A "Glue" Strategy to Engineer Cancer Cell Membrane-Camouflaged Prodrug Nanoassemblies for Efficient Targeted Chemotherapy.

Homodimeric prodrug nanoassemblies (HDPNs) offer a unique approach to improving the selectivity of chemo-drugs but demonstrate suboptimal tumor targeting efficiency. Cell membrane-camouflaged nanoparticles, particularly those using homologous cancer cell membranes (CM), can achieve excellent tumor accumulation. However, it is challenging to prepare CM-camouflaged HDPNs due to the poor affinity between hydrophobic HDPNs and hydrophilic CM.

Probing the Impact of Surface Functionalization Module on the Performance of Mitoxantrone Prodrug Nanoassemblies: Improving the Effectiveness and Safety.

Prodrug nanoassemblies are emerging as a novel drug delivery system for chemotherapy, comprising four fundamental modules: a drug module, a modification module, a response module, and a surface functionalization module. Among these modules, surface functionalization is an essential process to enhance the biocompatibility and stability of the nanoassemblies. Here, we selected mitoxantrone (MTO) as the drug module and DSPE-PEG as surface functionalization module to develop MTO prodrug nanoassemblies.

Association of Single Nucleotide Polymorphisms in the Apoptosis-Related Genes TP63 and CD40 with Risk for Lung Cancer in a Chinese Han Population.

Apoptosis plays a critical role in tumorigenesis. TP63 inhibits the pro-apoptosis function of TP53, and CD40 increases expression of anti-apoptotic proteins. Two single nucleotide polymorphisms (SNPs), rs6790167 (g243059A>G) in intron 9 of TP63 and rs1535045 (g6194C>T) in intron 1 of CD40 respectively, may affect the susceptibility of lung cancer.