Role of metabolomic changes in diagnosis and assessment of treatment response in acute myeloid leukemia.

Acute Myeloid Leukemia (AML) is an aggressive cancer characterized by the rapid proliferation of abnormal myeloid cells. Despite advancements in treatment, patient outcomes remain variable, underscoring the need for more accurate diagnostic and prognostic tools. Metabolomics has gained attention for its potential to offer new insights into disease mechanisms and progression.

Is the curriculum of transfusion medicine in MBBS aligned with practical needs: A point of view of fresh graduates.

Objective: The objective of the study is to assess the satisfaction level of doctors regarding their competence in the blood transfusion process and their reflection on training at the undergraduate level.

Background: Transfusion errors due to suboptimal knowledge and lack of training can lead to grave outcomes. Therefore, to optimize patient care, a thorough understanding of transfusion medicine basics is highly imperative for all medical graduates.

Comparing Holotranscobalamin and Total Vitamin B12 in Diagnosing Vitamin B12 Deficiency in Megaloblastic Anemia Patients.

Background Megaloblastic anemia is characterized by abnormally large red blood cells caused by a deficiency in either vitamin B12 or folic acid, both of which are essential for DNA synthesis. Vitamin B12 insufficiency can lead to severe neurological damage, making early identification of vitamin B12 deficiency crucial to prevent irreversible harm. Vitamin B12 deficiency results in decreased levels of holotranscobalamin (Holo-TC) and increased levels of methylmalonic acid (MMA).

Bio-net dataset: AI-based diagnostic solutions using peripheral blood smear images.

Peripheral blood smear examination is one of the basic steps in the evaluation of different blood cells. It is a confirmatory step after an automated complete blood count analysis. Manual microscopy is time-consuming and requires professional laboratory expertise.

Comparison of thrombomodulin, vWF, and ADAMTS13 levels between preeclampsia and normal pregnancy.

Objectives: To determine and compare plasma thrombomodulin, von Willebrand factor and von Willebrand factorcleaving protease levels between pre-eclamptic and healthy pregnant females.

Methods: The cross-sectional, comparative study was conducted at the Department of Haematology, University of Health Sciences, Lahore, Pakistan, from November 2019 to December 2020, and comprised pregnant females who were divided into healthy pregnant group A and pre-eclamptic group B. Plasma thrombomodulin and von Willebrand factor-cleaving protease levels were determined by using commercially available enzyme-linked immunosorbent assay kit, and von Willebrand factor level was determined by using immuno-turbidimetric assay kit.

How Covid-19 literacy influences fear, protective behaviour, and conspiracy beliefs among university students in Pakistan?

Background: Covid-19 literacy, a social vaccine, is crucial to cope pandemic situations as it helps individuals to manage panic situations, adopt health preventive behaviours and adapting to the new normal.

Objectives: This research examined the effects of Covid-19 literacy on fear, protective behaviour, and conspiracy beliefs of university students using an online questionnaire.

Methods: A cross-sectional survey was conducted at two universities from Lahore with permission from concerned authorities.

How information literacy influences creative skills among medical students? The mediating role of lifelong learning.

This research investigated the influence of information literacy on the creative skills of medical students through the mediation of lifelong learning. A cross-sectional survey was conducted for data collection among medical students, recruited through a stratified convenient sampling procedure, of Khyber Pakhtunkhwa, Pakistan. The questionnaire was personally administered by visiting each college with written permission.

Information Literacy as a Predictor of Work Performance: The Mediating Role of Lifelong Learning and Creativity.

This study examined the effect of information literacy (IL) on work performance with mediating role of lifelong learning and creativity among journalists in Pakistan. A cross-sectional survey using an online questionnaire was conducted in the press clubs of four provinces (e.g.

Epidemiology, Clinico-Pathological Characteristics, and Comorbidities of SARS-CoV-2-Infected Pakistani Patients.

SARS-CoV-2 is a causative agent for COVID-19 disease, initially reported from Wuhan, China. The infected patients experienced mild to severe symptoms, resulting in several fatalities due to a weak understanding of its pathogenesis, which is the same even to date. This cross-sectional study has been designed on 452 symptomatic mild-to-moderate and severe/critical patients to understand the epidemiology and clinical characteristics of COVID-19 patients with their comorbidities and response to treatment.

Genetic Alterations, DNA Methylation, Alloantibodies and Phenotypic Heterogeneity in Type III von Willebrand Disease.

Type III von Willebrand disease is present in the Punjab province of Pakistan along with other inherited bleeding disorders like hemophilia. Cousin marriages are very common in Pakistan so genetic studies help to establish protocols for screening, especially at the antenatal level. Factors behind the phenotypic variation of the severity of bleeding in type III vWD are largely unknown.

Impact of Refractive Errors on the Academic Performance of High School Children of Lahore.

Introduction: The process of learning begins in childhood and accurate vision can greatly affects a child's learning capacity. It is documented that visual impairment in children can have a significant impact on their performance at school as well as their social interaction and development.

Objective: This research aimed to study the impact of refractive corrections on the academic performance of high school children in Lahore.

Health literacy predicts Covid-19 awareness and protective behaviours of university students.

Background: Health literacy is expected to help individuals deal with the required infection control and knowledge to cope with the COVID-19 pandemic.

Objectives: This study examined the impact of health literacy on Covid-19 awareness and protective behaviours of university students in Pakistan.

Methods: An online questionnaire was used to collect data from students at three universities in Punjab.

Wastage of Blood Units at Tertiary Care Hospitals of Lahore.

Introduction:  Blood and its products are the most valuable resource in every healthcare institution. Judicial use of these limited resources is necessary and important to maintain sufficient supply. Blood products and its transfusion system are being evaluated by the use of several markers.

Risk Stratification of Chronic Myeloid Leukemia According to Different Prognostic Scores.

Introduction Several prognostic indices are in use to stratify chronic myeloid leukemia (CML) patients: Sokal, Hasford, and the European Treatment and Outcome Study (EUTOS) being the most commonly reported ones. The application of different scores may cause variability in the determination of disease prognosis. This study was conducted to stratify patients of CML in accordance with Sokal, Hasford, and EUTOS scoring systems and to determine the concordance rate of risk categories, calculated by using all three scoring systems.

Myelofibrosis in Patients of Chronic Myeloid Leukemia in Chronic Phase at Presentation.

Objective: To determine the frequency and grading of myelofibrosis in patients of chronic myeloid leukaemia in chronic phase, and the association of cytopenias/cytosis with the degree of fibrosis.

Study Design: Descriptive study.

Place And Duration Of Study: King Edward Medical University, Lahore, from March 2015 to April 2017.