Serotonin Syndrome Masquerading as Alcohol Withdrawal: A Case Report.

Introduction: Alcohol withdrawal syndrome (AWS) and serotonin syndrome (SS) share several overlapping symptoms, complicating diagnosis in patients with alcohol use disorder (AUD) on serotonergic treatment.

Case Presentation: We describe a 54-year-old male with a history of AUD and anxiety disorder who presented to a residential treatment center after patient report about 11 days of alcohol abstinence. Despite an initially mild withdrawal course, he developed worsening tremors, nausea, diarrhea, diaphoresis, muscle twitching, rigidity, and restlessness beyond the typical AWS timeframe.

Sustained Delivery of Dolutegravir Sodium for Better Management of HIV/AIDS via Solid Lipid Nanoparticles.

Introduction: Human immunodeficiency virus (HIV) is a primary health concern that leads to Acquired immunodeficiency syndrome (AIDS), with more than 39.9 million people living with HIV globally. Dolutegravir sodium is a lipophilic compound with a log P value of 2.

Identification of IGFBP2 gene polymorphism and association of genotypes with performance traits in Large White Yorkshire pigs.

Pig promises distinct qualities like early maturity, high fecundity, produces piglets between eight to twelve in each farrowing and high feed conversion efficiency that make piggery a low-cost profitable enterprise. The objective of this study was to evaluate the genetic diversity in Large White Yorkshire pigs based on variations in Insulin like growth factor binding protein 2 (IGFBP2) gene which is involved in regulation of embryonic development and association of variants with economic traits. Blood samples were collected from 100 pigs and polymorphism was explored in IGFBP2 gene using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique.

Responding to drug-related harm among South Asian populations in Canada.

The impact of the toxic drug crisis on South Asian people is under-researched. This rapidly growing population faces unique sociocultural challenges related to substance use. This includes psychosocial stress associated with acculturation, which may lead to illegal drug use as a coping mechanism.

Digital Transformation of Healthcare Access: A Comparative Time Series Analysis of Online Versus Conventional OPD Registrations at a Tertiary Care Hospital.

Introduction: The Ayushman Bharat Digital Mission (ABDM) is transforming India's healthcare through digitization, including online outpatient department (OPD) registration using Ayushman Bharat Health Account (ABHA) identities (IDs). With an increase in the number of ABHA accounts, understanding time requirements and bottlenecks in these digital workflows is crucial for successful implementation.

Primary Objective: To evaluate the efficiency of patient registration by measuring and comparing the time taken for each step in the online registration and conventional offline OPD registration.

I-SIRch: AI-powered concept annotation tool for equitable extraction and analysis of safety insights from maternity investigations.

Background: Maternity care is a complex system involving treatments and interactions between patients, healthcare providers, and the care environment. To enhance patient safety and outcomes, it is crucial to understand the human factors (e.g.

Assessment of age using physiological methods: dentin deposition versus tooth wear: A cross-sectional study.

Age is a crucial factor in identifying a person in forensic medicine. Dentition is one of the physiological indicators of chronological age. Radiographic dental age assessment is a simple, noninvasive and reproducible method.

Tongue print as a valuable biometric and forensic tool: A digital photographic study.

Background: Surface features present on the dorsal surface of the tongue along with colour and shape are unique characteristics of every individual. Tongue print is being considered as a new biometric and forensic authentication tool. This digital photographic study was conducted to analyze and compare morphological differences on the dorsal surface of the tongue which can serve as a valuable tool in forensic odontology.

Predicting unicompartmental arthroplasty success: a three year Indian study.

Purpose: This study evaluated the three year clinical outcomes and predictors of success for unicompartmental knee arthroplasty (UKA) in an Indian population.

Methods: Twenty patients with medial compartment osteoarthritis (≥ Ahlbäck grade 2) underwent UKA. American Knee Society Score (AKSS), Oxford Knee Score (OKS), and Visual Analogue Scale Score (VAS) were assessed at baseline, two weeks, six weeks, three months, and three years.

Deactivated fused silica tubing: A solution for flexible time weighted averaging needle trap sampling.

In time-weighted averaging (TWA) with needle trap extraction (NTE), the control of the sampling rate is critical for accurate analysis. By adjusting the diffusion length and cross-sectional area, the sampling rate can be modified in accordance with Fick's first law of diffusion. In this study, deactivated fused silica tubing (DFST) of varying lengths was used to fine-tune these parameters, allowing for precise control of the sampling rate in TWA-NTE devices.

Meta-Analysis of Prognostic Significance of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma.

Objective: Researchers have shown significant interest in cancer stem cells in recent years. CD44, CD24, CD133, and ALDH serve as indicators of cancer stem cell-like cells in Oral Squamous Cell Carcinoma. However, the prognostic significance of these Cancer Stem Cell markers in Squamous Cell Carcinoma is still debated.

Color Tunable Three Terminal (3-T) Vertically Stacked Tandem Organic Electroluminescent Devices.

Traditional full-color displays typically use a pixel layout with three side-by-side subpixels emitting red (R), green (G), and blue (B) colors. However, this configuration limits the resolution especially in augmented reality (AR) and virtual reality (VR) applications. To address the issue of low pixel density in display technology, this study demonstrated vertically stacked three-terminal (3-T) bottom-emitting tandem OLEDs (sOLED).

Evaluation of Emerging Predictors for Contrast-Induced Nephropathy in High-Risk Patients Undergoing Percutaneous Coronary Intervention.

Objective: The objective of this study is to investigate the occurrence and factors that influence the development of contrast-induced nephropathy (CIN) in high-risk patients undergoing angioplasty and to evaluate the effectiveness of the Mehran risk score in predicting CIN among this patient population.

Materials And Method: This prospective, observational study enrolled patients undergoing elective coronary angiography or a percutaneous coronary intervention (PCI) procedure. The patients were stratified into four risk groups based on the Mehran risk score, a validated tool for predicting the risk of CIN.

Taking the Road Less Travelled: A Case Report of Distal Splenic Artery Embolisation via the Pancreaticoduodenal Arcade in Splenic Trauma With Celiac Artery Stenosis.

Celiac axis stenosis (CAS) is one of the most prevalent splanchnic arterial pathologies. It seldom results in clinically severe ischemic bowel disease because of the rich collateral circulation from the superior mesenteric artery. Knowledge about the collaterals in celiac artery stenosis guides various interventional procedures.

Variations in origin level of superior mesenteric artery, inferior mesenteric artery, and coeliac trunk in Indian population.

Objective: The abdominal aorta is a continuation of the thoracic aorta and gives off the coeliac trunk, superior mesenteric artery, and inferior mesenteric artery. The focus of our study is to evaluate variations in the origin level in the coeliac trunk, superior mesenteric artery, inferior mesenteric artery, and aortic bifurcation in the Indian population and compare with various demographics.

Methods: The study was retrospective and the local ethics committee approval was taken before starting it.

Leveraging neuroscience education to address stigma related to opioid use disorder in the community: a pilot study.

Opioid use disorder (OUD) and overdose deaths are a public health crisis. One contributing factor is stigma towards people who use opioids. We developed and conducted a public-facing, half-day educational event designed to challenge misperceptions about OUD from a contemporary neuroscience perspective.

Leveraging neuroscience education to address stigma related to opioid use disorder (OUD) in the community: A pilot study.

Opioid use disorder (OUD) and overdose deaths are a public health crisis. One contributing factor is stigma towards people who use opioids. We developed and conducted a public-facing, half-day educational event designed to challenge misperceptions about OUD from a contemporary neuroscience perspective.

Cholic Acid-Derived Gemini Amphiphile Can Eradicate Interkingdom Polymicrobial Biofilms and Wound Infections.

Biofilm infections are mainly caused by Gram-positive bacteria (GPB) like , Gram-negative bacteria (GNB) like , and fungi like . These infections are responsible for antimicrobial tolerance, and commensal interactions of these microbes pose a severe threat to chronic infections. Treatment therapies against biofilm infections are limited to eradicating only 20-30% of infections.

Groundwater quality index development using the ANN model of Delhi Metropolitan City, India.

Groundwater is widely recognized as a vital source of fresh drinking water worldwide. However, the rapid, unregulated population growth and increased industrialization, coupled with a rise in human activities, have significantly harmed the quality of groundwater. Changes in the local topography and drainage systems in an area have negative impacts on both the quality and quantity of groundwater.

Network-wide safety impacts of dedicated lanes for connected and autonomous vehicles.

Cooperative, Connected and Automated Mobility (CCAM) enabled by Connected and Autonomous Vehicles (CAVs) has potential to change future transport systems. The findings from previous studies suggest that these technologies will improve traffic flow, reduce travel time and delays. Furthermore, these CAVs will be safer compared to existing vehicles.

infection of the wrist joint: A current concepts review.

Background: Osteoarticular Tuberculosis (TB) of wrist joint is a rare, often misdiagnosed form of site affected by infection that can lead to severe disability and morbidity. This review aims to summarize the current literature on the diagnosis and management of infection of the wrist joint.

Materials And Methods: A comprehensive search strategy using the PEO (Population, Exposure, Outcome) framework was conducted on PubMed, Google Scholar, and Web of Science databases from 1967 to 2022, excluding single case reports and correspondence articles.

Association of sagittal alignment of tibial and femoral components with clinical outcome in total knee arthroplasty: A prospective cohort study.

Background: In total knee replacement component alignment is a very crucial parameter to achieve better clinical outcomes. Only a few studies exist in the literature on the association between sagittal alignment of components and clinical outcomes. The study aimed to measure the functional outcome and association between the sagittal alignment of total knee replacement components and their clinical outcome.