Research on the impact of spatial and temporal changes in ecological product value in Hebei Province based on land use changes.

Analyze the changes in land use and the spatial evolution characteristics of ecological product value in Hebei Province, understand the driving factors that affect the value of ecological products, and aim to promote the sustainable use of land resources and promote local economic development. This paper investigated the changes in land use and landscape patterns in Hebei Province from 2010 to 2022, and used the improved equivalent factor to account for the value of ecological products, used the global Moran's I index, high/low clustering index,and the hotspot analysis method to explore the characteristics of spatial and temporal changes in the value of ecosystem services in different districts and counties of the study area, and finally used geodetector to explore the influence factors of land use change on the spatial and temporal changes in the value of ecological products in Hebei Province. value of ecological products in Hebei Province.

Thiourea modified low molecular polyamide as a novel room temperature curing agent for epoxy resin.

A thiourea modified low molecular weight polyamide (TLMPA) as a room temperature curing agent was synthesized by a two-step method. Firstly, a low molecular weight polyamide curing agent (LMPA) with low viscosity and high amine value was synthesized by amidation of sebacic acid with tetraethylenepentamine, then the synthesized curing agent was modified with thiourea to increase its reactivity at room temperature. The optimal reaction conditions were studied by L(3) orthogonal experiments.

Reactive Molecular Dynamics Calculation and Ignition Delay Test of the Mixture of an Additive and 2-Azido-,-dimethylethanamine with Dinitrogen Tetroxide.

In order to shorten the ignition delay of 2-azido-,-dimethylethanamine (DMAZ) and dinitrogen tetroxide (NTO), four amines [-butylamine, pyrrole, ,,','-tetramethyl ethylenediamine (TMEDA), and diethylenetriamine (DABH)] with a mass fraction of 5% were added to DMAZ, and the potential energy change and the product change during the reaction of the mixture of an additive and DMAZ with NTO were analyzed by Reactive molecular dynamics (ReaxFF MD) calculation. Then, the ignition delay of the mixture of the additive and DMAZ as well as pure DMAZ with NTO was measured by a drop experiment with a photoelectric sensor and high-speed camera. The results show that the addition of pyrrole greatly reduced the time to reach the maximum system energy and greatly increased the rate of HNO formation.

Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice.

Autophagosome accumulation is observed in the distal axons of Alzheimer disease (AD) patients and AD animal models, suggesting that deficient retrograde transport and impaired autophagic clearance of beta-amyloid (A β) contribute to AD pathogenesis. Expression of the retrograde axonal transport-related protein dynein intermediate chain (DIC) is also reduced in AD patients, but the contributions of DIC to AD pathology remain elusive. This study investigated the effects of DIC expression levels on cognitive function, autophagosome axonal transport, and A β clearance in the APP/PS1 double transgenic mouse model of AD.

Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells.

The accumulation of autophagosomes and dysfunction at the axonal terminal of neurons play crucial roles in the genesis and development of Alzheimer's disease (AD). Abnormalities in neuron axonal transport-related proteins prevent autophagosome maturation in AD. Curcumin, a polyphenol plant compound, has been shown to exert neuroprotective effects by increasing autophagy in AD, but the underlying mechanism of its effect on autophagy axon transport remains elusive.

Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury.

Microglia-mediated inflammation is an important step in the progression of cerebral ischemia/reperfusion injury and the associated production of receptors of immunomoudulation, including Toll-like receptors (TLRs). Peroxiredoxin 6 (Prdx6) has been demonstrated as the endogenous antioxidant protein for its peroxidase properties. However, the role of the independent phospholipase A2 (iPLA2) activity of Prdx6 in stroke has not been well studied.

Expression analysis and clinical significance of eIF4E, VEGF-C, E-cadherin and MMP-2 in colorectal adenocarcinoma.

The underlying mechanisms of colorectal carcinoma (CRC) metastasis remain to be elucidated. The aim of this study is to investigate clinical significance and the expression of eIF4E, VEGF-C, MMP-2, and E-cadherin in the CRC metastasis. We investigated their expressions in 108 patients, analyzed the relationships between their expressions in CRC and evaluated the relationships between their expressions and clinical pathogenic parameters.