Publications by authors named "Miriana Migliaccio"
Article Synopsis
- The study aimed to estimate the prevalence and incidence of dementia and Alzheimer's disease (AD) in the Campania region of South Italy, using healthcare data from 2015 to 2020.
- Researchers analyzed data from individuals aged 65 and older and found that 80,392 had dementia, with a prevalence rate of 77.64 per 1,000 for any dementia and 34.05 per 1,000 for AD.
- The incidence rates were 82.10 cases of dementia and 59.89 cases of AD per 100,000 people annually, and the performance of their algorithms for detecting dementia was validated against clinical tests with good sensitivity and specificity.
Article Synopsis
- SPG18 is linked to mutations in the ERLIN2 gene, with autosomal recessive mutations often leading to complicated hereditary spastic paraplegia and autosomal dominant mutations resulting in a pure form of the disease.
- The study aimed to explore the varying clinical presentations of SPG18 and assess if a dominant negative effect of the V168M mutation in ERLIN2 contributes to differences between AR and AD phenotypes.
- Results revealed a family showing diverse symptoms across generations, including amyotrophic lateral sclerosis and pure hereditary spastic paraplegia, while the V168M mutation did not seem to affect the oligomerization of erlin2, highlighting the complexity of SPG18 and the necessity for thorough clinical assessments.
Tool-use skills represent a significant cognitive leap in human evolution, playing a crucial role in the emergence of complex technologies. Yet, the neural mechanisms underlying such capabilities are still debated. Here we explore with fMRI the functional brain networks involved in tool-related action understanding.
View Article and Find Full Text PDFThe "Little Circles Test" (LCT): a dusted-off tool for assessing fine visuomotor function.
Aging Clin Exp Res
November 2023
Background: The fine visuomotor function is commonly impaired in several neurological conditions. However, there is a scarcity of reliable neuropsychological tools to assess such a critical domain.
Aims: The aim of this study is to explore the psychometric properties and provide normative data for the Visual-Motor Speed and Precision Test (VMSPT).
Neurofeedback (NF) is a biofeedback technique that teaches individuals self-control of brain functions by measuring brain activations and providing an online feedback signal to modify emotional, cognitive, and behavioral functions. NF approaches typically rely on a single modality, such as electroencephalography (EEG-NF) or a brain imaging technique, such as functional magnetic resonance imaging (fMRI-NF). The introduction of simultaneous EEG-fMRI tools has opened up the possibility of combining the high temporal resolution of EEG with the high spatial resolution of fMRI, thereby increasing the accuracy of NF.
View Article and Find Full Text PDFObjective: To evaluate the relation between retinal vascular impairment and cognitive decline in patients with amnestic mild cognitive impairment (aMCI) over time.
Methods: Spectral domain-optical coherence tomography (SD-OCT) and OCT angiography study was performed in aMCI patients over 2 years follow-up and compared to baseline.
Results: Thirty-eight eyes from 19 aMCI patients were evaluated.