in plant hosts, potentially leading to significant crop quantity and quality reductions. In this study, we isolated and identified pathogenic fungi that threaten the successful cultivation of annual and perennial crops in northern Thailand. Samples with leaf spots, fruit rot, wilting, and dieback symptoms were collected from 19 different crops in Chiang Rai, Chiang Mai, and Sakon Nakhon provinces in Thailand.

Artificial neural network-based fungal chitin production for submicron-chitosan synthesis: effects on bioremediation for heavy metal pollution.

This study focused on optimizing fungal chitin (CT) production from a newly identified Fusarium incarnatum (GenBank: OL314753) for subsequent synthesis of submicron chitosan (sm-CS) tailored for enhanced heavy metal removal. Initial attempts to optimize CT yield using mixed nitrogen sources (potassium nitrate, peptone, yeast extract) via Box-Behnken Design (BBD) were insufficient for predicting optimal conditions. Consequently, Artificial Neural Networks (ANN) successfully modeled the BBD experimental data, the optimal nitrogen concentrations to 4.

Eco-friendly synthesis of Ag/CeO and CuO/CeO nanocomposites using extract and assessment of their antioxidant, antifungal, and cytotoxic activities.

This work focused on the biosynthesis of Ag/CeO and CuO/CeO nanocomposites (NCs) using extract. The nanocomposites were efficiently characterized using different techniques such as FTIR, UV-visible spectroscopy, zeta potential, DLS, TEM, SEM, EDX, and XRD analyses. The extract provided high phenolic and flavonoid contents, while demonstrating strong antioxidant action at IC = 0.

Wastewater remediation and enhanced energy harvesting by La-doped in rGO embedded with chitosan decorated gum rosin matrix.

This research presents the synthesis and application of a hybrid nanomaterial, Lanthanum (La) doped in reduced graphene oxide (rGO), embedded with a chitosan-decorated gum rosin (CS-GR) matrix mediated via pine tree, which is designed to address these dual challenges. The La-rGO/CS-GR nanomembrane (NMb) shows enhanced mechanical properties, with a tensile strength of 46 MPa at 4 wt% La-rGO doping, and achieves high adsorption efficiency for pollutants. The 4 wt% La-rGO/CS-GR: NMb demonstrated 85 % dye rejection efficiency for Congo red dye under filtration conditions, while also facilitating bio-electrochemical energy harvesting.

Unveiling Sordariomycetes taxa associated with woody litter in Northern Thailand.

Sordariomycetes species are abundant in woody litter samples. In this study, we introduce two novel species, (Diaporthaceae) and (Xylariaceae), from woody litter materials. We also describe a new host record of and a new geographical record for All collections were identified based on morphology and phylogenetic analyses of combined datasets.

Morphology and multi-gene phylogeny reveal three new species of and two combinations of (Bionectriaceae, Hypocreales) from Xizang, China.

and are genera in Bionectriaceae, and known in sexual perithecial ascomata and hyphomycetous asexual morphs. In their asexual morph, both genera share similar morphology in conidiophores and conidiogenous cell characteristics but differ in the development of conidiophores. The members of are distributed worldwide with the majority occurring in the tropics and the species are commonly reported as soil-borne fungi but also reported as endophytes, epiphytes, and saprotrophs.

Three new species of (Leotiomycetes, Helotiales) from Northern Thailand and Southwestern China.

is a discomycetous genus belonging to the family Helotiaceae (Helotiales). The genus currently comprises 19 species. Among them, 17 species have been reported from Asia, of which 14 were reported from China.

Unveiling four new taxa and comb. nov. in Stachybotryaceae (Hypocreales) from monocotyledon plants in Guangdong Province, China.

Members of Stachybotryaceae are distributed worldwide, with certain species playing a significant role as bio-degraders and some causing diseases in plants, humans, and animals. Other species within this family can be found in soil and have been reported as saprobes in various plants. In this study (2021-2022), fungal taxa resembling Stachybotryaceae, isolated from dead leaves of and a dead stem of in Guangdong Province, China, are identified based on morphological characteristics and molecular data.

Antimicrobial and cytotoxic activities of natural (Z)-13-docosenamide derived from .

Introduction: The synthesis of natural compounds with strong biological activity from affordable sources has proven challenging for scientists. As a natural resource rich in a variety of bioactive substances, fungal metabolites have the potential to be used in medical applications to serve a global purpose towards a sustainable future.

Methods: A total of 25 filamentous fungi were isolated, and their secondary metabolites were assessed for their antimicrobial efficiency.

Chemical, Physical, Microbial, and Sensory Properties of Innovative Sesame Milk Kefir, Focusing on the Ultrastructure of Kefir Grains.

The demand for innovative plant-based probiotic beverages is growing rapidly. This study aimed to develop and evaluate a novel kefir beverage using two types of sesame milk: permeate-based sesame milk (PSM) and water-based sesame milk (WSM). Chemical, physical, microbial, and sensory properties of kefir were assessed.

Characterization of Fungal Pathogens Causing Blueberry Fruit Rot Disease in China.

Blueberry has been a burgeoning fruit in China in recent years, but its perishable nature places a constant strain on industrial development. To determine the pathogens infecting blueberry fruits, diseased samples were collected from Guizhou and Fujian Provinces. Isolates from the samples were identified by morphological characterization and phylogenetic analyses.

Four new species of (Leotiomycetes, Helotiales) from southwestern China.

is found across various regions and is part of the family Lachnaceae (Helotiales). It is distinguished by its white to orange disc-shaped apothecia, white to brown receptacles, and granulated hairs that contain amorphous or resinous material. These hairs lack swelling apices and crystals.

Three novel species and a new record of Pleosporales (Didymellaceae, Roussoellaceae) from China.

We are investigating saprobic Ascomycota in Guizhou Province, China. Fungal specimens collected from dead wood were identified based on morphological characteristics and multi-gene phylogenetic analyses of ITS, SSU, LSU, , , and sequence data. Three novel species, , , and , are introduced, along with one new geographical record, .

Three new asexual species from Guizhou Province, China.

During our investigation of saprobic fungi in southwestern China, three micro-hyphomycetous fungi were isolated from dead wood in freshwater and terrestrial habitats in Guizhou Province. Phylogenetic analyses of ITS, LSU, and SSU sequences, performed using Maximum Likelihood and Bayesian Inference methods, confirmed that these isolates belong to . Based on distinct morphological characteristics and molecular phylogenetic evidence, we describe three new species: , , and .

Hexagonal zinc oxide nanoparticles: a novel approach to combat multidrug-resistant biofilms in feline urinary tract infections.

Introduction: , a common inhabitant of the feline gastrointestinal tract, has emerged as a significant pathogen causing urinary tract infections (UTIs) in domestic cats. The rise of multidrug-resistant strains and their propensity to form biofilms pose significant challenges in treatment. This study investigated the antibacterial and antibiofilm activities of hexagonal zinc oxide nanoparticles (ZnONPs) alone and in combination with streptomycin and Moringa oleifera leaf extract (MOLe) against multidrug-resistant isolates from feline UTIs.

Two novel hyphomycetes associated with ferns from China.

During an ongoing investigation of fungi associated with ferns in southwestern China, three hyphomycetes were discovered on the dead rachises of and an unidentified fern. Based on morphology and multi-gene phylogenetic analyses, and are introduced as new species. is a nematode-trapping fungus characterized by macronematous, mononematous, hyaline conidiophores, conidiogenous cells with polyblastic denticles at each node, and 0-1-septate, clavate to elongate pyriform, hyaline conidia.

Morpho-phylogenetic evidence reveals gen. et sp. nov. and gen. et sp. nov. in Chaetosphaeriaceae.

Anamorphic chaetosphaeriaceous fungi exhibit high morphological variability and are distributed worldwide across terrestrial and aquatic habitats. During an ongoing taxonomic study of microfungi, two intriguing chaetosphaeriaceous hyphomycetes were collected from dead wood and dead bamboo stems in China and Thailand. A polyphasic approach, combining morphological characteristics and phylogenetic analysis of LSU and ITS sequence data, revealed that these fungi represent two new genera within Chaetosphaeriaceae.

Metal Oxide Nanoparticles as Efficient Nanocarriers for Targeted Cancer Therapy: Addressing Chemotherapy-Induced Disabilities.

Cancer remains a predominant global health concern, necessitating effective treatment options. Conventional cancer therapies, particularly chemotherapy, often face constraints such as low selectivity, insufficient solubility, and multidrug resistance (MDR), which diminish effectiveness and exacerbate negative effects. Metal oxide nanoparticles (MONPs), such as iron oxide, zinc oxide, and copper oxide, offer a promising solution by enhancing targeted drug delivery, reducing systemic toxicity, and mitigating chemotherapy-induced disabilities like neurotoxicity and cardiotoxicity.

Comparative analysis of antifungal activity of Rhazya stricta ethanolic extracts and biogenic silver nanoparticles against pathogenic fungi.

Rhazya stricta, a perennial shrub native to the Middle East and South Asia, has been used in traditional medicine for various therapeutic purposes, including antimicrobial action. The current study aimed to compare the antifungal properties of 96% and 50% ethanolic extracts of R. stricta leaves and their biogenic silver nanoparticles (AgNPs).

A combined therapy of meropenem-ZnO nanoparticles efficiently eliminates carbapenem-resistant Klebsiella pneumoniae biofilms, with reduced nephrotoxicity (in vitro).

In response to the World Health Organization's research agenda of antimicrobial resistance in human health, this study appraised the antibacterial and antibiofilm synergistic activity of meropenem and ZnO nanoparticles (ZnO-NPs) combination against carbapenem-resistant Klebsiella pneumoniae (CRKP). The minimum inhibitory concentration (MIC) of meropenem in combination was found to be ~1/12 of its MIC alone. The results of microtiter dilution assay showed that the combination was more efficient in reducing the biofilm biomass than meropenem alone or ZnO-NPs alone.

(Microthyriaceae, Microthyriales), a new lignicolous freshwater fungi from a plateau lake in Yunnan Province, China.

Background: Based on unique morphological features and phylogenetic analysis of combined LSU and ITS sequences, is established as the third species in , along with and . All three species of were reported from freshwater habitats in China.

New Information: sp.