E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin-dependent receptor-interacting protein kinase 3 (RIP3) degradation.

Background And Purpose: Severe acute pancreatitis (SAP) is a critical abdominal condition with high mortality rates. The activation of necroptosis in acinar cells is an critical mechanism for SAP. Pellino1 (PELI1), as an E3 ubiquitin ligase, is involved in pathogenic mechanisms in various diseases.

Leonurine Attenuates CCl-Induced Hepatic Fibrosis in Mice via the Hippo-YAP Pathway.

Background And Purpose: The repair response to persistent damage in the liver manifests as liver fibrosis. Leonurine (Leo), an herbal remedy from traditional Chinese medicine, exhibits multiple biological activities such as antioxidant and anti-inflammatory effects. Nevertheless, research exploring Leo's influence on liver fibrosis remains absent.

Daidzein alleviates CCl- and BDL-induced liver fibrosis suppressing the integrin alphaVbeta1/YAP signaling.

Liver fibrosis is a pathological process characterized by the excessive deposition of diffuse extracellular matrix in the liver, serving as a reparative response of the body to chronic liver injury. Daidzein (DAI) is an isoflavone compound primarily derived from leguminous plants, such as soybeans and kudzu root. Numerous studies have demonstrated its significant anti-inflammatory and antioxidant properties; however, the extent of its role in anti-hepatic fibrosis remains uncertain.

Molecular Structure Regulation Elicits Steric Hindrance of Ketone Additives with High Adsorbability for Oriented Deposition of Zn Anode.

The uncontrollable dendritic growth and interfacial parasitic reactions severely hinder the large-scale operation of aqueous zinc-ion batteries (AZIBs), root in the fundamental kinetics imbalance between the excessively rapid electrochemical reduction rate and retarded bulk mass transfer. To resolve this dilemma, a rationally structure-designed ketone additive, butane-2,3-dione (BD), was screened from a series of counterparts to achieve highly reversible Zn plating/stripping by moderating electroreduction kinetics. Specifically, the BD molecule preferentially adsorbs in the inner Helmholtz plane to repel solvated Zn-ions via the steric-hindrance effect.

Insight into the Catalytic Nature of Lithiophilicity for High-Energy-Density Lithium Metal Batteries.

Designing dendrite-free lithium (Li) metal anodes for high-performance batteries requires a fundamental understanding of the substrate's lithiophilicity. Here, we systematically explore the electrochemical nucleation behavior of Li on various transition-metal substrates and uncover a substrate-dependent nucleation barrier that follows an inverted volcano-shaped curve, determined by the d-band center (ε) of these metals. Density functional theory calculations reveal that an optimal ε balances Li-atom adsorption and migration during Li nucleation, minimizing the nucleation barrier.

Cation-Trapping Engineering Tailors Bismuth Selenide to Enable Superior Multivalent Ion Storage via an Optimized Synergistic Dual-Reaction Mechanism.

Aqueous multivalent-ion batteries have garnered considerable attention as a promising alternative to lithium-ion batteries, offering advantages such as low cost, high specific capacity, enhanced safety, and environmental sustainability. However, the development of efficient cathodes remains challenging, constrained by sluggish multivalent-ion diffusion and pronounced structural degradation. Here, we introduce cation-trapping engineering to tailor the topological insulator BiSe (ZnBiSe), enhancing the electrochemical performance by activating additional active sites and expanding the interlayer spacing.

Visual Engineering Achieved with Electronegative Carbon Dots for Highly Efficient Ion Flux Regulation.

Various modification methods for lithium-metal battery separators have been well explored in the past decades, among which the most common process is to coat modified slurries onto the separators by blade-coating method. However, the distribution of the slurries is often non-uniform in this process, while the uniformity usually needs to be detected by electron microscope, which is time and cost-consuming. To solve this long-standing technical issue, it focuses on the "visualization" of modification effect with negatively charged carbon dots under UV light, and deeply investigates the ion transport problem caused by the non-uniform material modification.

Catalytic synergism in heterostructural Ta-doped Mo-Ni-S nanospheres: an efficient bifunctional catalyst for water splitting.

Designing suitable and efficient electrocatalysts for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is crucial for sustainable hydrogen production. To date, extensive studies have focused on transition metal chalcogenides (TMSs) due to their unique electronic structure and strong ability to be modified. Herein, we reported a Ta-doped MoS/NiS catalyst supported on NF with a stable hierarchical nanosphere structure (Ta-MNS).

Eco-Friendly High-Performance Symmetric All-COF/Graphene Aqueous Zinc-Ion Batteries.

Developing high-performance aqueous symmetric all-organic batteries (SAOBs) by replacing metal-based batteries or batteries with organic electrolytes is highly attractive to achieve a greener rechargeable world. However, such a new energy storage system still exhibits unsatisfactory rate capability and cycling stability due to the limitations in electrode materials screening. Here, a novel covalent organic framework (COF) containing abundant CN and CO for the electrode material is designed, which is combined with graphene and assembled into all-COF/graphene batteries for the first time.

Zincophilic host with lattice plane matching enables stable zinc anodes in aqueous zinc-ion batteries.

The practical application of aqueous zinc-ion batteries (AZBs) as attractive energy storage devices is severely hampered by the uncontrollable zinc dendrite growth on the metal anode. Here, a lightweight and flexible free-standing membrane of MXene/Ag nanowires (AgNWs) was synthesized via vacuum filtration to support the zinc anode. The 3D cross-linked network structure provides ample space for densely packed zinc electrodeposition.

A gel polymer electrolyte functionalized separator for high-performance lithium-sulfur batteries.

Lithium-sulfur (Li-S) batteries, featuring ultrahigh specific theoretical energy density with low-cost raw materials, have been deemed one of the most promising candidates for next-generation energy storage and conversion devices. However, the shuttle effect of soluble Li polysulfides (LiPSs) has seriously hindered their practical deployment. Herein, we report that tris(pentafluorophenyl)borane (TPFPB) is used to modify the separator (TPFPB/AlO) for suppressing the shuttle effect of LiPSs.

The impact of various antiplatelet strategies on the incidence of gouty arthritis in hospitalized patients with acute cerebral infarction.

Objectives: 1.To explore the incidence of concurrent gouty arthritis (GA) during hospitalization in patients with different subtypes of acute stroke. 2.

Scalable Customization of Crystallographic Plane Controllable Lithium Metal Anodes for Ultralong-Lasting Lithium Metal Batteries.

A formidable challenge to achieve the practical applications of rechargeable lithium (Li) metal batteries (RLMBs) is to suppress the uncontrollable growth of Li dendrites. One of the most effective solutions is to fabricate Li metal anodes with specific crystal plane, but still lack of a simple and high-efficient approach. Herein, a facile and controllable way for the scalable customization of polished Li metal anodes with highly preferred (110) and (200) crystallographic orientation (donating as polished Li(110) and polished Li(200), respectively) by regulating the times of accumulative roll bonding, is reported.

Anion-Immobilized Gel Polymer Electrolyte with a High Ion Transference Number for High-Performance Lithium/Sodium Metal Batteries.

Due to their high energy density, lithium/sodium metal batteries (LMBs/SMBs) are expected to be the next generation of energy storage systems. However, the further application of alkali metal batteries based on liquid electrolytes is limited due to increasing safety concerns. Gel polymer electrolytes (GPEs), which combine the advantages of the high ionic conductivity of liquid electrolytes and excellent mechanical properties of solid polymer electrolytes, are considered to play an irreplaceable role in the realization of high-performance alkali metal batteries.

Aloin Attenuates Oxidative Stress, Inflammation, and CCl-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.

Liver fibrosis refers to the excessive buildup of extracellular matrix (ECM) components in liver tissue. It is considered a pathological response to liver damage for which there is no effective treatment. Aloin, an anthraquinone compound isolated from the aloe plant, has shown good pharmacological effects in the treatment of gastric cancer, ulcerative colitis, myocardial hypertrophy, traumatic brain injury, and other diseases; however, its specific impact on liver fibrosis remains unclear.

Hierarchical Ohmic Contact Interface Engineering for Efficient Hydrazine-Assisted Hydrogen Evolution Reaction.

Hydrazine oxidation reaction coupled with hydrogen evolution reaction (HER) is an effective strategy to achieve low energy water splitting for hydrogen production. In order to realize the application of hydrazine-assisted HER system, researchers have been focusing on the development of electrocatalysts with integrated dual active sites, while the performance under high current density is still unsatisfying. In this work, hierarchical Ohmic contact interface engineering is designed and used as a bridge between the NiMo and Ni P heterojunction toward industrial current density applications, with the charge transfer impedance greatly eliminated via such a pathway with low energy barrier.

Plant Transpiration-Inspired Biomass-Based Device with Underwater Oleophobicity for Efficient General-Purpose Solar-Driven Oily Wastewater Purification.

The remediation of wastewater containing oily pollutants is imperative to mitigate the serious threats posed to the safety of fresh water, human well-being, and the environment. Current membrane separation technologies are severely restricted by their limitations for separating various types of oily pollutants with low sustainability. Herein, by imitating the plant transpiration in nature, we designed a solar-driven device composed of natural biomass sugar cane stem, chitosan/carboxymethyl cellulose, and graphite powders to separate versatile oily pollutants from the wastewater.

Giant teratoma with isolated intestinal duplication in adult: A case report and review of literature.

Background: A combination of diseases is a rare phenomenon. Their clinical manifestations can vary, and the diagnosis can be challenging. Intestinal duplication is a rare congenital malformation, whereas retroperitoneal teratoma is a tumor in the retroperitoneal space, derived from the remaining embryonic tissue.

Potential Antioxidative Activity of Homocysteine in Erythrocytes under Oxidative Stress.

Homocysteine is an amino acid containing a free sulfhydryl group, making it probably contribute to the antioxidative capacity in the body. We recently found that plasma total homocysteine (total-Hcy) concentration increased with time when whole blood samples were kept at room temperature. The present study was to elucidate how increased plasma total-Hcy is produced and explore the potential physiological role of homocysteine.

Liquid Metal-Tailored PEDOT:PSS for Noncontact Flexible Electronics with High Spatial Resolution.

Electric field-based noncontact flexible electronics (EF-NFEs) allow people to communicate with intelligent devices through noncontact human-machine interactions, but current EF-NFEs with limited detections (usually <20 cm) distance often lack a high spatial resolution. Here, we report a versatile material for preparing EF-NFE devices with a high spatial resolution to realize everyday human activity detection. Eutectic gallium-indium alloy (EGaIn) was introduced into poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) chains to fabricate this material, named Ga-PP.

Risk factors associated with radiolucent foreign body inhalation in adults: a 10-year retrospective cohort study.

Background: Foreign body aspiration (FBA) is a serious condition with high morbidity and mortality rates. Although chest radiography is generally the first radiologic modality used in diagnosis, a substantial percentage of foreign bodies are radiolucent in adults with diagnosis challenging.

Methods: Retrospective review of adult patients with FBA diagnosed by flexible electronic bronchoscopy from 2012 to 2022 collecting demographics, history, hospital presentation, radiographic, and operative details.

Nanoconfined Space: Revisiting the Charge Storage Mechanism of Electric Double Layer Capacitors.

The electric double layer capacitor (EDLC) has been recognized as one of the most appealing electrochemical energy storage devices. Nanoporous materials with relatively high specific surface areas are generally used as the electrode materials for electric double layer capacitors (EDLCs). The past decades have witnessed anomalous phenomena of EDLCs under nanoconfined space, which to a large degree doubt the conventional recognition.

Deciphering the role of LiNO additives in Li-S batteries.

The ultrahigh theoretical energy density of lithium-sulfur (Li-S) batteries has attracted intensive research interest. However, most of the long-term cycling performance parameters are strongly dependent on the utilization of the electrolyte, which is considered as an indispensable component in Li-S batteries. Over the past few decades, numerous research studies around LiNO as an electrolyte additive have been carried out and have been confirmed to significantly upgrade the electrochemical performance of Li-S batteries, but the mechanism of performance improvement is still not well-understood.

TiCT/Polyurethane Constructed by Gas-Liquid Interface Self-Assembly for Underwater Sensing.

Nowadays, multifunctional, easily prepared, and highly sensitive flexible sensors have attracted extensive attention and are gradually used in various scenarios. Here, we report the design of the TiCT/polyurethane composites prepared by a facile gas-liquid interface self-assembly. The obtained flexible sensor has a wide detection range (∼900%), a low-stress detection limit (<1%), a high sensitivity (GF = 1.