Bioactivity of novel isoxazole-fused heterocycles: comprehensive antimicrobial, antioxidant activities, SwissADME predictions, molecular docking, and DFT analysis.

Among the foremost goals for organic chemists is to discover novel approaches for the synthesis of a particular heterocyclic and its design. Our approach focused on the vital precursor 4-acetyl-3-phenylisoxazol-5(4H)-one 3, as this molecule has an endocyclic carbonyl function in position 5 adjacent to the substituted acetyl function at site 4. Therefore, compound 3 was a crucial component of many types of fused isoxazole.

Optimized Congo Red Dye Adsorption Using ZnCuCr-Based MOF for Sustainable Wastewater Treatment.

This study presents the synthesis of a novel trimetallic ZnCuCr-TpIm metal-organic framework (MOF) via a solvothermal method, yielding cubic crystals of 300-500 nm. The integration of Zn, Cu, and Cr metal centers enhances the MOF's adsorption efficiency and structural stability, distinguishing it from conventional MOFs. The material achieves a high Congo red dye removal efficiency (96.